LOCUS NP_198313 765 aa linear PLN 20-OCT-2022
DEFINITION Voltage-gated chloride channel family protein [Arabidopsis
thaliana].
ACCESSION NP_198313
VERSION NP_198313.2
DBLINK BioProject: PRJNA116
BioSample: SAMN03081427
DBSOURCE REFSEQ: accession NM_122852.4
KEYWORDS RefSeq.
SOURCE Arabidopsis thaliana (thale cress)
ORGANISM Arabidopsis thaliana
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae;
Camelineae; Arabidopsis.
REFERENCE 1 (residues 1 to 765)
AUTHORS Tabata,S., Kaneko,T., Nakamura,Y., Kotani,H., Kato,T., Asamizu,E.,
Miyajima,N., Sasamoto,S., Kimura,T., Hosouchi,T., Kawashima,K.,
Kohara,M., Matsumoto,M., Matsuno,A., Muraki,A., Nakayama,S.,
Nakazaki,N., Naruo,K., Okumura,S., Shinpo,S., Takeuchi,C., Wada,T.,
Watanabe,A., Yamada,M., Yasuda,M., Sato,S., de la Bastide,M.,
Huang,E., Spiegel,L., Gnoj,L., O'Shaughnessy,A., Preston,R.,
Habermann,K., Murray,J., Johnson,D., Rohlfing,T., Nelson,J.,
Stoneking,T., Pepin,K., Spieth,J., Sekhon,M., Armstrong,J.,
Becker,M., Belter,E., Cordum,H., Cordes,M., Courtney,L.,
Courtney,W., Dante,M., Du,H., Edwards,J., Fryman,J., Haakensen,B.,
Lamar,E., Latreille,P., Leonard,S., Meyer,R., Mulvaney,E.,
Ozersky,P., Riley,A., Strowmatt,C., Wagner-McPherson,C., Wollam,A.,
Yoakum,M., Bell,M., Dedhia,N., Parnell,L., Shah,R., Rodriguez,M.,
See,L.H., Vil,D., Baker,J., Kirchoff,K., Toth,K., King,L.,
Bahret,A., Miller,B., Marra,M., Martienssen,R., McCombie,W.R.,
Wilson,R.K., Murphy,G., Bancroft,I., Volckaert,G., Wambutt,R.,
Dusterhoft,A., Stiekema,W., Pohl,T., Entian,K.D., Terryn,N.,
Hartley,N., Bent,E., Johnson,S., Langham,S.A., McCullagh,B.,
Robben,J., Grymonprez,B., Zimmermann,W., Ramsperger,U., Wedler,H.,
Balke,K., Wedler,E., Peters,S., van Staveren,M., Dirkse,W.,
Mooijman,P., Lankhorst,R.K., Weitzenegger,T., Bothe,G., Rose,M.,
Hauf,J., Berneiser,S., Hempel,S., Feldpausch,M., Lamberth,S.,
Villarroel,R., Gielen,J., Ardiles,W., Bents,O., Lemcke,K.,
Kolesov,G., Mayer,K., Rudd,S., Schoof,H., Schueller,C.,
Zaccaria,P., Mewes,H.W., Bevan,M. and Fransz,P.
CONSRTM Kazusa DNA Research Institute; Cold Spring Harbor and Washington
University in St Louis Sequencing Consortium; European Union
Arabidopsis Genome Sequencing Consortium
TITLE Sequence and analysis of chromosome 5 of the plant Arabidopsis
thaliana
JOURNAL Nature 408 (6814), 823-826 (2000)
PUBMED 11130714
REFERENCE 2 (residues 1 to 765)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (19-OCT-2022) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 3 (residues 1 to 765)
AUTHORS Krishnakumar,V., Cheng,C.-Y., Chan,A.P., Schobel,S., Kim,M.,
Ferlanti,E.S., Belyaeva,I., Rosen,B.D., Micklem,G., Miller,J.R.,
Vaughn,M. and Town,C.D.
TITLE Direct Submission
JOURNAL Submitted (17-MAY-2016) Plant Genomics, J. Craig Venter Institute,
9704 Medical Center Dr, Rockville, MD 20850, USA
REMARK Protein update by submitter
REFERENCE 4 (residues 1 to 765)
AUTHORS Swarbreck,D., Lamesch,P., Wilks,C. and Huala,E.
CONSRTM TAIR
TITLE Direct Submission
JOURNAL Submitted (18-FEB-2011) Department of Plant Biology, Carnegie
Institution, 260 Panama Street, Stanford, CA, USA
COMMENT REVIEWED REFSEQ: This record has been curated by TAIR and Araport.
The reference sequence is identical to AED93891.
On May 26, 2011 this sequence version replaced NP_198313.1.
Method: conceptual translation.
