RecName: Full=GMP synthase [glutamine-hydrolyzing]; AltName: Full=GMP - Protein

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Protein 3D Structure

Human GMP synthetase - glutaminase domain

PDB: 2VPI

Source: Homo sapiens

Method: X-ray Diffraction

Resolution: 2.4 Å

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Articles about the GMPS gene

Guanosine monophosphate synthase upregulation mediates cervical cancer progression by inhibiting the apoptosis of cervical cancer cells via the Stat3/P53 pathway. [Int J Oncol. 2021]
Guanosine monophosphate synthase upregulation mediates cervical cancer progression by inhibiting the apoptosis of cervical cancer cells via the Stat3/P53 pathway.
Wang J, Wu Y, Li Y, Wang Y, Shen F, Zhou J, Chen Y. Int J Oncol. 2021 Apr; 58(4). Epub 2021 Mar 2.
Nonsynonymous Polymorphism in Guanine Monophosphate Synthetase Is a Risk Factor for Unfavorable Thiopurine Metabolite Ratios in Patients With Inflammatory Bowel Disease. [Inflamm Bowel Dis. 2018]
Nonsynonymous Polymorphism in Guanine Monophosphate Synthetase Is a Risk Factor for Unfavorable Thiopurine Metabolite Ratios in Patients With Inflammatory Bowel Disease.
Roberts RL, Wallace MC, Seinen ML, van Bodegraven AA, Krishnaprasad K, Jones GT, van Rij AM, Baird A, Lawrance IC, Prosser R, et al. Inflamm Bowel Dis. 2018 Nov 29; 24(12):2606-2612.
Assignment and ordering of twenty-three unique NotI-linking clones containing expressed genes including the guanosine 5'-monophosphate synthetase gene to human chromosome 3. [Eur J Hum Genet. 1997]
Assignment and ordering of twenty-three unique NotI-linking clones containing expressed genes including the guanosine 5'-monophosphate synthetase gene to human chromosome 3.
Fedorova L, Kost-Alimova M, Gizatullin RZ, Alimov A, Zabarovska VI, Szeles A, Protopopov AI, Vorobieva NV, Kashuba VI, Klein G, et al. Eur J Hum Genet. 1997 Mar-Apr; 5(2):110-6.

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Reference sequence information

RefSeq genomic sequence
See the genomic reference sequence for the GMPS gene (NG_023247.1).
RefSeq protein isoforms
See 11 reference sequence protein isoforms for the GMPS gene.

More about the GMPS gene

In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of e...
Also Known As: GATD7

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MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF) [MODBASE, Database of Comparat...]
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RecName: Full=GMP synthase [glutamine-hydrolyzing]; AltName: Full=GMP synthetase; AltName: Full=Glutamine amidotransferase

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