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RecName: Full=Ribonuclease HII; Short=RNase HII

UniProtKB/Swiss-Prot: A0LV66.1

Identical Proteins FASTA Graphics 

LOCUS       RNH2_ACIC1               307 aa            linear   BCT 27-NOV-2024
DEFINITION  RecName: Full=Ribonuclease HII; Short=RNase HII.
ACCESSION   A0LV66
VERSION     A0LV66.1
DBSOURCE    UniProtKB: locus RNH2_ACIC1, accession A0LV66;
            class: standard.
            created: May 20, 2008.
            sequence updated: Dec 12, 2006.
            annotation updated: Nov 27, 2024.
            xrefs: CP000481.1, ABK53326.1
            xrefs (non-sequence databases): AlphaFoldDB:A0LV66, SMR:A0LV66,
            STRING:351607.Acel_1554, KEGG:ace:Acel_1554, eggNOG:COG0164,
            HOGENOM:CLU_036532_1_0_11, InParanoid:A0LV66, OrthoDB:9803420at2,
            Proteomes:UP000008221, GO:0005737, GO:0032299, GO:0030145,
            GO:0003723, GO:0004523, GO:0043137, GO:0006298, CDD:cd07182,
            FunFam:3.30.420.10:FF:000113, Gene3D:3.30.420.10, HAMAP:MF_00052_B,
            InterPro:IPR022898, InterPro:IPR001352, InterPro:IPR024567,
            InterPro:IPR012337, InterPro:IPR036397, PANTHER:PTHR10954,
            PANTHER:PTHR10954:SF18, Pfam:PF01351, SUPFAM:SSF53098,
            PROSITE:PS51975
KEYWORDS    Cytoplasm; Endonuclease; Hydrolase; Manganese; Metal-binding;
            Nuclease; Reference proteome.
SOURCE      Acidothermus cellulolyticus 11B
  ORGANISM  Acidothermus cellulolyticus 11B
            Bacteria; Bacillati; Actinomycetota; Actinomycetes; Acidothermales;
            Acidothermaceae; Acidothermus.
REFERENCE   1  (residues 1 to 307)
  AUTHORS   Barabote,R.D., Xie,G., Leu,D.H., Normand,P., Necsulea,A.,
            Daubin,V., Medigue,C., Adney,W.S., Xu,X.C., Lapidus,A.,
            Parales,R.E., Detter,C., Pujic,P., Bruce,D., Lavire,C.,
            Challacombe,J.F., Brettin,T.S. and Berry,A.M.
  TITLE     Complete genome of the cellulolytic thermophile Acidothermus
            cellulolyticus 11B provides insights into its ecophysiological and
            evolutionary adaptations
  JOURNAL   Genome Res 19 (6), 1033-1043 (2009)
   PUBMED   19270083
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].;
            STRAIN=ATCC 43068 / DSM 8971 / 11B
COMMENT     [FUNCTION] Endonuclease that specifically degrades the RNA of
            RNA-DNA hybrids. {ECO:0000255|HAMAP-Rule:MF_00052}.
            [CATALYTIC ACTIVITY] Reaction=Endonucleolytic cleavage to
            5'-phosphomonoester.; EC=3.1.26.4;
            Evidence={ECO:0000255|HAMAP-Rule:MF_00052}.
            [COFACTOR] Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
            Evidence={ECO:0000255|HAMAP-Rule:MF_00052}; Name=Mg(2+);
            Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|HAMAP-Rule:MF_00052};
            Note=Manganese or magnesium. Binds 1 divalent metal ion per monomer
            in the absence of substrate. May bind a second metal ion after
            substrate binding. {ECO:0000255|HAMAP-Rule:MF_00052}.
            [SUBCELLULAR LOCATION] Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00052}.
            [SIMILARITY] Belongs to the RNase HII family.
            {ECO:0000255|HAMAP-Rule:MF_00052}.
FEATURES             Location/Qualifiers
     source          1..307
                     /organism="Acidothermus cellulolyticus 11B"
                     /db_xref="taxon:351607"
     gene            1..307
                     /gene="rnhB"
                     /locus_tag="Acel_1554"
     Protein         1..307
                     /product="Ribonuclease HII"
                     /EC_number="3.1.26.4"
                     /note="RNase HII"
                     /UniProtKB_evidence="Inferred from homology"
     Region          1..307
                     /region_name="Mature chain"
                     /note="Ribonuclease HII. /id=PRO_0000334852."
     Region          27..226
                     /region_name="rnhB"
                     /note="ribonuclease HII; Validated; PRK00015"
                     /db_xref="CDD:234574"
     Region          44..235
                     /region_name="Domain"
                     /note="RNase H type-2.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01319."
     Site            order(50..55,83,118..120,144..146,159..160,162,176,
                     197..199,201..203,223)
                     /site_type="other"
                     /note="RNA/DNA hybrid binding site [nucleotide binding]"
                     /db_xref="CDD:260003"
     Region          241..307
                     /region_name="Region of interest in the sequence"
                     /note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
ORIGIN      
        1 mgasttarlg parvrserrs caaerhrlvd lyryerrlar lglepvagvd eagrgacagp
       61 lvvaavilgs drrnriagla dskqltpaar esiyneiisr alawsvvvip ssevdelgvh
      121 aanitgmrra vaglavrpay vltdgfsiag lnapglavck gdeavaciaa asvvakvtrd
      181 rlmvelhekf pmyefathkg yvtaghraal arhgpcpehr rsfvtvrrag grmelritel
      241 adsddspgfa sgpaeavpgp agsagaasaa arpaaagpag rlvdqnraad lrdngdvsrp
      301 aelleip
//
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