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Voltage-gated chloride channel family protein [Arabidopsis thaliana]

NCBI Reference Sequence: NP_198313.2

Identical Proteins FASTA Graphics 

LOCUS       NP_198313                765 aa            linear   PLN 20-OCT-2022
DEFINITION  Voltage-gated chloride channel family protein [Arabidopsis
            thaliana].
ACCESSION   NP_198313
VERSION     NP_198313.2
DBLINK      BioProject: PRJNA116
            BioSample: SAMN03081427
DBSOURCE    REFSEQ: accession NM_122852.4
KEYWORDS    RefSeq.
SOURCE      Arabidopsis thaliana (thale cress)
  ORGANISM  Arabidopsis thaliana
            Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
            Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae;
            Pentapetalae; rosids; malvids; Brassicales; Brassicaceae;
            Camelineae; Arabidopsis.
REFERENCE   1  (residues 1 to 765)
  AUTHORS   Tabata,S., Kaneko,T., Nakamura,Y., Kotani,H., Kato,T., Asamizu,E.,
            Miyajima,N., Sasamoto,S., Kimura,T., Hosouchi,T., Kawashima,K.,
            Kohara,M., Matsumoto,M., Matsuno,A., Muraki,A., Nakayama,S.,
            Nakazaki,N., Naruo,K., Okumura,S., Shinpo,S., Takeuchi,C., Wada,T.,
            Watanabe,A., Yamada,M., Yasuda,M., Sato,S., de la Bastide,M.,
            Huang,E., Spiegel,L., Gnoj,L., O'Shaughnessy,A., Preston,R.,
            Habermann,K., Murray,J., Johnson,D., Rohlfing,T., Nelson,J.,
            Stoneking,T., Pepin,K., Spieth,J., Sekhon,M., Armstrong,J.,
            Becker,M., Belter,E., Cordum,H., Cordes,M., Courtney,L.,
            Courtney,W., Dante,M., Du,H., Edwards,J., Fryman,J., Haakensen,B.,
            Lamar,E., Latreille,P., Leonard,S., Meyer,R., Mulvaney,E.,
            Ozersky,P., Riley,A., Strowmatt,C., Wagner-McPherson,C., Wollam,A.,
            Yoakum,M., Bell,M., Dedhia,N., Parnell,L., Shah,R., Rodriguez,M.,
            See,L.H., Vil,D., Baker,J., Kirchoff,K., Toth,K., King,L.,
            Bahret,A., Miller,B., Marra,M., Martienssen,R., McCombie,W.R.,
            Wilson,R.K., Murphy,G., Bancroft,I., Volckaert,G., Wambutt,R.,
            Dusterhoft,A., Stiekema,W., Pohl,T., Entian,K.D., Terryn,N.,
            Hartley,N., Bent,E., Johnson,S., Langham,S.A., McCullagh,B.,
            Robben,J., Grymonprez,B., Zimmermann,W., Ramsperger,U., Wedler,H.,
            Balke,K., Wedler,E., Peters,S., van Staveren,M., Dirkse,W.,
            Mooijman,P., Lankhorst,R.K., Weitzenegger,T., Bothe,G., Rose,M.,
            Hauf,J., Berneiser,S., Hempel,S., Feldpausch,M., Lamberth,S.,
            Villarroel,R., Gielen,J., Ardiles,W., Bents,O., Lemcke,K.,
            Kolesov,G., Mayer,K., Rudd,S., Schoof,H., Schueller,C.,
            Zaccaria,P., Mewes,H.W., Bevan,M. and Fransz,P.
  CONSRTM   Kazusa DNA Research Institute; Cold Spring Harbor and Washington
            University in St Louis Sequencing Consortium; European Union
            Arabidopsis Genome Sequencing Consortium
  TITLE     Sequence and analysis of chromosome 5 of the plant Arabidopsis
            thaliana
  JOURNAL   Nature 408 (6814), 823-826 (2000)
   PUBMED   11130714
REFERENCE   2  (residues 1 to 765)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (residues 1 to 765)
  AUTHORS   Krishnakumar,V., Cheng,C.-Y., Chan,A.P., Schobel,S., Kim,M.,
            Ferlanti,E.S., Belyaeva,I., Rosen,B.D., Micklem,G., Miller,J.R.,
            Vaughn,M. and Town,C.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-MAY-2016) Plant Genomics, J. Craig Venter Institute,
            9704 Medical Center Dr, Rockville, MD 20850, USA
  REMARK    Protein update by submitter
REFERENCE   4  (residues 1 to 765)
  AUTHORS   Swarbreck,D., Lamesch,P., Wilks,C. and Huala,E.
  CONSRTM   TAIR
  TITLE     Direct Submission
  JOURNAL   Submitted (18-FEB-2011) Department of Plant Biology, Carnegie
            Institution, 260 Panama Street, Stanford, CA, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by TAIR and Araport.
            The reference sequence is identical to AED93891.
            
