U.S. flag

An official website of the United States government

phospholipase DDHD2 [Rattus norvegicus]

NCBI Reference Sequence: NP_001305345.1

Identical Proteins FASTA Graphics 

LOCUS       NP_001305345             699 aa            linear   ROD 24-JUN-2024
DEFINITION  phospholipase DDHD2 [Rattus norvegicus].
ACCESSION   NP_001305345
VERSION     NP_001305345.1
DBSOURCE    REFSEQ: accession NM_001318416.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 699)
  AUTHORS   Araki,M., Ohshima,N., Aso,C., Konishi,A., Obinata,H., Tatei,K. and
            Izumi,T.
  TITLE     Enzymatic characterization of recombinant rat DDHD2: a soluble
            diacylglycerol lipase
  JOURNAL   J Biochem 160 (5), 269-279 (2016)
   PUBMED   27198176
  REMARK    GeneRIF: These results therefore support the idea that DDHD2
            functions as a DG lipase in vivo and produces 2-AG.
REFERENCE   2  (residues 1 to 699)
  AUTHORS   Aso,C., Araki,M., Ohshima,N., Tatei,K., Hirano,T., Obinata,H.,
            Kishi,M., Kishimoto,K., Konishi,A., Goto,F., Sugimoto,H. and
            Izumi,T.
  TITLE     Protein purification and cloning of diacylglycerol lipase from rat
            brain
  JOURNAL   J Biochem 159 (6), 585-597 (2016)
   PUBMED   26790472
  REMARK    GeneRIF: DG lipase activity in the soluble fraction of rat brain is
            derived from DDHD2. DDHD2 is distributed widely in the rat brain.
            Immunohistochemical analysis revealed that DDHD2 is expressed in
            hippocampal neurons, but not in glia.
REFERENCE   3  (residues 1 to 699)
  AUTHORS   Inloes,J.M., Hsu,K.L., Dix,M.M., Viader,A., Masuda,K., Takei,T.,
            Wood,M.R. and Cravatt,B.F.
  TITLE     The hereditary spastic paraplegia-related enzyme DDHD2 is a
            principal brain triglyceride lipase
  JOURNAL   Proc Natl Acad Sci U S A 111 (41), 14924-14929 (2014)
   PUBMED   25267624
REFERENCE   4  (residues 1 to 699)
  AUTHORS   Baba,T., Kashiwagi,Y., Arimitsu,N., Kogure,T., Edo,A., Maruyama,T.,
            Nakao,K., Nakanishi,H., Kinoshita,M., Frohman,M.A., Yamamoto,A. and
            Tani,K.
  TITLE     Phosphatidic acid (PA)-preferring phospholipase A1 regulates
            mitochondrial dynamics
  JOURNAL   J Biol Chem 289 (16), 11497-11511 (2014)
   PUBMED   24599962
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB914679.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB914679.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..699
                     /organism="Rattus norvegicus"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.4"
     Protein         1..699
                     /product="phospholipase DDHD2"
                     /function="lipase"
                     /calculated_mol_wt=79440
     Region          43..112
                     /region_name="WWE"
                     /note="WWE domain; pfam02825"
                     /db_xref="CDD:460715"
     Region          379..447
                     /region_name="SAM_superfamily"
                     /note="SAM (Sterile alpha motif); cl15755"
                     /db_xref="CDD:472832"
     Region          484..687
                     /region_name="DDHD"
                     /note="DDHD domain; pfam02862"
                     /db_xref="CDD:460725"
     CDS             1..699
                     /gene="Ddhd2"
                     /coded_by="NM_001318416.1:62..2161"
                     /db_xref="GeneID:680971"
                     /db_xref="RGD:1585818"
ORIGIN      
        1 mssgesyqeq lsqsdpspsp nssssfelld mdvgssyepv sphwfyckvi dskelwipfn
       61 sedsqqleea hgsgkdcner vvptdggryd vhlgermrya vywdelpsev rrctwfykgd
      121 kdnkyvpyse sfsqvledty mlavtldewk kklespnrei ivlhnpklmv hyqpitgsde
      181 wgststeqgr prsvkrgves ipvdihcgep lqidhlvfvv hgigpacdlr frsivqcvnd
      241 frsvslnllq thfkkaqenq qigrveflpv nwhsplhstg vdidlqritl psinrlrhft
      301 ndtildvffy nsptycqtiv dtvasemnri ytlflqrnpd fkggvsiagh slgslilfdi
      361 ltnqkdsigd idsekgslst aedlgdvstl eeelkklqls efvtvfekek vdrealalct
      421 drdlqemgip lgprkkilnh fsatkssvgi nrptmsasev nipkekgdyl dvgigqvsvk
      481 yprlnykpei ffafgspigm fltvrglrri dpnykfptck gffniyhpfd pvayriepmv
      541 vpgvefepml iphhkgrkrm hlelregltr msmdlknnll gslrmawksf trapypalqa
      601 semaedteae sepssekpsd anteeppvev keeapinvgm lnggqridyv lqekpiesfn
      661 eylfalqshl cywesedtvl lvlkeiyqtq gifldqplq
//
Feature
Display: FASTA GenBank Help
Details

Supplemental Content

Change region shown

Customize view

Reference sequence information

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
External link. Please review our privacy policy.