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DDB1- and CUL4-associated factor 7 [Danio rerio]

NCBI Reference Sequence: NP_956363.1

Identical Proteins FASTA Graphics 

LOCUS       NP_956363                342 aa            linear   VRT 16-SEP-2024
DEFINITION  DDB1- and CUL4-associated factor 7 [Danio rerio].
ACCESSION   NP_956363
VERSION     NP_956363.1
DBSOURCE    REFSEQ: accession NM_200069.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 342)
  AUTHORS   Bayes A, Collins MO, Reig-Viader R, Gou G, Goulding D, Izquierdo A,
            Choudhary JS, Emes RD and Grant SG.
  TITLE     Evolution of complexity in the zebrafish synapse proteome
  JOURNAL   Nat Commun 8, 14613 (2017)
   PUBMED   28252024
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 342)
  AUTHORS   Alvarado E, Yousefelahiyeh M, Alvarado G, Shang R, Whitman T,
            Martinez A, Yu Y, Pham A, Bhandari A, Wang B and Nissen RM.
  TITLE     Wdr68 Mediates Dorsal and Ventral Patterning Events for
            Craniofacial Development
  JOURNAL   PLoS One 11 (11), e0166984 (2016)
   PUBMED   27880803
  REMARK    GeneRIF: these findings reveal an indirect role for Wdr68 in the
            BMP-Edn1-Jag1b signaling hierarchy and dorso-anterior expression of
            dlx1a/2a.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 342)
  AUTHORS   Glenewinkel F, Cohen MJ, King CR, Kaspar S, Bamberg-Lemper S,
            Mymryk JS and Becker W.
  TITLE     The adaptor protein DCAF7 mediates the interaction of the
            adenovirus E1A oncoprotein with the protein kinases DYRK1A and
            HIPK2
  JOURNAL   Sci Rep 6, 28241 (2016)
   PUBMED   27307198
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 342)
  AUTHORS   Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
            Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
            Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
            GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
            Hertzano R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 342)
  AUTHORS   Wang B, Doan D, Roman Petersen Y, Alvarado E, Alvarado G, Bhandari
            A, Mohanty A, Mohanty S and Nissen RM.
  TITLE     Wdr68 requires nuclear access for craniofacial development
  JOURNAL   PLoS One 8 (1), e54363 (2013)
   PUBMED   23349862
  REMARK    GeneRIF: we show that while a GFP-Wdr68 fusion functionally
            substituted for craniofacial development in the zebrafish, that a
            Nuclear Export Signal (NES) fusion protein (GFPNESWdr68) failed to
            support craniofacial development
REFERENCE   6  (residues 1 to 342)
  AUTHORS   Leong IU, Skinner JR, Shelling AN and Love DR.
  TITLE     Identification and expression analysis of kcnh2 genes in the
            zebrafish
  JOURNAL   Biochem Biophys Res Commun 396 (4), 817-824 (2010)
   PUBMED   20438705
REFERENCE   7  (residues 1 to 342)
  AUTHORS   Mazmanian G, Kovshilovsky M, Yen D, Mohanty A, Mohanty S, Nee A and
            Nissen RM.
  TITLE     The zebrafish dyrk1b gene is important for endoderm formation
  JOURNAL   Genesis 48 (1), 20-30 (2010)
   PUBMED   20014342
REFERENCE   8  (residues 1 to 342)
  AUTHORS   Hassel D, Scholz EP, Trano N, Friedrich O, Just S, Meder B, Weiss
            DL, Zitron E, Marquart S, Vogel B, Karle CA, Seemann G, Fishman MC,
            Katus HA and Rottbauer W.
  TITLE     Deficient zebrafish ether-a-go-go-related gene channel gating
            causes short-QT syndrome in zebrafish reggae mutants
  JOURNAL   Circulation 117 (7), 866-875 (2008)
   PUBMED   18250272
REFERENCE   9  (residues 1 to 342)
  AUTHORS   Nissen RM, Amsterdam A and Hopkins N.
  TITLE     A zebrafish screen for craniofacial mutants identifies wdr68 as a
            highly conserved gene required for endothelin-1 expression
  JOURNAL   BMC Dev Biol 6, 28 (2006)
   PUBMED   16759393
  REMARK    GeneRIF: The initial characterization of wdr68 suggests an
            important role in craniofacial development for the highly conserved
            Wdr68-Dyrk1 protein complexes.
            Publication Status: Online-Only
REFERENCE   10 (residues 1 to 342)
  AUTHORS   Amsterdam A, Nissen RM, Sun Z, Swindell EC, Farrington S and
            Hopkins N.
  TITLE     Identification of 315 genes essential for early zebrafish
            development
  JOURNAL   Proc Natl Acad Sci U S A 101 (35), 12792-12797 (2004)
   PUBMED   15256591
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC053157.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053157.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505371
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..342
                     /organism="Danio rerio"
                     /db_xref="taxon:7955"
                     /chromosome="3"
                     /map="3"
     Protein         1..342
                     /product="DDB1- and CUL4-associated factor 7"
                     /note="WD repeat domain 68; AN11 homolog; dirty south;
                     dys"
                     /calculated_mol_wt=38803
     Region          <19..330
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          19..66
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          72..113
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          118..170
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          178..217
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          224..263
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          269..309
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..342
                     /gene="dcaf7"
                     /gene_synonym="fj83g06; han11l; wdr68; wu:fj83g06;
                     zgc:63940"
                     /coded_by="NM_200069.1:145..1173"
                     /db_xref="GeneID:337565"
                     /db_xref="ZFIN:ZDB-GENE-030131-9511"
ORIGIN      
        1 mslhgkrkei ykyeapwtvy amnwsvrpdk rfrlalgsfv eeynnkvqlv gleeessefv
       61 crntfdhpyp ttkimwipdt kgvypdllat sgdylriwrv ndtetrlecl lnnnknsdfc
      121 apltsfdwne vdpnllgtss idttctiwgl etgqvlgrvn lvsghvktql iahdkevydi
      181 afsragggrd mfasvgadgs vrmfdlrhle hstiiyedpq hhpllrlcwn kqdpnylatm
      241 amdgmevvil dvrvpctpva rlnnhracvn giawaphssc hictaaddhq aliwdiqqmp
      301 raiedpilay taegeinnvq wastqpdwia icynncleil rv
//
Feature
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