Creatine kinase-mediated improvement of function in failing mouse hearts provides causal evidence the failing heart is energy starved.
Gupta A, Akki A, Wang Y, Leppo MK, Chacko VP, Foster DB, Caceres V, Shi S, Kirk JA, Su J, et al. J Clin Invest. 2012 Jan; 122(1):291-302. Epub 2011 Dec 27.