LOCUS NP_001280688 109 aa linear ROD 30-APR-2024
DEFINITION dynactin subunit 6 isoform 4 [Mus musculus].
ACCESSION NP_001280688 XP_006509159
VERSION NP_001280688.1
DBSOURCE REFSEQ: accession NM_001293759.1
KEYWORDS RefSeq.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (residues 1 to 109)
AUTHORS Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
Jackson,S.P. and Balmus,G.
CONSRTM Sanger Mouse Genetics Project
TITLE Genetic determinants of micronucleus formation in vivo
JOURNAL Nature 627 (8002), 130-136 (2024)
PUBMED 38355793
REFERENCE 2 (residues 1 to 109)
AUTHORS Sharoar,M.G., Zhou,J., Benoit,M., He,W. and Yan,R.
TITLE Dynactin 6 deficiency enhances aging-associated dystrophic neurite
formation in mouse brains
JOURNAL Neurobiol Aging 107, 21-29 (2021)
PUBMED 34371284
REMARK GeneRIF: Dynactin 6 deficiency enhances aging-associated dystrophic
neurite formation in mouse brains.
REFERENCE 3 (residues 1 to 109)
AUTHORS Yeh,T.Y., Kowalska,A.K., Scipioni,B.R., Cheong,F.K., Zheng,M.,
Derewenda,U., Derewenda,Z.S. and Schroer,T.A.
TITLE Dynactin helps target Polo-like kinase 1 to kinetochores via its
left-handed beta-helical p27 subunit
JOURNAL EMBO J 32 (7), 1023-1035 (2013)
PUBMED 23455152
REMARK GeneRIF: Dynactin helps target Polo-like kinase 1 to kinetochores
via its left-handed beta-helical p27 subunit.
REFERENCE 4 (residues 1 to 109)
AUTHORS Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
TITLE The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
JOURNAL Nucleic Acids Res 30 (1), 218-220 (2002)
PUBMED 11752298
REFERENCE 5 (residues 1 to 109)
AUTHORS Eckley,D.M., Gill,S.R., Melkonian,K.A., Bingham,J.B., Goodson,H.V.,
Heuser,J.E. and Schroer,T.A.
TITLE Analysis of dynactin subcomplexes reveals a novel actin-related
protein associated with the arp1 minifilament pointed end
JOURNAL J Cell Biol 147 (2), 307-320 (1999)
PUBMED 10525537
REFERENCE 6 (residues 1 to 109)
AUTHORS Murdock,D.G., Boone,B.E., Esposito,L.A. and Wallace,D.C.
TITLE Up-regulation of nuclear and mitochondrial genes in the skeletal
muscle of mice lacking the heart/muscle isoform of the adenine
nucleotide translocator
JOURNAL J Biol Chem 274 (20), 14429-14433 (1999)
PUBMED 10318868
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
CA573939.1, CV560309.1, AK003618.1 and BU756370.1.
On Jun 19, 2014 this sequence version replaced XP_006509159.1.
Transcript Variant: This variant (4) lacks an alternate exon and
contains another alternate exon compared to variant 1. The
resulting isoform (4) is shorter at the N-terminus compared to
isoform 1.
##Evidence-Data-START##
Transcript exon combination :: CV560309.1, SRR11927938.4139607.1
[ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN00849381, SAMN01164138
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..109
/organism="Mus musculus"
/strain="C57BL/6NCrl"
/db_xref="taxon:10090"
/chromosome="8"
/map="8 20.9 cM"
Protein 1..109
/product="dynactin subunit 6 isoform 4"
/note="RGD containing protein; dynactin subunit 6; protein
WS-3; dynactin subunit p27; p27 dynactin subunit"
/calculated_mol_wt=11927
Region <1..98
/region_name="LbH_Dynactin_6"
/note="Dynactin 6 (or subunit p27): Dynactin is a major
component of the activator complex that stimulates
dynein-mediated vesicle transport. Dynactin is a
heterocomplex of at least eight subunits, including a
150,000-MW protein called Glued, the actin-capping...;
cd04646"
/db_xref="CDD:100052"
CDS 1..109
/gene="Dctn6"
/gene_synonym="p27; WS-3"
/coded_by="NM_001293759.1:698..1027"
/note="isoform 4 is encoded by transcript variant 4"
/db_xref="GeneID:22428"
/db_xref="MGI:MGI:1343154"
ORIGIN
1 miigtnnvfe vgchsqamkm gdnnvieska yvgrnvilts gciigaccsl ntfeaipent
61 viygadclrr vqterpqpqt lqldflmkil pnyhhlkktm kgsstpvkn
//