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NCBI Reference Sequence: NP_113996.2
Identical Proteins FASTA Graphics
LOCUS NP_113996 641 aa linear ROD 26-APR-2024 DEFINITION calpain-6 [Rattus norvegicus]. ACCESSION NP_113996 XP_346870 VERSION NP_113996.2 DBSOURCE REFSEQ: accession NM_031808.2 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (residues 1 to 641) AUTHORS Tonami,K., Kurihara,Y., Aburatani,H., Uchijima,Y., Asano,T. and Kurihara,H. TITLE Calpain 6 is involved in microtubule stabilization and cytoskeletal organization JOURNAL Mol Cell Biol 27 (7), 2548-2561 (2007) PUBMED 17210638 REFERENCE 2 (residues 1 to 641) AUTHORS Markmann,A., Schafer,S., Linz,W., Lohn,M., Busch,A.E. and Wohlfart,P. TITLE Down-regulation of calpain 9 is linked to hypertensive heart and kidney disease JOURNAL Cell Physiol Biochem 15 (1-4), 109-116 (2005) PUBMED 15665521 REFERENCE 3 (residues 1 to 641) AUTHORS Shimizu,T., Kawakita,S., Li,Q.H., Fukuhara,S. and Fujisawa,J. TITLE Human T-cell leukemia virus type 1 Tax protein stimulates the interferon-responsive enhancer element via NF-kappaB activity JOURNAL FEBS Lett 539 (1-3), 73-77 (2003) PUBMED 12650929 REFERENCE 4 (residues 1 to 641) AUTHORS Matena,K., Boehm,T. and Dear,N. TITLE Genomic organization of mouse Capn5 and Capn6 genes confirms that they are a distinct calpain subfamily JOURNAL Genomics 48 (1), 117-120 (1998) PUBMED 9503024 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAXUCZ010000021.1. On Nov 26, 2020 this sequence version replaced NP_113996.1. ##Evidence-Data-START## Transcript exon combination :: AF067793.1, SRR26643294.63016.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## FEATURES Location/Qualifiers source 1..641 /organism="Rattus norvegicus" /strain="BN" /db_xref="taxon:10116" /chromosome="X" /map="Xq33" Protein 1..641 /product="calpain-6" /calculated_mol_wt=74442 Region 13..351 /region_name="CysPc" /note="Calpain-like thiol protease family; smart00230" /db_xref="CDD:128526" Site order(81,252,284) /site_type="active" /note="catalytic site [active]" /db_xref="CDD:238004" Region 344..495 /region_name="Domain III" /note="propagated from UniProtKB/Swiss-Prot (O88501.1)" Region 349..497 /region_name="Calpain_III" /note="Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are...; cd00214" /db_xref="CDD:238132" Region 514..639 /region_name="C2_Calpain" /note="C2 domain present in Calpain proteins; cd04046" /db_xref="CDD:176011" CDS 1..641 /gene="Capn6" /coded_by="NM_031808.2:160..2085" /db_xref="GeneID:83685" /db_xref="RGD:70960" ORIGIN 1 mgpplklfkn qkyqelkqdc mkdgrlfcdp tflpendslf fnrllpgkvv wkrpqdisdd 61 phlivgnisn hqliqgrlgn kamisafscl avqeshwtka ipnhkeqewd prkpekyagi 121 frfrfwhfge wtevviddll ptingdlvfs fstsmnefwn allekayakl lgcyealdgl 181 titdiimdft gtlaeiidmq kgrytdlvee kyklfgelyk tftkgglisc siespsqeeq 241 evetdwgllk gytytmtdir klrlgerlve vfsteklymv rlrnplgrqe wsgpwseise 301 ewqqltvtdr knlglvmsdd gefwmsledf chnfhklnvc rnvnnpvfgr kelesvvgcw 361 tvdddplmnr sggcynnrdt flqnpqyift vpedghkvim slqqkdlrty rrmgrpdnyi 421 igfelfkvem nrrfrlhhly iqeragtsty idtrtvflsk ylkkgnyvlv ptmfqhgrts 481 efllrifsev pvqlreltld mpkmscwnla rgypkvvtqi tvhsaeglek kyanetvnpy 541 liikcgkeev rspvqkntvh aifdtqaify rrttdipiii qvwnsrkfcd qflgqvtlda 601 dpsdcrdlks lylrkkggpt akvkqghisf kvissddlte l //
Whole sequence Selected region from: to:
Conserved Domains
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