RecName: Full=Sialic acid-binding Ig-like lectin 6; Short=Siglec-6; Al - Protein

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Siglec-6 mediates the uptake of extracellular vesicles through a noncanonical glycolipid binding pocket. [Nat Commun. 2023]
Siglec-6 mediates the uptake of extracellular vesicles through a noncanonical glycolipid binding pocket.
Schmidt EN, Lamprinaki D, McCord KA, Joe M, Sojitra M, Waldow A, Nguyen J, Monyror J, Kitova EN, Mozaneh F, et al. Nat Commun. 2023 Apr 22; 14(1):2327. Epub 2023 Apr 22.
Elevated trophoblastic Siglec6 contributes to the impairment of vascular endothelial cell functions by downregulating Wnt6/β-catenin signaling in preeclampsia. [Arch Biochem Biophys. 2022]
Elevated trophoblastic Siglec6 contributes to the impairment of vascular endothelial cell functions by downregulating Wnt6/β-catenin signaling in preeclampsia.
Guan X, Yu M, Wu L, Chen J, Tong J, Wu X, Yin A, Xiao T, Wang B, Zhang JV, et al. Arch Biochem Biophys. 2022 Nov 15; 730:109396. Epub 2022 Sep 14.
Expression and regulation of Siglec-6 (CD327) on human mast cells and basophils. [J Allergy Clin Immunol. 2023]
Expression and regulation of Siglec-6 (CD327) on human mast cells and basophils.
Smiljkovic D, Herrmann H, Sadovnik I, Gamperl S, Berger D, Stefanzl G, Eisenwort G, Hoermann G, Kopanja S, Dorofeeva Y, et al. J Allergy Clin Immunol. 2023 Jan; 151(1):202-211. Epub 2022 Aug 8.

RefSeq genomic sequence
See the genomic reference sequence for the SIGLEC6 gene (NG_051195.1).
RefSeq protein isoforms
See 26 reference sequence protein isoforms for the SIGLEC6 gene.

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O43699 [Domain Mapping of Disease Mut...]
O43699
Domain Mapping of Disease Mutations
Transcript/Protein Information [PANTHER Classification System]
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Reactome [Reactome]
Reactome
reagent reviews [ExactAntigen/Labome]
reagent reviews
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reagents [ExactAntigen/Labome]
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Protein