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calpain-6 [Rattus norvegicus]

NCBI Reference Sequence: NP_113996.2

Identical Proteins FASTA Graphics 

LOCUS       NP_113996                641 aa            linear   ROD 26-APR-2024
DEFINITION  calpain-6 [Rattus norvegicus].
ACCESSION   NP_113996 XP_346870
VERSION     NP_113996.2
DBSOURCE    REFSEQ: accession NM_031808.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 641)
  AUTHORS   Tonami,K., Kurihara,Y., Aburatani,H., Uchijima,Y., Asano,T. and
            Kurihara,H.
  TITLE     Calpain 6 is involved in microtubule stabilization and cytoskeletal
            organization
  JOURNAL   Mol Cell Biol 27 (7), 2548-2561 (2007)
   PUBMED   17210638
REFERENCE   2  (residues 1 to 641)
  AUTHORS   Markmann,A., Schafer,S., Linz,W., Lohn,M., Busch,A.E. and
            Wohlfart,P.
  TITLE     Down-regulation of calpain 9 is linked to hypertensive heart and
            kidney disease
  JOURNAL   Cell Physiol Biochem 15 (1-4), 109-116 (2005)
   PUBMED   15665521
REFERENCE   3  (residues 1 to 641)
  AUTHORS   Shimizu,T., Kawakita,S., Li,Q.H., Fukuhara,S. and Fujisawa,J.
  TITLE     Human T-cell leukemia virus type 1 Tax protein stimulates the
            interferon-responsive enhancer element via NF-kappaB activity
  JOURNAL   FEBS Lett 539 (1-3), 73-77 (2003)
   PUBMED   12650929
REFERENCE   4  (residues 1 to 641)
  AUTHORS   Matena,K., Boehm,T. and Dear,N.
  TITLE     Genomic organization of mouse Capn5 and Capn6 genes confirms that
            they are a distinct calpain subfamily
  JOURNAL   Genomics 48 (1), 117-120 (1998)
   PUBMED   9503024
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Nov 26, 2020 this sequence version replaced NP_113996.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF067793.1, SRR26643294.63016.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..641
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq33"
     Protein         1..641
                     /product="calpain-6"
                     /calculated_mol_wt=74442
     Region          13..351
                     /region_name="CysPc"
                     /note="Calpain-like thiol protease family; smart00230"
                     /db_xref="CDD:128526"
     Site            order(81,252,284)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:238004"
     Region          344..495
                     /region_name="Domain III"
                     /note="propagated from UniProtKB/Swiss-Prot (O88501.1)"
     Region          349..497
                     /region_name="Calpain_III"
                     /note="Calpain, subdomain III. Calpains are
                     calcium-activated cytoplasmic cysteine proteinases,
                     participate in cytoskeletal remodeling processes, cell
                     differentiation, apoptosis and signal transduction.
                     Catalytic domain and the two calmodulin-like domains
                     are...; cd00214"
                     /db_xref="CDD:238132"
     Region          514..639
                     /region_name="C2_Calpain"
                     /note="C2 domain present in Calpain proteins; cd04046"
                     /db_xref="CDD:176011"
     CDS             1..641
                     /gene="Capn6"
                     /coded_by="NM_031808.2:160..2085"
                     /db_xref="GeneID:83685"
                     /db_xref="RGD:70960"
ORIGIN      
        1 mgpplklfkn qkyqelkqdc mkdgrlfcdp tflpendslf fnrllpgkvv wkrpqdisdd
       61 phlivgnisn hqliqgrlgn kamisafscl avqeshwtka ipnhkeqewd prkpekyagi
      121 frfrfwhfge wtevviddll ptingdlvfs fstsmnefwn allekayakl lgcyealdgl
      181 titdiimdft gtlaeiidmq kgrytdlvee kyklfgelyk tftkgglisc siespsqeeq
      241 evetdwgllk gytytmtdir klrlgerlve vfsteklymv rlrnplgrqe wsgpwseise
      301 ewqqltvtdr knlglvmsdd gefwmsledf chnfhklnvc rnvnnpvfgr kelesvvgcw
      361 tvdddplmnr sggcynnrdt flqnpqyift vpedghkvim slqqkdlrty rrmgrpdnyi
      421 igfelfkvem nrrfrlhhly iqeragtsty idtrtvflsk ylkkgnyvlv ptmfqhgrts
      481 efllrifsev pvqlreltld mpkmscwnla rgypkvvtqi tvhsaeglek kyanetvnpy
      541 liikcgkeev rspvqkntvh aifdtqaify rrttdipiii qvwnsrkfcd qflgqvtlda
      601 dpsdcrdlks lylrkkggpt akvkqghisf kvissddlte l
//
Feature
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Reference sequence information

  • RefSeq mRNA
    See reference mRNA sequence for the Capn6 gene (NM_031808.2).

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