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dynactin subunit 6 isoform 4 [Mus musculus]

NCBI Reference Sequence: NP_001280688.1

Identical Proteins FASTA Graphics 

LOCUS       NP_001280688             109 aa            linear   ROD 30-APR-2024
DEFINITION  dynactin subunit 6 isoform 4 [Mus musculus].
ACCESSION   NP_001280688 XP_006509159
VERSION     NP_001280688.1
DBSOURCE    REFSEQ: accession NM_001293759.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 109)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 109)
  AUTHORS   Sharoar,M.G., Zhou,J., Benoit,M., He,W. and Yan,R.
  TITLE     Dynactin 6 deficiency enhances aging-associated dystrophic neurite
            formation in mouse brains
  JOURNAL   Neurobiol Aging 107, 21-29 (2021)
   PUBMED   34371284
  REMARK    GeneRIF: Dynactin 6 deficiency enhances aging-associated dystrophic
            neurite formation in mouse brains.
REFERENCE   3  (residues 1 to 109)
  AUTHORS   Yeh,T.Y., Kowalska,A.K., Scipioni,B.R., Cheong,F.K., Zheng,M.,
            Derewenda,U., Derewenda,Z.S. and Schroer,T.A.
  TITLE     Dynactin helps target Polo-like kinase 1 to kinetochores via its
            left-handed beta-helical p27 subunit
  JOURNAL   EMBO J 32 (7), 1023-1035 (2013)
   PUBMED   23455152
  REMARK    GeneRIF: Dynactin helps target Polo-like kinase 1 to kinetochores
            via its left-handed beta-helical p27 subunit.
REFERENCE   4  (residues 1 to 109)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
REFERENCE   5  (residues 1 to 109)
  AUTHORS   Eckley,D.M., Gill,S.R., Melkonian,K.A., Bingham,J.B., Goodson,H.V.,
            Heuser,J.E. and Schroer,T.A.
  TITLE     Analysis of dynactin subcomplexes reveals a novel actin-related
            protein associated with the arp1 minifilament pointed end
  JOURNAL   J Cell Biol 147 (2), 307-320 (1999)
   PUBMED   10525537
REFERENCE   6  (residues 1 to 109)
  AUTHORS   Murdock,D.G., Boone,B.E., Esposito,L.A. and Wallace,D.C.
  TITLE     Up-regulation of nuclear and mitochondrial genes in the skeletal
            muscle of mice lacking the heart/muscle isoform of the adenine
            nucleotide translocator
  JOURNAL   J Biol Chem 274 (20), 14429-14433 (1999)
   PUBMED   10318868
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA573939.1, CV560309.1, AK003618.1 and BU756370.1.
            
            On Jun 19, 2014 this sequence version replaced XP_006509159.1.
            
            Transcript Variant: This variant (4) lacks an alternate exon and
            contains another alternate exon compared to variant 1. The
            resulting isoform (4) is shorter at the N-terminus compared to
            isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CV560309.1, SRR11927938.4139607.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..109
                     /organism="Mus musculus"
                     /strain="C57BL/6NCrl"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 20.9 cM"
     Protein         1..109
                     /product="dynactin subunit 6 isoform 4"
                     /note="RGD containing protein; dynactin subunit 6; protein
                     WS-3; dynactin subunit p27; p27 dynactin subunit"
                     /calculated_mol_wt=11927
     Region          <1..98
                     /region_name="LbH_Dynactin_6"
                     /note="Dynactin 6 (or subunit p27): Dynactin is a major
                     component of the activator complex that stimulates
                     dynein-mediated vesicle transport. Dynactin is a
                     heterocomplex of at least eight subunits, including a
                     150,000-MW protein called Glued, the actin-capping...;
                     cd04646"
                     /db_xref="CDD:100052"
     CDS             1..109
                     /gene="Dctn6"
                     /gene_synonym="p27; WS-3"
                     /coded_by="NM_001293759.1:698..1027"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /db_xref="GeneID:22428"
                     /db_xref="MGI:MGI:1343154"
ORIGIN      
        1 miigtnnvfe vgchsqamkm gdnnvieska yvgrnvilts gciigaccsl ntfeaipent
       61 viygadclrr vqterpqpqt lqldflmkil pnyhhlkktm kgsstpvkn
//
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