LOCUS CAA59427 733 aa linear PRI 21-OCT-2008
DEFINITION ribosomal S6 kinase [Homo sapiens].
ACCESSION CAA59427
VERSION CAA59427.1
DBSOURCE embl accession X85106.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Zhao,Y., Bjorbaek,C., Weremowicz,S., Morton,C.C. and Moller,D.E.
TITLE RSK3 encodes a novel pp90rsk isoform with a unique N-terminal
sequence: growth factor-stimulated kinase function and nuclear
translocation
JOURNAL Mol. Cell. Biol. 15 (8), 4353-4363 (1995)
PUBMED 7623830
REFERENCE 2 (residues 1 to 733)
AUTHORS Zhao,Y.
TITLE Direct Submission
JOURNAL Submitted (02-MAR-1995) Y. Zhao, Beth Israel Hospital/Harvard
Med.School, Div. of Endocrinology and Metabolism, 330 Brookline
Ave., Boston, MA 02215, USA
FEATURES Location/Qualifiers
source 1..733
/organism="Homo sapiens"
/db_xref="taxon:9606"
Protein 1..733
/product="ribosomal S6 kinase"
Region 63..379
/region_name="STKc_RSK_N"
/note="N-terminal catalytic domain of the Serine/Threonine
Kinase, 90 kDa ribosomal protein S6 kinase; cd05582"
/db_xref="CDD:270734"
Site order(65..69,73,89,91,122,138..139,141,145,147,184,186,
188..189,191,201..202,205,219..224,251,257,260)
/site_type="active"
/db_xref="CDD:270734"
Site order(65..69,73,89,91,122,139..141,145,184,186,188..189,
191,201..202)
/site_type="other"
/note="ATP binding site [chemical binding]"
/db_xref="CDD:270734"
Site order(69,145,147,184,186,188,205,219..224,251,257,260)
/site_type="other"
/note="polypeptide substrate binding site [polypeptide
binding]"
/db_xref="CDD:270734"
Site order(201..212,214..224)
/site_type="other"
/note="activation loop (A-loop)"
/db_xref="CDD:270734"
Site 360
/site_type="other"
/note="turn motif phosphorylation site [posttranslational
modification]"
/db_xref="CDD:270734"
Site 373..378
/site_type="other"
/note="hydrophobic motif (HM)"
/db_xref="CDD:270734"
Region 411..703
/region_name="STKc_RSK3_C"
/note="C-terminal catalytic domain of the Serine/Threonine
Kinase, Ribosomal S6 kinase 3 (also called Ribosomal
protein S6 kinase alpha-2 or 90kDa ribosomal protein S6
kinase 2); cd14178"
/db_xref="CDD:271080"
Site order(421..425,429,442,444,470,486..489,493,495,531..532,
534,536..537,539,553..554,557,572..576,578)
/site_type="active"
/db_xref="CDD:271080"
Site order(421..424,429,442,444,470,486..489,493,536..537,539,
553..554)
/site_type="other"
/note="ATP binding site [chemical binding]"
/db_xref="CDD:271080"
Site order(425,493,495,531..532,534,536,557,572..576,578)
/site_type="other"
/note="polypeptide substrate binding site [polypeptide
binding]"
/db_xref="CDD:271080"
Site 553..576
/site_type="other"
/note="activation loop (A-loop)"
/db_xref="CDD:271080"
CDS 1..733
/gene="pp90RSK3"
/coded_by="X85106.1:175..2376"
/db_xref="GOA:Q15349"
/db_xref="HGNC:HGNC:10431"
/db_xref="InterPro:IPR000719"
/db_xref="InterPro:IPR000961"
/db_xref="InterPro:IPR002290"
/db_xref="InterPro:IPR008271"
/db_xref="InterPro:IPR011009"
/db_xref="InterPro:IPR016239"
/db_xref="InterPro:IPR017441"
/db_xref="InterPro:IPR017442"
/db_xref="InterPro:IPR017892"
/db_xref="UniProtKB/Swiss-Prot:Q15349"
ORIGIN
1 mdlsmkkfav rrffsvylrr ksrsksssls rleeegvvke idishhvkeg fekadpsqfe
61 llkvlgqgsy gkvflvrkvk gsdagqlyam kvlkkatlkv rdrvrskmer dilaevnhpf
121 ivklhyafqt egklylildf lrggdlftrl skevmfteed vkfylaelal aldhlhslgi
181 iyrdlkpeni lldeeghiki tdfglskeai dhdkraysfc gtieymapev vnrrghtqsa
241 dwwsfgvlmf emltgslpfq gkdrketmal ilkaklgmpq flsgeaqsll ralfkrnpcn
301 rlgagidgve eikrhpffvt idwntlyrke ikppfkpalg rpedtfhfdp eftartptds
361 pgvppsanah hlfrgfsfva ssliqepsqq dlhkvpvhpi vqqlhgnnih ftdgyeiked
421 igvgsysvck rcvhkatdte yavkiidksk rdpseeieil lrygqhpnii tlkdvyddgk
481 fvylvmelmr ggelldrilr qryfsereas dvlctitktm dylhsqgvvh rdlkpsnily
541 rdesgspesi rvcdfgfakq lragngllmt pcytanfvap evlkrqgyda acdiwslgil
601 lytmlagftp fangpddtpe eilarigsgk yalsggnwds isdaakdvvs kmlhvdphqr
661 ltamqvlkhp wvvnreylsp nqlsrqdvhl vkgamaatyf alnrtpqapr lepvlssnla
721 qrrgmkrlts trl
//