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cell cycle and apoptosis regulator protein 2 [Rattus norvegicus]

NCBI Reference Sequence: NP_001163943.1

Identical Proteins FASTA Graphics 

LOCUS       NP_001163943             922 aa            linear   ROD 31-MAR-2024
DEFINITION  cell cycle and apoptosis regulator protein 2 [Rattus norvegicus].
ACCESSION   NP_001163943 XP_001069514 XP_224329
VERSION     NP_001163943.1
DBSOURCE    REFSEQ: accession NM_001170472.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 922)
  AUTHORS   Sakurabashi,A., Wada-Hiraike,O., Hirano,M., Fu,H., Isono,W.,
            Fukuda,T., Morita,Y., Tanikawa,M., Miyamoto,Y., Oda,K., Kawana,K.,
            Osuga,Y. and Fujii,T.
  TITLE     CCAR2 negatively regulates nuclear receptor LXRalpha by competing
            with SIRT1 deacetylase
  JOURNAL   J Steroid Biochem Mol Biol 149, 80-88 (2015)
   PUBMED   25661920
REFERENCE   2  (residues 1 to 922)
  AUTHORS   Pangon,L., Mladenova,D., Watkins,L., Van Kralingen,C., Currey,N.,
            Al-Sohaily,S., Lecine,P., Borg,J.P. and Kohonen-Corish,M.R.
  TITLE     MCC inhibits beta-catenin transcriptional activity by sequestering
            DBC1 in the cytoplasm
  JOURNAL   Int J Cancer 136 (1), 55-64 (2015)
   PUBMED   24824780
REFERENCE   3  (residues 1 to 922)
  AUTHORS   Kim,W. and Kim,J.E.
  TITLE     Deleted in breast cancer 1 (DBC1) deficiency results in apoptosis
            of breast cancer cells through impaired responses to UV-induced DNA
            damage
  JOURNAL   Cancer Lett 333 (2), 180-186 (2013)
   PUBMED   23352644
REFERENCE   4  (residues 1 to 922)
  AUTHORS   Chini,C.C., Escande,C., Nin,V. and Chini,E.N.
  TITLE     DBC1 (Deleted in Breast Cancer 1) modulates the stability and
            function of the nuclear receptor Rev-erbalpha
  JOURNAL   Biochem J 451 (3), 453-461 (2013)
   PUBMED   23398316
REFERENCE   5  (residues 1 to 922)
  AUTHORS   Armour,S.M., Bennett,E.J., Braun,C.R., Zhang,X.Y., McMahon,S.B.,
            Gygi,S.P., Harper,J.W. and Sinclair,D.A.
  TITLE     A high-confidence interaction map identifies SIRT1 as a mediator of
            acetylation of USP22 and the SAGA coactivator complex
  JOURNAL   Mol Cell Biol 33 (8), 1487-1502 (2013)
   PUBMED   23382074
REFERENCE   6  (residues 1 to 922)
  AUTHORS   Koyama,S., Wada-Hiraike,O., Nakagawa,S., Tanikawa,M., Hiraike,H.,
            Miyamoto,Y., Sone,K., Oda,K., Fukuhara,H., Nakagawa,K., Kato,S.,
            Yano,T. and Taketani,Y.
  TITLE     Repression of estrogen receptor beta function by putative tumor
            suppressor DBC1
  JOURNAL   Biochem Biophys Res Commun 392 (3), 357-362 (2010)
   PUBMED   20074560
REFERENCE   7  (residues 1 to 922)
  AUTHORS   Li,Z., Chen,L., Kabra,N., Wang,C., Fang,J. and Chen,J.
  TITLE     Inhibition of SUV39H1 methyltransferase activity by DBC1
  JOURNAL   J Biol Chem 284 (16), 10361-10366 (2009)
   PUBMED   19218236
REFERENCE   8  (residues 1 to 922)
  AUTHORS   Zhao,W., Kruse,J.P., Tang,Y., Jung,S.Y., Qin,J. and Gu,W.
  TITLE     Negative regulation of the deacetylase SIRT1 by DBC1
  JOURNAL   Nature 451 (7178), 587-590 (2008)
   PUBMED   18235502
REFERENCE   9  (residues 1 to 922)
  AUTHORS   Kim,J.E., Chen,J. and Lou,Z.
  TITLE     DBC1 is a negative regulator of SIRT1
  JOURNAL   Nature 451 (7178), 583-586 (2008)
   PUBMED   18235501
