Signal peptide peptidase 3 [Homo sapiens]

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N-terminome analyses underscore the prevalence of SPPL3-mediated intramembrane proteolysis among Golgi-resident enzymes and its role in Golgi enzyme secretion. [Cell Mol Life Sci. 2022]
N-terminome analyses underscore the prevalence of SPPL3-mediated intramembrane proteolysis among Golgi-resident enzymes and its role in Golgi enzyme secretion.
Hobohm L, Koudelka T, Bahr FH, Truberg J, Kapell S, Schacht SS, Meisinger D, Mengel M, Jochimsen A, Hofmann A, et al. Cell Mol Life Sci. 2022 Mar 13; 79(3):185. Epub 2022 Mar 13.
SPPL3-dependent downregulation of the synthesis of (neo)lacto-series glycosphingolipid is required for the staining of cell surface CD59. [Biochem Biophys Res Commun. 2021]
SPPL3-dependent downregulation of the synthesis of (neo)lacto-series glycosphingolipid is required for the staining of cell surface CD59.
Kawaguchi K, Yamamoto-Hino M, Goto S. Biochem Biophys Res Commun. 2021 Sep 24; 571:81-87. Epub 2021 Jul 23.
The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses. [Immunity. 2021]
The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses.
Jongsma MLM, de Waard AA, Raaben M, Zhang T, Cabukusta B, Platzer R, Blomen VA, Xagara A, Verkerk T, Bliss S, et al. Immunity. 2021 Jan 12; 54(1):132-150.e9. Epub 2020 Dec 2.

RefSeq protein isoforms
See 5 reference sequence protein isoforms for the SPPL3 gene.

Nucleotide
Nucleotide sequence from coding region
PubMed
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Transcript/Protein Information [PANTHER Classification System]
Transcript/Protein Information
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reagents [ExactAntigen/Labome]
reagents
ExactAntigen/Labome

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Protein