LOCUS NP_001163943 922 aa linear ROD 31-MAR-2024
DEFINITION cell cycle and apoptosis regulator protein 2 [Rattus norvegicus].
ACCESSION NP_001163943 XP_001069514 XP_224329
VERSION NP_001163943.1
DBSOURCE REFSEQ: accession NM_001170472.2
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (residues 1 to 922)
AUTHORS Sakurabashi,A., Wada-Hiraike,O., Hirano,M., Fu,H., Isono,W.,
Fukuda,T., Morita,Y., Tanikawa,M., Miyamoto,Y., Oda,K., Kawana,K.,
Osuga,Y. and Fujii,T.
TITLE CCAR2 negatively regulates nuclear receptor LXRalpha by competing
with SIRT1 deacetylase
JOURNAL J Steroid Biochem Mol Biol 149, 80-88 (2015)
PUBMED 25661920
REFERENCE 2 (residues 1 to 922)
AUTHORS Pangon,L., Mladenova,D., Watkins,L., Van Kralingen,C., Currey,N.,
Al-Sohaily,S., Lecine,P., Borg,J.P. and Kohonen-Corish,M.R.
TITLE MCC inhibits beta-catenin transcriptional activity by sequestering
DBC1 in the cytoplasm
JOURNAL Int J Cancer 136 (1), 55-64 (2015)
PUBMED 24824780
REFERENCE 3 (residues 1 to 922)
AUTHORS Kim,W. and Kim,J.E.
TITLE Deleted in breast cancer 1 (DBC1) deficiency results in apoptosis
of breast cancer cells through impaired responses to UV-induced DNA
damage
JOURNAL Cancer Lett 333 (2), 180-186 (2013)
PUBMED 23352644
REFERENCE 4 (residues 1 to 922)
AUTHORS Chini,C.C., Escande,C., Nin,V. and Chini,E.N.
TITLE DBC1 (Deleted in Breast Cancer 1) modulates the stability and
function of the nuclear receptor Rev-erbalpha
JOURNAL Biochem J 451 (3), 453-461 (2013)
PUBMED 23398316
REFERENCE 5 (residues 1 to 922)
AUTHORS Armour,S.M., Bennett,E.J., Braun,C.R., Zhang,X.Y., McMahon,S.B.,
Gygi,S.P., Harper,J.W. and Sinclair,D.A.
TITLE A high-confidence interaction map identifies SIRT1 as a mediator of
acetylation of USP22 and the SAGA coactivator complex
JOURNAL Mol Cell Biol 33 (8), 1487-1502 (2013)
PUBMED 23382074
REFERENCE 6 (residues 1 to 922)
AUTHORS Koyama,S., Wada-Hiraike,O., Nakagawa,S., Tanikawa,M., Hiraike,H.,
Miyamoto,Y., Sone,K., Oda,K., Fukuhara,H., Nakagawa,K., Kato,S.,
Yano,T. and Taketani,Y.
TITLE Repression of estrogen receptor beta function by putative tumor
suppressor DBC1
JOURNAL Biochem Biophys Res Commun 392 (3), 357-362 (2010)
PUBMED 20074560
REFERENCE 7 (residues 1 to 922)
AUTHORS Li,Z., Chen,L., Kabra,N., Wang,C., Fang,J. and Chen,J.
TITLE Inhibition of SUV39H1 methyltransferase activity by DBC1
JOURNAL J Biol Chem 284 (16), 10361-10366 (2009)
PUBMED 19218236
REFERENCE 8 (residues 1 to 922)
AUTHORS Zhao,W., Kruse,J.P., Tang,Y., Jung,S.Y., Qin,J. and Gu,W.
TITLE Negative regulation of the deacetylase SIRT1 by DBC1
JOURNAL Nature 451 (7178), 587-590 (2008)
PUBMED 18235502
REFERENCE 9 (residues 1 to 922)
AUTHORS Kim,J.E., Chen,J. and Lou,Z.
