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RecName: Full=Divergent protein kinase domain 1C; AltName: Full=Protein FAM69C

UniProtKB/Swiss-Prot: Q0P6D2.3

Identical Proteins FASTA Graphics 

LOCUS       DIK1C_HUMAN              419 aa            linear   PRI 27-NOV-2024
DEFINITION  RecName: Full=Divergent protein kinase domain 1C; AltName:
            Full=Protein FAM69C.
ACCESSION   Q0P6D2
VERSION     Q0P6D2.3
DBSOURCE    UniProtKB: locus DIK1C_HUMAN, accession Q0P6D2;
            class: standard.
            created: May 15, 2007.
            sequence updated: May 18, 2010.
            annotation updated: Nov 27, 2024.
            xrefs: AC009704.8, BC019628.1, AAH19628.1, NP_001037834.2
            xrefs (non-sequence databases): CCDS:CCDS42445.2,
            AlphaFoldDB:Q0P6D2, BioGRID:125930, IntAct:Q0P6D2,
            STRING:9606.ENSP00000344331, GlyGen:Q0P6D2, iPTMnet:Q0P6D2,
            PhosphoSitePlus:Q0P6D2, BioMuta:FAM69C, DMDM:296439351,
            MassIVE:Q0P6D2, PaxDb:9606-ENSP00000344331, PeptideAtlas:Q0P6D2,
            ProteomicsDB:58776, ProteomicsDB:58777, Antibodypedia:62764,
            DNASU:125704, Ensembl:ENST00000343998.8, Ensembl:ENSP00000344331.6,
            Ensembl:ENSG00000187773.9, Ensembl:ENST00000400291.2,
            Ensembl:ENSP00000383148.2, GeneID:125704, KEGG:hsa:125704,
            MANE-Select:ENST00000343998.8, UCSC:uc002llk.4, AGR:HGNC:31729,
            CTD:125704, DisGeNET:125704, GeneCards:DIPK1C, HGNC:31729,
            HPA:ENSG00000187773, MIM 614544, neXtProt:NX_Q0P6D2,
            OpenTargets:ENSG00000187773, PharmGKB:PA165428999,
            VEuPathDB:HostDB:ENSG00000187773, eggNOG:ENOG502QSPC,
            GeneTree:ENSGT00390000006452, HOGENOM:CLU_042490_0_0_1,
            InParanoid:Q0P6D2, OMA:CGPYYAT, OrthoDB:2968643at2759,
            PhylomeDB:Q0P6D2, TreeFam:TF313319, PathwayCommons:Q0P6D2,
            SignaLink:Q0P6D2, BioGRID-ORCS:125704, ChiTaRS:DIPK1C,
            GenomeRNAi:125704, Pharos:Q0P6D2, PRO:PR:Q0P6D2,
            Proteomes:UP000005640, RNAct:Q0P6D2, Bgee:ENSG00000187773,
            GO:0005789, InterPro:IPR022049, InterPro:IPR029244,
            InterPro:IPR011009, PANTHER:PTHR21093:SF2, PANTHER:PTHR21093,
            Pfam:PF12260, Pfam:PF14875, SMART:SM01299, SUPFAM:SSF56112
KEYWORDS    Alternative splicing; Disulfide bond; Endoplasmic reticulum;
            Membrane; Proteomics identification; Reference proteome;
            Signal-anchor; Transmembrane; Transmembrane helix.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 419)
  AUTHORS   Nusbaum,C., Zody,M.C., Borowsky,M.L., Kamal,M., Kodira,C.D.,
            Taylor,T.D., Whittaker,C.A., Chang,J.L., Cuomo,C.A., Dewar,K.,
            FitzGerald,M.G., Yang,X., Abouelleil,A., Allen,N.R., Anderson,S.,
            Bloom,T., Bugalter,B., Butler,J., Cook,A., DeCaprio,D., Engels,R.,
            Garber,M., Gnirke,A., Hafez,N., Hall,J.L., Norman,C.H., Itoh,T.,
            Jaffe,D.B., Kuroki,Y., Lehoczky,J., Lui,A., Macdonald,P.,
            Mauceli,E., Mikkelsen,T.S., Naylor,J.W., Nicol,R., Nguyen,C.,
            Noguchi,H., O'Leary,S.B., O'Neill,K., Piqani,B., Smith,C.L.,
            Talamas,J.A., Topham,K., Totoki,Y., Toyoda,A., Wain,H.M.,
            Young,S.K., Zeng,Q., Zimmer,A.R., Fujiyama,A., Hattori,M.,
            Birren,B.W., Sakaki,Y. and Lander,E.S.
  TITLE     DNA sequence and analysis of human chromosome 18
  JOURNAL   Nature 437 (7058), 551-555 (2005)
   PUBMED   16177791
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
            Erratum:[Nature. 2005 Dec 1;438(7068):696. O'Neill, Keith [added]]
REFERENCE   2  (residues 1 to 419)
  AUTHORS   Gerhard,D.S., Wagner,L., Feingold,E.A., Shenmen,C.M., Grouse,L.H.,
            Schuler,G., Klein,S.L., Old,S., Rasooly,R., Good,P., Guyer,M.,
            Peck,A.M., Derge,J.G., Lipman,D., Collins,F.S., Jang,W., Sherry,S.,
            Feolo,M., Misquitta,L., Lee,E., Rotmistrovsky,K., Greenhut,S.F.,
            Schaefer,C.F., Buetow,K., Bonner,T.I., Haussler,D., Kent,J.,
            Kiekhaus,M., Furey,T., Brent,M., Prange,C., Schreiber,K.,
            Shapiro,N., Bhat,N.K., Hopkins,R.F., Hsie,F., Driscoll,T.,
            Soares,M.B., Casavant,T.L., Scheetz,T.E., Brown-stein,M.J.,
            Usdin,T.B., Toshiyuki,S., Carninci,P., Piao,Y., Dudekula,D.B.,
            Ko,M.S., Kawakami,K., Suzuki,Y., Sugano,S., Gruber,C.E.,
            Smith,M.R., Simmons,B., Moore,T., Waterman,R., Johnson,S.L.,
