Major spliceosome defects cause male infertility and are associated with nonobstructive azoospermia in humans.
Wu H, Sun L, Wen Y, Liu Y, Yu J, Mao F, Wang Y, Tong C, Guo X, Hu Z, et al. Proc Natl Acad Sci U S A. 2016 Apr 12; 113(15):4134-9. Epub 2016 Mar 28.