TITLE DBC1 is a negative regulator of SIRT1
JOURNAL Nature 451 (7178), 583-586 (2008)
PUBMED 18235501
REFERENCE 10 (residues 1 to 922)
AUTHORS Sundararajan,R., Chen,G., Mukherjee,C. and White,E.
TITLE Caspase-dependent processing activates the proapoptotic activity of
deleted in breast cancer-1 during tumor necrosis
factor-alpha-mediated death signaling
JOURNAL Oncogene 24 (31), 4908-4920 (2005)
PUBMED 15824730
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
JAXUCZ010000015.1.
On or before Dec 20, 2009 this sequence version replaced
XP_224329.4, XP_001069514.1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data from several strains because no single
transcript was available for the full length of the gene. The
extent of this transcript is supported by transcript alignments and
orthologous data.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: FQ211644.1, SRR26643298.57805.1
[ECO:0000332]
RNAseq introns :: mixed sample support SAMEA5760383,
SAMEA5760386 [ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..922
/organism="Rattus norvegicus"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="15"
/map="15p11"
Protein 1..922
/product="cell cycle and apoptosis regulator protein 2"
/calculated_mol_wt=102662
Region 55..112
/region_name="S1-like"
/note="pfam14444"
/db_xref="CDD:464176"
Region 234..315
/region_name="BURAN"
/note="BURAN domain; pfam19257"
/db_xref="CDD:466013"
Region 340..457
/region_name="DBC1"
/note="pfam14443"
/db_xref="CDD:464175"
Region <511..559
/region_name="LAIKA"
/note="LAIKA domain; pfam19256"
/db_xref="CDD:466012"
Region <813..>917
/region_name="SMC_prok_B"
/note="chromosome segregation protein SMC, common
bacterial type; TIGR02168"
/db_xref="CDD:274008"
CDS 1..922
/gene="Ccar2"
/gene_synonym="RGD1309922"
/coded_by="NM_001170472.2:110..2878"
/db_xref="GeneID:306007"
/db_xref="RGD:1309922"
ORIGIN
1 msqfkrqrin plpggrnfsg aastsllgpp pglltppvat dlsqnarhlq sgekqrvftg
61 ivtslhdyfg vvdeevffql svvkgrlpql gekvlvkaay npgqavpwna vkvqtlsnqp
121 llkspappll hvaalgqkqg ilgaqpqlif qphripplfp qkplslfqts htlhlshlnr
181 fpargphgrl dqgrsddyds kkrkqragge pwgakkprhd lppyrvhltp yavdsptcdf
241 lelqrryrsl lvpsdflsvh lswlsafplg qpfslhhpsr iqvssekeaa pdtgaepspe
301 dsdptysskv lllsspglee fyrccmlfvd dmaepretpe hplkqlkfll grkeeeavlv
361 ggewspsldg ldpqadpqvl vrtaircaqa qtgidlstct kwwrfaefqy lqpgpprqlh
421 tvvvylpdvw timptleewe alcqqkatea apqpqeasge aeateqapdv seqadtskqd
481 tetaeattqq dvdtelpeap ppplepavma rpgcvnlsly givedrrpke risfevvvla
541 elfvemlqrd fgyriykvll slpekvvspp epekeeaake dvvkeeeavk eeavkvskde
601 vqnegtaaea dsplkedgll pkqpsaggee eekargeaae dlcemaldpd llllrddgee
661 efagakleet evrsvasnqs emeysslqdm pkeldpsavl pldcllafvf fdanwcgylh
721 rrdlerillt lgirlsaeqa kqlvsrvvaq nicqyrslqy sraealddgl pedvlfgnld
781 llppsgkstk pgaaptehkg lvphngslin vgsllqraeq qdsgrlylen kihtlelkle
841 eshnrfsate vtnktlaaem qelrarlaea eetartverq knqlqrqmqd frrrltplhl
901 emqrivekad swvekeeptp sn
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