            Ruan,Y., Wei,C.L., Mathavan,S., Gunaratne,P.H., Wu,J., Garcia,A.M.,
            Hulyk,S.W., Fuh,E., Yuan,Y., Sneed,A., Kowis,C., Hodgson,A.,
            Muzny,D.M., McPherson,J., Gibbs,R.A., Fahey,J., Helton,E.,
            Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M.,
            Madari,A., Young,A.C., Wetherby,K.D., Granite,S.J., Kwong,P.N.,
            Brinkley,C.P., Pearson,R.L., Bouffard,G.G., Blakesly,R.W.,
            Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J.,
            Myers,R.M., Butterfield,Y.S., Griffith,M., Griffith,O.L.,
            Krzywinski,M.I., Liao,N., Morin,R., Palmquist,D., Petrescu,A.S.,
            Skalska,U., Smailus,D.E., Stott,J.M., Schnerch,A., Schein,J.E.,
            Jones,S.J., Holt,R.A., Baross,A., Marra,M.A., Clifton,S.,
            Makowski,K.A., Bosak,S. and Malek,J.
  CONSRTM   MGC Project Team
  TITLE     The status, quality, and expansion of the NIH full-length cDNA
            project: the Mammalian Gene Collection (MGC)
  JOURNAL   Genome Res 14 (10B), 2121-2127 (2004)
   PUBMED   15489334
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).;
            TISSUE=Testis
            Erratum:[Genome Res. 2006 Jun;16(6):804. Morrin, Ryan [corrected to
            Morin, Ryan]]
COMMENT     On May 21, 2010 this sequence version replaced Q0P6D2.2.
            [SUBCELLULAR LOCATION] Endoplasmic reticulum membrane
            {ECO:0000250|UniProtKB:Q8BQT2}; Single-pass type II membrane
            protein {ECO:0000250|UniProtKB:Q8BQT2}.
            [ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named
            isoforms=2; Name=1; IsoId=Q0P6D2-1; Sequence=Displayed; Name=2;
            IsoId=Q0P6D2-2; Sequence=VSP_025146.
            [PTM] Among the many cysteines in the lumenal domain, most are
            probably involved in disulfide bonds. {ECO:0000250}.
            [SIMILARITY] Belongs to the DIPK family. {ECO:0000305}.
FEATURES             Location/Qualifiers
     source          1..419
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
     gene            1..419
                     /gene="DIPK1C"
                     /gene_synonym="C18orf51"
                     /gene_synonym="FAM69C"
     Protein         1..419
                     /product="Divergent protein kinase domain 1C"
                     /note="Protein FAM69C"
                     /UniProtKB_evidence="Evidence at protein level"
     Region          1..419
                     /region_name="Mature chain"
                     /note="Divergent protein kinase domain 1C.
                     /id=PRO_0000286707."
     Region          1..299
                     /region_name="Splicing variant"
                     /note="Missing (in isoform 2).
                     /evidence=ECO:0000303|PubMed:15489334. /id=VSP_025146."
     Region          1..22
                     /region_name="Topological domain"
                     /note="Cytoplasmic. /evidence=ECO:0000255."
     Region          16..17
                     /region_name="Short sequence motif of biological interest"
                     /note="May mediate ER retention. /evidence=ECO:0000250."
     Region          23..43
                     /region_name="Transmembrane region"
                     /note="Helical. /evidence=ECO:0000255."
     Region          44..419
                     /region_name="Topological domain"
                     /note="Lumenal. /evidence=ECO:0000255."
     Region          <51..168
                     /region_name="PIP49_N"
                     /note="N-term cysteine-rich ER, FAM69; pfam14875"
                     /db_xref="CDD:464353"
     Region          187..385
                     /region_name="PIP49_C"
                     /note="Protein-kinase domain of FAM69; pfam12260"
                     /db_xref="CDD:463512"
ORIGIN      
        1 maraagargp agwcrrrgrc grgtllafaa wtagwvlaaa lllrahpgvl serctdeksr
       61 rilaalcqdy qggtlagdlc edlcvagell fqrclhynrg kkvlqadwrg rpvvlkskee
      121 afssfpplsl leeeageggq dmpeaelllm vagevksalg lelsnsslgp wwpgrrgprw
      181 rgqlaslwal lqqeeyvyfs llqdlsphvl pvlgscghfy aveflaagsp hhralfpldr
      241 apgapgggqa kaisdialsf ldmvnhfdsd fshrlhlcdi kpenfairsd ftvvaidvdm
      301 affepkmrei leqnctgded cnffdcfsrc dlrvnkcgaq rvnnnlqvic dkifrhwfsa
      361 plkssavsfq lqlqlqeavq ecadpgvpsg ntrraassvf wklrqllqat lrelqeaek
//
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