The PIN domain endonuclease Utp24 cleaves pre-ribosomal RNA at two coupled sites in yeast and humans.
Wells GR, Weichmann F, Colvin D, Sloan KE, Kudla G, Tollervey D, Watkins NJ, Schneider C. Nucleic Acids Res. 2016 Jun 20; 44(11):5399-409. Epub 2016 Mar 31.