LOCUS NP_149028 109 aa linear ROD 10-DEC-2024
DEFINITION oncomodulin [Mus musculus].
ACCESSION NP_149028 XP_001001609
VERSION NP_149028.2
DBSOURCE REFSEQ: accession NM_033039.3
KEYWORDS RefSeq; RefSeq Select.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (residues 1 to 109)
AUTHORS Lachgar-Ruiz,M., Ingham,N.J., Martelletti,E., Chen,J., James,E.,
Panganiban,C., Lewis,M.A. and Steel,K.P.
TITLE Two new mouse alleles of Ocm and Slc26a5
JOURNAL Hear Res 452, 109109 (2024)
PUBMED 39241555
REFERENCE 2 (residues 1 to 109)
AUTHORS Goodrich,E.J. and Deans,M.R.
TITLE Emx2 lineage tracing reveals antecedent patterns of planar polarity
in the mouse inner ear
JOURNAL Development 151 (10) (2024)
PUBMED 38682291
REFERENCE 3 (residues 1 to 109)
AUTHORS Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
Jackson,S.P. and Balmus,G.
CONSRTM Sanger Mouse Genetics Project
TITLE Genetic determinants of micronucleus formation in vivo
JOURNAL Nature 627 (8002), 130-136 (2024)
PUBMED 38355793
REFERENCE 4 (residues 1 to 109)
AUTHORS Yang,Y., Murtha,K., Climer,L.K., Ceriani,F., Thompson,P.,
Hornak,A.J., Marcotti,W. and Simmons,D.D.
TITLE Oncomodulin regulates spontaneous calcium signalling and maturation
of afferent innervation in cochlear outer hair cells
JOURNAL J Physiol 601 (19), 4291-4308 (2023)
PUBMED 37642186
REMARK GeneRIF: Oncomodulin regulates spontaneous calcium signalling and
maturation of afferent innervation in cochlear outer hair cells.
REFERENCE 5 (residues 1 to 109)
AUTHORS Kwon,M.J., Seo,Y., Cho,H., Kim,H.S., Oh,Y.J., Geniscan,S., Kim,M.,
Park,H.H., Joe,E.H., Kwon,M.H., Kang,H.C. and Kim,B.G.
TITLE Nanogel-mediated delivery of oncomodulin secreted from
regeneration-associated macrophages promotes sensory axon
regeneration in the spinal cord
JOURNAL Theranostics 12 (13), 5856-5876 (2022)
PUBMED 35966584
REMARK Publication Status: Online-Only
REFERENCE 6 (residues 1 to 109)
AUTHORS Hsiao,C.D., Tsai,W.Y. and Tsai,H.J.
TITLE Isolation and expression of two zebrafish homologues of parvalbumin
genes related to chicken CPV3 and mammalian oncomodulin
JOURNAL Mech Dev 119 Suppl 1, S161-S166 (2002)
PUBMED 14516679
REFERENCE 7 (residues 1 to 109)
AUTHORS Staubli,F., Klein,A., Rentsch,J.M., Hameister,H. and Berchtold,M.W.
TITLE Structure and chromosomal localization of the mouse oncomodulin
gene
JOURNAL Mamm Genome 6 (11), 769-777 (1995)
PUBMED 8597631
REFERENCE 8 (residues 1 to 109)
AUTHORS Ritzler,J.M., Sawhney,R., Geurts van Kessel,A.H., Grzeschik,K.H.,
Schinzel,A. and Berchtold,M.W.
TITLE The genes for the highly homologous Ca(2+)-binding proteins
oncomodulin and parvalbumin are not linked in the human genome
JOURNAL Genomics 12 (3), 567-572 (1992)
PUBMED 1559707
REFERENCE 9 (residues 1 to 109)
AUTHORS Banville,D., Rotaru,M. and Boie,Y.
TITLE The intracisternal A particle derived solo LTR promoter of the rat
oncomodulin gene is not present in the mouse gene
JOURNAL Genetica 86 (1-3), 85-97 (1992)
PUBMED 1468649
REFERENCE 10 (residues 1 to 109)
AUTHORS Banville,D. and Boie,Y.
TITLE Retroviral long terminal repeat is the promoter of the gene
encoding the tumor-associated calcium-binding protein oncomodulin
in the rat
JOURNAL J Mol Biol 207 (3), 481-490 (1989)
PUBMED 2474657
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC121917.2.
On Apr 14, 2007 this sequence version replaced NP_149028.1.
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: EL956645.1, ERR3363658.3031409.1
[ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN00849377, SAMN00849380
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..109
/organism="Mus musculus"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="5"
/map="5 82.85 cM"
Protein 1..109
/product="oncomodulin"
/note="OM; parvalbumin beta"
/calculated_mol_wt=12129
Site 2
/site_type="acetylation"
/note="N-acetylserine.
/evidence=ECO:0000250|UniProtKB:P02631; propagated from
UniProtKB/Swiss-Prot (P51879.2)"
Region 9..109
/region_name="EFh_parvalbumin_beta"
/note="EF-hand, calcium binding motif, found in
beta-parvalbumin; cd16255"
/db_xref="CDD:319998"
Region 9..38
/region_name="EF-hand motif"
/note="EF-hand motif [structural motif]"
/db_xref="CDD:319998"
Region 43..72
/region_name="EF-hand motif"
/note="EF-hand motif [structural motif]"
/db_xref="CDD:319998"
Site order(52,54,56,60,63,91,93,95,102)
/site_type="other"
/note="Ca binding site [ion binding]"
/db_xref="CDD:319998"
Region 82..109
/region_name="EF-hand motif"
/note="EF-hand motif [structural motif]"
/db_xref="CDD:319998"
Region 82..109
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (P51879.2)"
CDS 1..109
/gene="Ocm"
/coded_by="NM_033039.3:137..466"
/db_xref="CCDS:CCDS51693.1"
/db_xref="GeneID:18261"
/db_xref="MGI:MGI:97401"
ORIGIN
1 msitdilsad diaaalqecq dpdtfepqkf fqtsglskms asqlkdifqf idndqsgyld
61 edelkyflqr fqsdarelte setkslmdaa dndgdgkiga defqemvhs
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