LOCUS DIK1C_HUMAN 419 aa linear PRI 27-NOV-2024
DEFINITION RecName: Full=Divergent protein kinase domain 1C; AltName:
Full=Protein FAM69C.
ACCESSION Q0P6D2
VERSION Q0P6D2.3
DBSOURCE UniProtKB: locus DIK1C_HUMAN, accession Q0P6D2;
class: standard.
created: May 15, 2007.
sequence updated: May 18, 2010.
annotation updated: Nov 27, 2024.
xrefs: AC009704.8, BC019628.1, AAH19628.1, NP_001037834.2
xrefs (non-sequence databases): CCDS:CCDS42445.2,
AlphaFoldDB:Q0P6D2, BioGRID:125930, IntAct:Q0P6D2,
STRING:9606.ENSP00000344331, GlyGen:Q0P6D2, iPTMnet:Q0P6D2,
PhosphoSitePlus:Q0P6D2, BioMuta:FAM69C, DMDM:296439351,
MassIVE:Q0P6D2, PaxDb:9606-ENSP00000344331, PeptideAtlas:Q0P6D2,
ProteomicsDB:58776, ProteomicsDB:58777, Antibodypedia:62764,
DNASU:125704, Ensembl:ENST00000343998.8, Ensembl:ENSP00000344331.6,
Ensembl:ENSG00000187773.9, Ensembl:ENST00000400291.2,
Ensembl:ENSP00000383148.2, GeneID:125704, KEGG:hsa:125704,
MANE-Select:ENST00000343998.8, UCSC:uc002llk.4, AGR:HGNC:31729,
CTD:125704, DisGeNET:125704, GeneCards:DIPK1C, HGNC:31729,
HPA:ENSG00000187773, MIM 614544, neXtProt:NX_Q0P6D2,
OpenTargets:ENSG00000187773, PharmGKB:PA165428999,
VEuPathDB:HostDB:ENSG00000187773, eggNOG:ENOG502QSPC,
GeneTree:ENSGT00390000006452, HOGENOM:CLU_042490_0_0_1,
InParanoid:Q0P6D2, OMA:CGPYYAT, OrthoDB:2968643at2759,
PhylomeDB:Q0P6D2, TreeFam:TF313319, PathwayCommons:Q0P6D2,
SignaLink:Q0P6D2, BioGRID-ORCS:125704, ChiTaRS:DIPK1C,
GenomeRNAi:125704, Pharos:Q0P6D2, PRO:PR:Q0P6D2,
Proteomes:UP000005640, RNAct:Q0P6D2, Bgee:ENSG00000187773,
GO:0005789, InterPro:IPR022049, InterPro:IPR029244,
InterPro:IPR011009, PANTHER:PTHR21093:SF2, PANTHER:PTHR21093,
Pfam:PF12260, Pfam:PF14875, SMART:SM01299, SUPFAM:SSF56112
KEYWORDS Alternative splicing; Disulfide bond; Endoplasmic reticulum;
Membrane; Proteomics identification; Reference proteome;
Signal-anchor; Transmembrane; Transmembrane helix.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 419)
AUTHORS Nusbaum,C., Zody,M.C., Borowsky,M.L., Kamal,M., Kodira,C.D.,
Taylor,T.D., Whittaker,C.A., Chang,J.L., Cuomo,C.A., Dewar,K.,
FitzGerald,M.G., Yang,X., Abouelleil,A., Allen,N.R., Anderson,S.,
Bloom,T., Bugalter,B., Butler,J., Cook,A., DeCaprio,D., Engels,R.,
Garber,M., Gnirke,A., Hafez,N., Hall,J.L., Norman,C.H., Itoh,T.,
Jaffe,D.B., Kuroki,Y., Lehoczky,J., Lui,A., Macdonald,P.,
Mauceli,E., Mikkelsen,T.S., Naylor,J.W., Nicol,R., Nguyen,C.,
Noguchi,H., O'Leary,S.B., O'Neill,K., Piqani,B., Smith,C.L.,
Talamas,J.A., Topham,K., Totoki,Y., Toyoda,A., Wain,H.M.,
Young,S.K., Zeng,Q., Zimmer,A.R., Fujiyama,A., Hattori,M.,
Birren,B.W., Sakaki,Y. and Lander,E.S.