FEATURES Location/Qualifiers
source 1..765
/organism="Arabidopsis thaliana"
/db_xref="taxon:3702"
/chromosome="5"
/ecotype="Columbia"
Protein 1..765
/product="Voltage-gated chloride channel family protein"
/calculated_mol_wt=83727
Region 39..561
/region_name="Voltage_gated_ClC"
/note="CLC voltage-gated chloride channel. The ClC
chloride channels catalyse the selective flow of Cl- ions
across cell membranes, thereby regulating electrical
excitation in skeletal muscle and the flow of salt and
water across epithelial barriers. This...; cl02915"
/db_xref="CDD:445960"
Site order(143..147,185..189,462..466)
/site_type="active"
/note="Cl- selectivity filter [active]"
/db_xref="CDD:238233"
Site order(144,146,187..188,462..464)
/site_type="other"
/note="Cl- binding residues [ion binding]"
/db_xref="CDD:238233"
Site 187
/site_type="active"
/note="pore gating glutamate residue [active]"
/db_xref="CDD:238233"
Site order(245,254,265,272,507,510,518,530,537..538)
/site_type="other"
/note="dimer interface [polypeptide binding]"
/db_xref="CDD:238233"
Region 563..740
/region_name="CBS_pair_voltage-gated_CLC_euk_bac"
/note="Two tandem repeats of the cystathionine
beta-synthase (CBS pair) domains associated with the
voltage gated CLC (chloride channel) in eukaryotes and
bacteria; cd04591"
/db_xref="CDD:341367"
Site order(569,580..582,604..606,715,731,733,735..736,739)
/site_type="other"
/note="ligand binding site II [chemical binding]"
/db_xref="CDD:341367"
Region 569..687
/region_name="CBS repeat"
/note="CBS repeat [structural motif]"
/db_xref="CDD:341367"
Site order(604,622,626..627,630,693,715..717,735)
/site_type="other"
/note="putative ligand binding site I [chemical binding]"
/db_xref="CDD:341367"
Region 693..739
/region_name="CBS repeat"
/note="CBS repeat [structural motif]"
/db_xref="CDD:341367"
CDS 1..765
/locus_tag="AT5G33280"
/gene_synonym="AtCLCg; chloride channel G; CLCg; F19N2.1"
/coded_by="NM_122852.4:138..2435"
/inference="Similar to RNA sequence,
EST:INSD:EH896888.1,INSD:ES083065.1,INSD:EL229893.1,
INSD:EH891737.1,INSD:EH914773.1,INSD:AV560768.1,
INSD:ES098989.1,INSD:ES095761.1"
/note="Voltage-gated chloride channel family protein;
FUNCTIONS IN: protein binding, anion channel activity,
voltage-gated chloride channel activity; INVOLVED IN:
chloride transport, transmembrane transport; LOCATED IN:
intracellular, membrane; EXPRESSED IN: 22 plant
structures; EXPRESSED DURING: 13 growth stages; CONTAINS
InterPro DOMAIN/s: Chloride channel, core
(InterPro:IPR014743), Chloride channel, voltage gated
(InterPro:IPR001807), Chloride channel ClC-plant
(InterPro:IPR002251), Cystathionine beta-synthase, core
(InterPro:IPR000644); BEST Arabidopsis thaliana protein
match is: chloride channel C (TAIR:AT5G49890.1); Has 6777
Blast hits to 6308 proteins in 1692 species: Archae - 118;
Bacteria - 4354; Metazoa - 967; Fungi - 343; Plants - 345;
Viruses - 0; Other Eukaryotes - 650 (source: NCBI BLink)."
/db_xref="GeneID:833300"
/db_xref="TAIR:AT5G33280"
/db_xref="Araport:AT5G33280"
ORIGIN
1 mpnsttedsv avpllpslrr atnstsqvai vganvcpies ldyeiaendf fkqdwrgrsk
61 veifqyvfmk wllcfcigii vsligfannl avenlagvkf vvtsnmmiag rfamgfvvfs
121 vtnliltlfa svitafvapa aagsgipevk aylngvdape ifslrtliik iignisavsa
181 slligkagpm vhtgacvasi lgqggskryr ltwrwlrffk ndrdrrdlvt cgaaagiaas
241 frapvggvlf aleemsswwr sallwriffs tavvaivlra lidvclsgkc glfgkgglim
301 fdvysenasy hlgdvlpvll lgvvggilgs lynflldkvl raynyiyekg vtwkillaca
361 isiftscllf glpflascqp cpvdaleecp tigrsgnfkk yqcppghynd laslifntnd
421 daiknlfskn tdfefhyfsv lvffvtcffl sifsygivap aglfvpvivt gasygrfvgm
481 llgsnsnlnh glfavlgaas flggtmrmtv stcvillelt nnllllpmmm vvllisktva
541 dgfnaniynl imklkgfpyl yshaepymrq llvgdvvtgp lqvfngiekv etivhvlktt
601 nhngfpvvdg pplaaapvlh glilrahilt llkkrvfmps pvacdsntls qfkaeefakk
661 gsgrsdkied velseeelnm yldlhpfsna spytvvetms lakalilfre vgirhllvip
721 ktsnrppvvg iltrhdfmpe hilglhpsvs rskwkrlrir lpffs
//