The large isoform of Drosophila melanogaster heterochromatin protein 2 plays a critical role in gene silencing and chromosome structure.
Shaffer CD, Cenci G, Thompson B, Stephens GE, Slawson EE, Adu-Wusu K, Gatti M, Elgin SC. Genetics. 2006 Nov; 174(3):1189-204. Epub 2006 Sep 15.