LOCUS NP_001305345 699 aa linear ROD 24-JUN-2024
DEFINITION phospholipase DDHD2 [Rattus norvegicus].
ACCESSION NP_001305345
VERSION NP_001305345.1
DBSOURCE REFSEQ: accession NM_001318416.1
KEYWORDS RefSeq.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (residues 1 to 699)
AUTHORS Araki,M., Ohshima,N., Aso,C., Konishi,A., Obinata,H., Tatei,K. and
Izumi,T.
TITLE Enzymatic characterization of recombinant rat DDHD2: a soluble
diacylglycerol lipase
JOURNAL J Biochem 160 (5), 269-279 (2016)
PUBMED 27198176
REMARK GeneRIF: These results therefore support the idea that DDHD2
functions as a DG lipase in vivo and produces 2-AG.
REFERENCE 2 (residues 1 to 699)
AUTHORS Aso,C., Araki,M., Ohshima,N., Tatei,K., Hirano,T., Obinata,H.,
Kishi,M., Kishimoto,K., Konishi,A., Goto,F., Sugimoto,H. and
Izumi,T.
TITLE Protein purification and cloning of diacylglycerol lipase from rat
brain
JOURNAL J Biochem 159 (6), 585-597 (2016)
PUBMED 26790472
REMARK GeneRIF: DG lipase activity in the soluble fraction of rat brain is
derived from DDHD2. DDHD2 is distributed widely in the rat brain.
Immunohistochemical analysis revealed that DDHD2 is expressed in
hippocampal neurons, but not in glia.
REFERENCE 3 (residues 1 to 699)
AUTHORS Inloes,J.M., Hsu,K.L., Dix,M.M., Viader,A., Masuda,K., Takei,T.,
Wood,M.R. and Cravatt,B.F.
TITLE The hereditary spastic paraplegia-related enzyme DDHD2 is a
principal brain triglyceride lipase
JOURNAL Proc Natl Acad Sci U S A 111 (41), 14924-14929 (2014)
PUBMED 25267624
REFERENCE 4 (residues 1 to 699)
AUTHORS Baba,T., Kashiwagi,Y., Arimitsu,N., Kogure,T., Edo,A., Maruyama,T.,
Nakao,K., Nakanishi,H., Kinoshita,M., Frohman,M.A., Yamamoto,A. and
Tani,K.
TITLE Phosphatidic acid (PA)-preferring phospholipase A1 regulates
mitochondrial dynamics
JOURNAL J Biol Chem 289 (16), 11497-11511 (2014)
PUBMED 24599962
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from AB914679.1.
##Evidence-Data-START##
Transcript exon combination :: AB914679.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMD00132261, SAMD00132262
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..699
/organism="Rattus norvegicus"
/strain="W"
/db_xref="taxon:10116"
/chromosome="16"
/map="16q12.4"
Protein 1..699
/product="phospholipase DDHD2"
/function="lipase"
/calculated_mol_wt=79440
Region 43..112
/region_name="WWE"
/note="WWE domain; pfam02825"
/db_xref="CDD:460715"
Region 379..447
/region_name="SAM_superfamily"
/note="SAM (Sterile alpha motif); cl15755"
/db_xref="CDD:472832"
Region 484..687
/region_name="DDHD"
/note="DDHD domain; pfam02862"
/db_xref="CDD:460725"
CDS 1..699
/gene="Ddhd2"
/coded_by="NM_001318416.1:62..2161"
/db_xref="GeneID:680971"
/db_xref="RGD:1585818"
ORIGIN
1 mssgesyqeq lsqsdpspsp nssssfelld mdvgssyepv sphwfyckvi dskelwipfn
61 sedsqqleea hgsgkdcner vvptdggryd vhlgermrya vywdelpsev rrctwfykgd
121 kdnkyvpyse sfsqvledty mlavtldewk kklespnrei ivlhnpklmv hyqpitgsde
181 wgststeqgr prsvkrgves ipvdihcgep lqidhlvfvv hgigpacdlr frsivqcvnd
241 frsvslnllq thfkkaqenq qigrveflpv nwhsplhstg vdidlqritl psinrlrhft
301 ndtildvffy nsptycqtiv dtvasemnri ytlflqrnpd fkggvsiagh slgslilfdi
361 ltnqkdsigd idsekgslst aedlgdvstl eeelkklqls efvtvfekek vdrealalct
421 drdlqemgip lgprkkilnh fsatkssvgi nrptmsasev nipkekgdyl dvgigqvsvk
481 yprlnykpei ffafgspigm fltvrglrri dpnykfptck gffniyhpfd pvayriepmv
541 vpgvefepml iphhkgrkrm hlelregltr msmdlknnll gslrmawksf trapypalqa
601 semaedteae sepssekpsd anteeppvev keeapinvgm lnggqridyv lqekpiesfn
661 eylfalqshl cywesedtvl lvlkeiyqtq gifldqplq
//