An autoimmune disease risk SNP, rs2281808, in SIRPG is associated with reduced expression of SIRPγ and heightened effector state in human CD8 T-cells.
Sinha S, Borcherding N, Renavikar PS, Crawford MP, Tsalikian E, Tansey M, Shivapour ET, Bittner F, Kamholz J, Olalde H, et al. Sci Rep. 2018 Oct 18; 8(1):15440. Epub 2018 Oct 18.