polymerase (DNA-directed), epsilon 4 (p12 subunit), isoform CRA_b [Hom - Protein

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Loss of POLE3-POLE4 unleashes replicative gap accumulation upon treatment with PARP inhibitors. [Cell Rep. 2024]
Loss of POLE3-POLE4 unleashes replicative gap accumulation upon treatment with PARP inhibitors.
Hill BR, Ozgencil M, Buckley-Benbow L, Skingsley SLP, Tomlinson D, Eizmendi CO, Agnarelli A, Bellelli R. Cell Rep. 2024 May 28; 43(5):114205. Epub 2024 May 15.
POLE3-POLE4 Is a Histone H3-H4 Chaperone that Maintains Chromatin Integrity during DNA Replication. [Mol Cell. 2018]
POLE3-POLE4 Is a Histone H3-H4 Chaperone that Maintains Chromatin Integrity during DNA Replication.
Bellelli R, Belan O, Pye VE, Clement C, Maslen SL, Skehel JM, Cherepanov P, Almouzni G, Boulton SJ. Mol Cell. 2018 Oct 4; 72(1):112-126.e5. Epub 2018 Sep 11.
Kinetic investigation of the polymerase and exonuclease activities of human DNA polymerase ε holoenzyme. [J Biol Chem. 2020]
Kinetic investigation of the polymerase and exonuclease activities of human DNA polymerase ε holoenzyme.
Zahurancik WJ, Suo Z. J Biol Chem. 2020 Dec 11; 295(50):17251-17264. Epub 2020 Oct 13.

RefSeq protein
See the reference protein sequence for DNA polymerase epsilon subunit 4 (NP_063949.2).

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