hydroxymethylglutaryl-CoA synthase, mitochondrial isoform 2 precursor - Protein

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BET inhibition decreases HMGCS2 and sensitizes resistant pancreatic tumors to gemcitabine. [Cancer Lett. 2024]
BET inhibition decreases HMGCS2 and sensitizes resistant pancreatic tumors to gemcitabine.
Miller AL, Fehling SC, Vance RB, Chen D, Brown EJ, Hossain MI, Heard EO, Andrabi SA, Wang H, Yang ES, et al. Cancer Lett. 2024 Jun 28; 592:216919. Epub 2024 May 3.
HMGCS2 serves as a potential biomarker for inhibition of renal clear cell carcinoma growth. [Sci Rep. 2023]
HMGCS2 serves as a potential biomarker for inhibition of renal clear cell carcinoma growth.
Mao H, Wang R, Shao F, Zhao M, Tian D, Xia H, Zhao Y. Sci Rep. 2023 Sep 5; 13(1):14629. Epub 2023 Sep 5.
Epigenetic inactivation of hydroxymethylglutaryl CoA synthase reduces ketogenesis and facilitates tumor cell motility in clear cell renal carcinoma. [Pathol Res Pract. 2021]
Epigenetic inactivation of hydroxymethylglutaryl CoA synthase reduces ketogenesis and facilitates tumor cell motility in clear cell renal carcinoma.
Han P, Wang Y, Luo W, Lu Y, Zhou X, Yang Y, Zheng Q, Li D, Wu S, Li L, et al. Pathol Res Pract. 2021 Nov; 227:153622. Epub 2021 Sep 20.

RefSeq genomic sequence
See the genomic reference sequence for the HMGCS2 gene (NG_013348.1).
RefSeq mRNA
See reference mRNA sequence for the HMGCS2 gene (NM_001166107.1).
RefSeq protein isoforms
See the other reference sequence protein isoform for the HMGCS2 gene (NP_005509.1).

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Ensembl [Ensembl]
Ensembl
GlyGen glycoinformatics resource [GlyGen glycoinformatics resou...]
GlyGen glycoinformatics resource
hydroxymethylglutaryl-CoA synthase 2 protein [Guide to Pharmacology]
hydroxymethylglutaryl-CoA synthase 2 protein
Guide to Pharmacology
OncoMX cancer biomarker resource [OncoMX cancer biomarker resou...]
OncoMX cancer biomarker resource
Transcript/Protein Information [PANTHER Classification System]
Transcript/Protein Information
PANTHER Classification System
reagents [ExactAntigen/Labome]
reagents
ExactAntigen/Labome
reagent reviews [ExactAntigen/Labome]
reagent reviews
ExactAntigen/Labome
Evolutionary Trace of Functional Site [Evolutionary Trace of Functio...]
Evolutionary Trace of Functional Site

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Protein