            On May 26, 2011 this sequence version replaced NP_198313.1.
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..765
                     /organism="Arabidopsis thaliana"
                     /db_xref="taxon:3702"
                     /chromosome="5"
                     /ecotype="Columbia"
     Protein         1..765
                     /product="Voltage-gated chloride channel family protein"
                     /calculated_mol_wt=83727
     Region          39..561
                     /region_name="Voltage_gated_ClC"
                     /note="CLC voltage-gated chloride channel. The ClC
                     chloride channels catalyse the selective flow of Cl- ions
                     across cell membranes, thereby regulating electrical
                     excitation in skeletal muscle and the flow of salt and
                     water across epithelial barriers. This...; cl02915"
                     /db_xref="CDD:445960"
     Site            order(143..147,185..189,462..466)
                     /site_type="active"
                     /note="Cl- selectivity filter [active]"
                     /db_xref="CDD:238233"
     Site            order(144,146,187..188,462..464)
                     /site_type="other"
                     /note="Cl- binding residues [ion binding]"
                     /db_xref="CDD:238233"
     Site            187
                     /site_type="active"
                     /note="pore gating glutamate residue [active]"
                     /db_xref="CDD:238233"
     Site            order(245,254,265,272,507,510,518,530,537..538)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:238233"
     Region          563..740
                     /region_name="CBS_pair_voltage-gated_CLC_euk_bac"
                     /note="Two tandem repeats of the cystathionine
                     beta-synthase (CBS pair) domains associated with the
                     voltage gated CLC (chloride channel) in eukaryotes and
                     bacteria; cd04591"
                     /db_xref="CDD:341367"
     Site            order(569,580..582,604..606,715,731,733,735..736,739)
                     /site_type="other"
                     /note="ligand binding site II [chemical binding]"
                     /db_xref="CDD:341367"
     Region          569..687
                     /region_name="CBS repeat"
                     /note="CBS repeat [structural motif]"
                     /db_xref="CDD:341367"
     Site            order(604,622,626..627,630,693,715..717,735)
                     /site_type="other"
                     /note="putative ligand binding site I [chemical binding]"
                     /db_xref="CDD:341367"
     Region          693..739
                     /region_name="CBS repeat"
                     /note="CBS repeat [structural motif]"
                     /db_xref="CDD:341367"
     CDS             1..765
                     /locus_tag="AT5G33280"
                     /gene_synonym="AtCLCg; chloride channel G; CLCg; F19N2.1"
                     /coded_by="NM_122852.4:138..2435"
                     /inference="Similar to RNA sequence,
                     EST:INSD:EH896888.1,INSD:ES083065.1,INSD:EL229893.1,
                     INSD:EH891737.1,INSD:EH914773.1,INSD:AV560768.1,
                     INSD:ES098989.1,INSD:ES095761.1"
                     /note="Voltage-gated chloride channel family protein;
                     FUNCTIONS IN: protein binding, anion channel activity,
                     voltage-gated chloride channel activity; INVOLVED IN:
                     chloride transport, transmembrane transport; LOCATED IN:
                     intracellular, membrane; EXPRESSED IN: 22 plant
                     structures; EXPRESSED DURING: 13 growth stages; CONTAINS
                     InterPro DOMAIN/s: Chloride channel, core
                     (InterPro:IPR014743), Chloride channel, voltage gated
                     (InterPro:IPR001807), Chloride channel ClC-plant
                     (InterPro:IPR002251), Cystathionine beta-synthase, core
                     (InterPro:IPR000644); BEST Arabidopsis thaliana protein
                     match is: chloride channel C (TAIR:AT5G49890.1); Has 6777
                     Blast hits to 6308 proteins in 1692 species: Archae - 118;
                     Bacteria - 4354; Metazoa - 967; Fungi - 343; Plants - 345;
                     Viruses - 0; Other Eukaryotes - 650 (source: NCBI BLink)."
                     /db_xref="GeneID:833300"
                     /db_xref="TAIR:AT5G33280"
                     /db_xref="Araport:AT5G33280"
ORIGIN      
        1 mpnsttedsv avpllpslrr atnstsqvai vganvcpies ldyeiaendf fkqdwrgrsk
       61 veifqyvfmk wllcfcigii vsligfannl avenlagvkf vvtsnmmiag rfamgfvvfs
      121 vtnliltlfa svitafvapa aagsgipevk aylngvdape ifslrtliik iignisavsa
      181 slligkagpm vhtgacvasi lgqggskryr ltwrwlrffk ndrdrrdlvt cgaaagiaas
      241 frapvggvlf aleemsswwr sallwriffs tavvaivlra lidvclsgkc glfgkgglim
      301 fdvysenasy hlgdvlpvll lgvvggilgs lynflldkvl raynyiyekg vtwkillaca
      361 isiftscllf glpflascqp cpvdaleecp tigrsgnfkk yqcppghynd laslifntnd
      421 daiknlfskn tdfefhyfsv lvffvtcffl sifsygivap aglfvpvivt gasygrfvgm
      481 llgsnsnlnh glfavlgaas flggtmrmtv stcvillelt nnllllpmmm vvllisktva
      541 dgfnaniynl imklkgfpyl yshaepymrq llvgdvvtgp lqvfngiekv etivhvlktt
      601 nhngfpvvdg pplaaapvlh glilrahilt llkkrvfmps pvacdsntls qfkaeefakk
      661 gsgrsdkied velseeelnm yldlhpfsna spytvvetms lakalilfre vgirhllvip
      721 ktsnrppvvg iltrhdfmpe hilglhpsvs rskwkrlrir lpffs
//
Feature
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Protein clusters for NP_198313.2

  • Cl-channel clc-7
    Total proteins: 68
    Total genera: 0
    Conserved in: Viridiplantae

Reference sequence information

  • RefSeq mRNA
    See reference mRNA sequence for the AT5G33280 gene (NM_122852.4).

More about the AT5G33280 gene

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