Mutations in the planar cell polarity gene, Fuzzy, are associated with neural tube defects in humans.
Seo JH, Zilber Y, Babayeva S, Liu J, Kyriakopoulos P, De Marco P, Merello E, Capra V, Gros P, Torban E. Hum Mol Genet. 2011 Nov 15; 20(22):4324-33. Epub 2011 Aug 12.