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oncomodulin [Mus musculus]

NCBI Reference Sequence: NP_149028.2

Identical Proteins FASTA Graphics 

LOCUS       NP_149028                109 aa            linear   ROD 10-DEC-2024
DEFINITION  oncomodulin [Mus musculus].
ACCESSION   NP_149028 XP_001001609
VERSION     NP_149028.2
DBSOURCE    REFSEQ: accession NM_033039.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 109)
  AUTHORS   Lachgar-Ruiz,M., Ingham,N.J., Martelletti,E., Chen,J., James,E.,
            Panganiban,C., Lewis,M.A. and Steel,K.P.
  TITLE     Two new mouse alleles of Ocm and Slc26a5
  JOURNAL   Hear Res 452, 109109 (2024)
   PUBMED   39241555
REFERENCE   2  (residues 1 to 109)
  AUTHORS   Goodrich,E.J. and Deans,M.R.
  TITLE     Emx2 lineage tracing reveals antecedent patterns of planar polarity
            in the mouse inner ear
  JOURNAL   Development 151 (10) (2024)
   PUBMED   38682291
REFERENCE   3  (residues 1 to 109)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 109)
  AUTHORS   Yang,Y., Murtha,K., Climer,L.K., Ceriani,F., Thompson,P.,
            Hornak,A.J., Marcotti,W. and Simmons,D.D.
  TITLE     Oncomodulin regulates spontaneous calcium signalling and maturation
            of afferent innervation in cochlear outer hair cells
  JOURNAL   J Physiol 601 (19), 4291-4308 (2023)
   PUBMED   37642186
  REMARK    GeneRIF: Oncomodulin regulates spontaneous calcium signalling and
            maturation of afferent innervation in cochlear outer hair cells.
REFERENCE   5  (residues 1 to 109)
  AUTHORS   Kwon,M.J., Seo,Y., Cho,H., Kim,H.S., Oh,Y.J., Geniscan,S., Kim,M.,
            Park,H.H., Joe,E.H., Kwon,M.H., Kang,H.C. and Kim,B.G.
  TITLE     Nanogel-mediated delivery of oncomodulin secreted from
            regeneration-associated macrophages promotes sensory axon
            regeneration in the spinal cord
  JOURNAL   Theranostics 12 (13), 5856-5876 (2022)
   PUBMED   35966584
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 109)
  AUTHORS   Hsiao,C.D., Tsai,W.Y. and Tsai,H.J.
  TITLE     Isolation and expression of two zebrafish homologues of parvalbumin
            genes related to chicken CPV3 and mammalian oncomodulin
  JOURNAL   Mech Dev 119 Suppl 1, S161-S166 (2002)
   PUBMED   14516679
REFERENCE   7  (residues 1 to 109)
  AUTHORS   Staubli,F., Klein,A., Rentsch,J.M., Hameister,H. and Berchtold,M.W.
  TITLE     Structure and chromosomal localization of the mouse oncomodulin
            gene
  JOURNAL   Mamm Genome 6 (11), 769-777 (1995)
   PUBMED   8597631
REFERENCE   8  (residues 1 to 109)
  AUTHORS   Ritzler,J.M., Sawhney,R., Geurts van Kessel,A.H., Grzeschik,K.H.,
            Schinzel,A. and Berchtold,M.W.
  TITLE     The genes for the highly homologous Ca(2+)-binding proteins
            oncomodulin and parvalbumin are not linked in the human genome
  JOURNAL   Genomics 12 (3), 567-572 (1992)
   PUBMED   1559707
REFERENCE   9  (residues 1 to 109)
  AUTHORS   Banville,D., Rotaru,M. and Boie,Y.
  TITLE     The intracisternal A particle derived solo LTR promoter of the rat
            oncomodulin gene is not present in the mouse gene
  JOURNAL   Genetica 86 (1-3), 85-97 (1992)
   PUBMED   1468649
REFERENCE   10 (residues 1 to 109)
  AUTHORS   Banville,D. and Boie,Y.
  TITLE     Retroviral long terminal repeat is the promoter of the gene
            encoding the tumor-associated calcium-binding protein oncomodulin
            in the rat
  JOURNAL   J Mol Biol 207 (3), 481-490 (1989)
   PUBMED   2474657
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121917.2.
            
            On Apr 14, 2007 this sequence version replaced NP_149028.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EL956645.1, ERR3363658.3031409.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..109
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 82.85 cM"
     Protein         1..109
                     /product="oncomodulin"
                     /note="OM; parvalbumin beta"
                     /calculated_mol_wt=12129
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:P02631; propagated from
                     UniProtKB/Swiss-Prot (P51879.2)"
     Region          9..109
                     /region_name="EFh_parvalbumin_beta"
                     /note="EF-hand, calcium binding motif, found in
                     beta-parvalbumin; cd16255"
                     /db_xref="CDD:319998"
     Region          9..38
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:319998"
     Region          43..72
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:319998"
     Site            order(52,54,56,60,63,91,93,95,102)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:319998"
     Region          82..109
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:319998"
     Region          82..109
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P51879.2)"
     CDS             1..109
                     /gene="Ocm"
                     /coded_by="NM_033039.3:137..466"
                     /db_xref="CCDS:CCDS51693.1"
                     /db_xref="GeneID:18261"
                     /db_xref="MGI:MGI:97401"
ORIGIN      
        1 msitdilsad diaaalqecq dpdtfepqkf fqtsglskms asqlkdifqf idndqsgyld
       61 edelkyflqr fqsdarelte setkslmdaa dndgdgkiga defqemvhs
//
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