LOCUS NP_956363 342 aa linear VRT 16-SEP-2024
DEFINITION DDB1- and CUL4-associated factor 7 [Danio rerio].
ACCESSION NP_956363
VERSION NP_956363.1
DBSOURCE REFSEQ: accession NM_200069.1
KEYWORDS RefSeq.
SOURCE Danio rerio (zebrafish)
ORGANISM Danio rerio
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE 1 (residues 1 to 342)
AUTHORS Bayes A, Collins MO, Reig-Viader R, Gou G, Goulding D, Izquierdo A,
Choudhary JS, Emes RD and Grant SG.
TITLE Evolution of complexity in the zebrafish synapse proteome
JOURNAL Nat Commun 8, 14613 (2017)
PUBMED 28252024
REMARK Publication Status: Online-Only
REFERENCE 2 (residues 1 to 342)
AUTHORS Alvarado E, Yousefelahiyeh M, Alvarado G, Shang R, Whitman T,
Martinez A, Yu Y, Pham A, Bhandari A, Wang B and Nissen RM.
TITLE Wdr68 Mediates Dorsal and Ventral Patterning Events for
Craniofacial Development
JOURNAL PLoS One 11 (11), e0166984 (2016)
PUBMED 27880803
REMARK GeneRIF: these findings reveal an indirect role for Wdr68 in the
BMP-Edn1-Jag1b signaling hierarchy and dorso-anterior expression of
dlx1a/2a.
Publication Status: Online-Only
REFERENCE 3 (residues 1 to 342)
AUTHORS Glenewinkel F, Cohen MJ, King CR, Kaspar S, Bamberg-Lemper S,
Mymryk JS and Becker W.
TITLE The adaptor protein DCAF7 mediates the interaction of the
adenovirus E1A oncoprotein with the protein kinases DYRK1A and
HIPK2
JOURNAL Sci Rep 6, 28241 (2016)
PUBMED 27307198
REMARK Publication Status: Online-Only
REFERENCE 4 (residues 1 to 342)
AUTHORS Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
Hertzano R.
TITLE RFX transcription factors are essential for hearing in mice
JOURNAL Nat Commun 6, 8549 (2015)
PUBMED 26469318
REMARK Publication Status: Online-Only
REFERENCE 5 (residues 1 to 342)
AUTHORS Wang B, Doan D, Roman Petersen Y, Alvarado E, Alvarado G, Bhandari
A, Mohanty A, Mohanty S and Nissen RM.
TITLE Wdr68 requires nuclear access for craniofacial development
JOURNAL PLoS One 8 (1), e54363 (2013)
PUBMED 23349862
REMARK GeneRIF: we show that while a GFP-Wdr68 fusion functionally
substituted for craniofacial development in the zebrafish, that a
Nuclear Export Signal (NES) fusion protein (GFPNESWdr68) failed to
support craniofacial development
REFERENCE 6 (residues 1 to 342)
AUTHORS Leong IU, Skinner JR, Shelling AN and Love DR.
TITLE Identification and expression analysis of kcnh2 genes in the
zebrafish
JOURNAL Biochem Biophys Res Commun 396 (4), 817-824 (2010)
PUBMED 20438705
REFERENCE 7 (residues 1 to 342)
AUTHORS Mazmanian G, Kovshilovsky M, Yen D, Mohanty A, Mohanty S, Nee A and
Nissen RM.
TITLE The zebrafish dyrk1b gene is important for endoderm formation
JOURNAL Genesis 48 (1), 20-30 (2010)
PUBMED 20014342
REFERENCE 8 (residues 1 to 342)
AUTHORS Hassel D, Scholz EP, Trano N, Friedrich O, Just S, Meder B, Weiss
DL, Zitron E, Marquart S, Vogel B, Karle CA, Seemann G, Fishman MC,
Katus HA and Rottbauer W.
TITLE Deficient zebrafish ether-a-go-go-related gene channel gating
causes short-QT syndrome in zebrafish reggae mutants
JOURNAL Circulation 117 (7), 866-875 (2008)
PUBMED 18250272
REFERENCE 9 (residues 1 to 342)
AUTHORS Nissen RM, Amsterdam A and Hopkins N.
TITLE A zebrafish screen for craniofacial mutants identifies wdr68 as a
highly conserved gene required for endothelin-1 expression
JOURNAL BMC Dev Biol 6, 28 (2006)
PUBMED 16759393
REMARK GeneRIF: The initial characterization of wdr68 suggests an
important role in craniofacial development for the highly conserved
Wdr68-Dyrk1 protein complexes.
Publication Status: Online-Only
REFERENCE 10 (residues 1 to 342)
AUTHORS Amsterdam A, Nissen RM, Sun Z, Swindell EC, Farrington S and
Hopkins N.
TITLE Identification of 315 genes essential for early zebrafish
development
JOURNAL Proc Natl Acad Sci U S A 101 (35), 12792-12797 (2004)
PUBMED 15256591
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from BC053157.1.
##Evidence-Data-START##
Transcript exon combination :: BC053157.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA3505370, SAMEA3505371
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..342
/organism="Danio rerio"
/db_xref="taxon:7955"
/chromosome="3"
/map="3"
Protein 1..342
/product="DDB1- and CUL4-associated factor 7"
/note="WD repeat domain 68; AN11 homolog; dirty south;
dys"
/calculated_mol_wt=38803
Region <19..330
/region_name="WD40"
/note="WD40 repeat [General function prediction only];
COG2319"
/db_xref="CDD:441893"
Region 19..66
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 72..113
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 118..170
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 178..217
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 224..263
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 269..309
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
CDS 1..342
/gene="dcaf7"
/gene_synonym="fj83g06; han11l; wdr68; wu:fj83g06;
zgc:63940"
/coded_by="NM_200069.1:145..1173"
/db_xref="GeneID:337565"
/db_xref="ZFIN:ZDB-GENE-030131-9511"
ORIGIN
1 mslhgkrkei ykyeapwtvy amnwsvrpdk rfrlalgsfv eeynnkvqlv gleeessefv
61 crntfdhpyp ttkimwipdt kgvypdllat sgdylriwrv ndtetrlecl lnnnknsdfc
121 apltsfdwne vdpnllgtss idttctiwgl etgqvlgrvn lvsghvktql iahdkevydi
181 afsragggrd mfasvgadgs vrmfdlrhle hstiiyedpq hhpllrlcwn kqdpnylatm
241 amdgmevvil dvrvpctpva rlnnhracvn giawaphssc hictaaddhq aliwdiqqmp
301 raiedpilay taegeinnvq wastqpdwia icynncleil rv
//