deoxyhypusine hydroxylase [Homo sapiens]

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Bi-allelic variants in DOHH, catalyzing the last step of hypusine biosynthesis, are associated with a neurodevelopmental disorder. [Am J Hum Genet. 2022]
Bi-allelic variants in DOHH, catalyzing the last step of hypusine biosynthesis, are associated with a neurodevelopmental disorder.
Ziegler A, Steindl K, Hanner AS, Kar RK, Prouteau C, Boland A, Deleuze JF, Coubes C, Bézieau S, Küry S, et al. Am J Hum Genet. 2022 Aug 4; 109(8):1549-1558. Epub 2022 Jul 19.
Deoxyhypusine hydroxylase as a novel pharmacological target for ischemic stroke via inducing a unique post-translational hypusination modification. [Pharmacol Res. 2022]
Deoxyhypusine hydroxylase as a novel pharmacological target for ischemic stroke via inducing a unique post-translational hypusination modification.
Guo Q, Zhang YC, Wang W, Wang YQ, Liu Y, Yang Z, Zhao MM, Feng N, Wang YH, Zhang XW, et al. Pharmacol Res. 2022 Feb; 176:106046. Epub 2022 Jan 7.
Deoxyhypusine hydroxylase: A novel therapeutic target differentially expressed in short-term vs long-term survivors of glioblastoma. [Int J Cancer. 2023]
Deoxyhypusine hydroxylase: A novel therapeutic target differentially expressed in short-term vs long-term survivors of glioblastoma.
Ofek P, Yeini E, Arad G, Danilevsky A, Pozzi S, Luna CB, Dangoor SI, Grossman R, Ram Z, Shomron N, et al. Int J Cancer. 2023 Aug 1; 153(3):654-668. Epub 2023 May 4.

RefSeq mRNA
See reference mRNA sequence for the DOHH gene (NM_031304.5).
RefSeq protein isoforms
See 4 reference sequence protein isoforms for the DOHH gene.

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NP_112594 [Domain Mapping of Disease Mut...]
NP_112594
Domain Mapping of Disease Mutations
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