TITLE DNA sequence and analysis of human chromosome 18
JOURNAL Nature 437 (7058), 551-555 (2005)
PUBMED 16177791
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Erratum:[Nature. 2005 Dec 1;438(7068):696. O'Neill, Keith [added]]
REFERENCE 2 (residues 1 to 419)
AUTHORS Gerhard,D.S., Wagner,L., Feingold,E.A., Shenmen,C.M., Grouse,L.H.,
Schuler,G., Klein,S.L., Old,S., Rasooly,R., Good,P., Guyer,M.,
Peck,A.M., Derge,J.G., Lipman,D., Collins,F.S., Jang,W., Sherry,S.,
Feolo,M., Misquitta,L., Lee,E., Rotmistrovsky,K., Greenhut,S.F.,
Schaefer,C.F., Buetow,K., Bonner,T.I., Haussler,D., Kent,J.,
Kiekhaus,M., Furey,T., Brent,M., Prange,C., Schreiber,K.,
Shapiro,N., Bhat,N.K., Hopkins,R.F., Hsie,F., Driscoll,T.,
Soares,M.B., Casavant,T.L., Scheetz,T.E., Brown-stein,M.J.,
Usdin,T.B., Toshiyuki,S., Carninci,P., Piao,Y., Dudekula,D.B.,
Ko,M.S., Kawakami,K., Suzuki,Y., Sugano,S., Gruber,C.E.,
Smith,M.R., Simmons,B., Moore,T., Waterman,R., Johnson,S.L.,
Ruan,Y., Wei,C.L., Mathavan,S., Gunaratne,P.H., Wu,J., Garcia,A.M.,
Hulyk,S.W., Fuh,E., Yuan,Y., Sneed,A., Kowis,C., Hodgson,A.,
Muzny,D.M., McPherson,J., Gibbs,R.A., Fahey,J., Helton,E.,
Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M.,
Madari,A., Young,A.C., Wetherby,K.D., Granite,S.J., Kwong,P.N.,
Brinkley,C.P., Pearson,R.L., Bouffard,G.G., Blakesly,R.W.,
Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J.,
Myers,R.M., Butterfield,Y.S., Griffith,M., Griffith,O.L.,
Krzywinski,M.I., Liao,N., Morin,R., Palmquist,D., Petrescu,A.S.,
Skalska,U., Smailus,D.E., Stott,J.M., Schnerch,A., Schein,J.E.,
Jones,S.J., Holt,R.A., Baross,A., Marra,M.A., Clifton,S.,
Makowski,K.A., Bosak,S. and Malek,J.
CONSRTM MGC Project Team
TITLE The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC)
JOURNAL Genome Res 14 (10B), 2121-2127 (2004)
PUBMED 15489334
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).;
TISSUE=Testis
Erratum:[Genome Res. 2006 Jun;16(6):804. Morrin, Ryan [corrected to
Morin, Ryan]]
COMMENT On May 21, 2010 this sequence version replaced Q0P6D2.2.
[SUBCELLULAR LOCATION] Endoplasmic reticulum membrane
{ECO:0000250|UniProtKB:Q8BQT2}; Single-pass type II membrane
protein {ECO:0000250|UniProtKB:Q8BQT2}.
[ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named
isoforms=2; Name=1; IsoId=Q0P6D2-1; Sequence=Displayed; Name=2;
IsoId=Q0P6D2-2; Sequence=VSP_025146.
[PTM] Among the many cysteines in the lumenal domain, most are
probably involved in disulfide bonds. {ECO:0000250}.
[SIMILARITY] Belongs to the DIPK family. {ECO:0000305}.
FEATURES Location/Qualifiers
source 1..419
/organism="Homo sapiens"
/db_xref="taxon:9606"
gene 1..419
/gene="DIPK1C"
/gene_synonym="C18orf51"
/gene_synonym="FAM69C"
Protein 1..419
/product="Divergent protein kinase domain 1C"
/note="Protein FAM69C"
/UniProtKB_evidence="Evidence at protein level"
Region 1..419
/region_name="Mature chain"
/note="Divergent protein kinase domain 1C.
/id=PRO_0000286707."
Region 1..299
/region_name="Splicing variant"
/note="Missing (in isoform 2).
/evidence=ECO:0000303|PubMed:15489334. /id=VSP_025146."
Region 1..22
/region_name="Topological domain"
/note="Cytoplasmic. /evidence=ECO:0000255."
Region 16..17
/region_name="Short sequence motif of biological interest"
/note="May mediate ER retention. /evidence=ECO:0000250."
Region 23..43
/region_name="Transmembrane region"
/note="Helical. /evidence=ECO:0000255."
Region 44..419
/region_name="Topological domain"
/note="Lumenal. /evidence=ECO:0000255."
Region <51..168
/region_name="PIP49_N"
/note="N-term cysteine-rich ER, FAM69; pfam14875"
/db_xref="CDD:464353"
Region 187..385
/region_name="PIP49_C"
/note="Protein-kinase domain of FAM69; pfam12260"
/db_xref="CDD:463512"
ORIGIN
1 maraagargp agwcrrrgrc grgtllafaa wtagwvlaaa lllrahpgvl serctdeksr
61 rilaalcqdy qggtlagdlc edlcvagell fqrclhynrg kkvlqadwrg rpvvlkskee
121 afssfpplsl leeeageggq dmpeaelllm vagevksalg lelsnsslgp wwpgrrgprw
181 rgqlaslwal lqqeeyvyfs llqdlsphvl pvlgscghfy aveflaagsp hhralfpldr
241 apgapgggqa kaisdialsf ldmvnhfdsd fshrlhlcdi kpenfairsd ftvvaidvdm
301 affepkmrei leqnctgded cnffdcfsrc dlrvnkcgaq rvnnnlqvic dkifrhwfsa
361 plkssavsfq lqlqlqeavq ecadpgvpsg ntrraassvf wklrqllqat lrelqeaek
//