REFERENCE   10 (residues 1 to 922)
  AUTHORS   Sundararajan,R., Chen,G., Mukherjee,C. and White,E.
  TITLE     Caspase-dependent processing activates the proapoptotic activity of
            deleted in breast cancer-1 during tumor necrosis
            factor-alpha-mediated death signaling
  JOURNAL   Oncogene 24 (31), 4908-4920 (2005)
   PUBMED   15824730
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On or before Dec 20, 2009 this sequence version replaced
            XP_224329.4, XP_001069514.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data from several strains because no single
            transcript was available for the full length of the gene. The
            extent of this transcript is supported by transcript alignments and
            orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ211644.1, SRR26643298.57805.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..922
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p11"
     Protein         1..922
                     /product="cell cycle and apoptosis regulator protein 2"
                     /calculated_mol_wt=102662
     Region          55..112
                     /region_name="S1-like"
                     /note="pfam14444"
                     /db_xref="CDD:464176"
     Region          234..315
                     /region_name="BURAN"
                     /note="BURAN domain; pfam19257"
                     /db_xref="CDD:466013"
     Region          340..457
                     /region_name="DBC1"
                     /note="pfam14443"
                     /db_xref="CDD:464175"
     Region          <511..559
                     /region_name="LAIKA"
                     /note="LAIKA domain; pfam19256"
                     /db_xref="CDD:466012"
     Region          <813..>917
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..922
                     /gene="Ccar2"
                     /gene_synonym="RGD1309922"
                     /coded_by="NM_001170472.2:110..2878"
                     /db_xref="GeneID:306007"
                     /db_xref="RGD:1309922"
ORIGIN      
        1 msqfkrqrin plpggrnfsg aastsllgpp pglltppvat dlsqnarhlq sgekqrvftg
       61 ivtslhdyfg vvdeevffql svvkgrlpql gekvlvkaay npgqavpwna vkvqtlsnqp
      121 llkspappll hvaalgqkqg ilgaqpqlif qphripplfp qkplslfqts htlhlshlnr
      181 fpargphgrl dqgrsddyds kkrkqragge pwgakkprhd lppyrvhltp yavdsptcdf
      241 lelqrryrsl lvpsdflsvh lswlsafplg qpfslhhpsr iqvssekeaa pdtgaepspe
      301 dsdptysskv lllsspglee fyrccmlfvd dmaepretpe hplkqlkfll grkeeeavlv
      361 ggewspsldg ldpqadpqvl vrtaircaqa qtgidlstct kwwrfaefqy lqpgpprqlh
      421 tvvvylpdvw timptleewe alcqqkatea apqpqeasge aeateqapdv seqadtskqd
      481 tetaeattqq dvdtelpeap ppplepavma rpgcvnlsly givedrrpke risfevvvla
      541 elfvemlqrd fgyriykvll slpekvvspp epekeeaake dvvkeeeavk eeavkvskde
      601 vqnegtaaea dsplkedgll pkqpsaggee eekargeaae dlcemaldpd llllrddgee
      661 efagakleet evrsvasnqs emeysslqdm pkeldpsavl pldcllafvf fdanwcgylh
      721 rrdlerillt lgirlsaeqa kqlvsrvvaq nicqyrslqy sraealddgl pedvlfgnld
      781 llppsgkstk pgaaptehkg lvphngslin vgsllqraeq qdsgrlylen kihtlelkle
      841 eshnrfsate vtnktlaaem qelrarlaea eetartverq knqlqrqmqd frrrltplhl
      901 emqrivekad swvekeeptp sn
//
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