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RecName: Full=Epithelial-stromal interaction protein 1

UniProtKB/Swiss-Prot: Q5BK43.1

Identical Proteins FASTA Graphics 

LOCUS       ESIP1_RAT                314 aa            linear   ROD 29-MAY-2024
DEFINITION  RecName: Full=Epithelial-stromal interaction protein 1.
ACCESSION   Q5BK43
VERSION     Q5BK43.1
DBSOURCE    UniProtKB: locus ESIP1_RAT, accession Q5BK43;
            class: standard.
            created: Jan 15, 2008.
            sequence updated: Apr 12, 2005.
            annotation updated: May 29, 2024.
            xrefs: BC091212.1, AAH91212.1, NP_001037722.1
            xrefs (non-sequence databases): AlphaFoldDB:Q5BK43, SMR:Q5BK43,
            STRING:10116.ENSRNOP00000012632, PhosphoSitePlus:Q5BK43,
            PaxDb:10116-ENSRNOP00000012632, Ensembl:ENSRNOT00000012632.6,
            Ensembl:ENSRNOP00000012632.4, Ensembl:ENSRNOG00000009471.6,
            Ensembl:ENSRNOT00055025566, Ensembl:ENSRNOP00055020853,
            Ensembl:ENSRNOG00055014953, Ensembl:ENSRNOT00060034005,
            Ensembl:ENSRNOP00060027847, Ensembl:ENSRNOG00060019674,
            Ensembl:ENSRNOT00065014331, Ensembl:ENSRNOP00065010727,
            Ensembl:ENSRNOG00065008973, GeneID:498547, KEGG:rno:498547,
            UCSC:RGD:1563207, AGR:RGD:1563207, CTD:94240, RGD:1563207,
            eggNOG:ENOG502RZCM, GeneTree:ENSGT00390000013820,
            HOGENOM:CLU_058937_1_0_1, InParanoid:Q5BK43, OMA:MNSANSW,
            OrthoDB:4273805at2759, PhylomeDB:Q5BK43, TreeFam:TF335788,
            Reactome:R-RNO-9696273, PRO:PR:Q5BK43, Proteomes:UP000002494,
            Bgee:ENSRNOG00000009471, InterPro:IPR026185, PANTHER:PTHR22529,
            PANTHER:PTHR22529:SF1
KEYWORDS    Coiled coil; Reference proteome.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 314)
  AUTHORS   Gerhard,D.S., Wagner,L., Feingold,E.A., Shenmen,C.M., Grouse,L.H.,
            Schuler,G., Klein,S.L., Old,S., Rasooly,R., Good,P., Guyer,M.,
            Peck,A.M., Derge,J.G., Lipman,D., Collins,F.S., Jang,W., Sherry,S.,
            Feolo,M., Misquitta,L., Lee,E., Rotmistrovsky,K., Greenhut,S.F.,
            Schaefer,C.F., Buetow,K., Bonner,T.I., Haussler,D., Kent,J.,
            Kiekhaus,M., Furey,T., Brent,M., Prange,C., Schreiber,K.,
            Shapiro,N., Bhat,N.K., Hopkins,R.F., Hsie,F., Driscoll,T.,
            Soares,M.B., Casavant,T.L., Scheetz,T.E., Brown-stein,M.J.,
            Usdin,T.B., Toshiyuki,S., Carninci,P., Piao,Y., Dudekula,D.B.,
            Ko,M.S., Kawakami,K., Suzuki,Y., Sugano,S., Gruber,C.E.,
            Smith,M.R., Simmons,B., Moore,T., Waterman,R., Johnson,S.L.,
            Ruan,Y., Wei,C.L., Mathavan,S., Gunaratne,P.H., Wu,J., Garcia,A.M.,
            Hulyk,S.W., Fuh,E., Yuan,Y., Sneed,A., Kowis,C., Hodgson,A.,
            Muzny,D.M., McPherson,J., Gibbs,R.A., Fahey,J., Helton,E.,
            Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M.,
            Madari,A., Young,A.C., Wetherby,K.D., Granite,S.J., Kwong,P.N.,
            Brinkley,C.P., Pearson,R.L., Bouffard,G.G., Blakesly,R.W.,
            Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J.,
            Myers,R.M., Butterfield,Y.S., Griffith,M., Griffith,O.L.,
            Krzywinski,M.I., Liao,N., Morin,R., Palmquist,D., Petrescu,A.S.,
            Skalska,U., Smailus,D.E., Stott,J.M., Schnerch,A., Schein,J.E.,
            Jones,S.J., Holt,R.A., Baross,A., Marra,M.A., Clifton,S.,
            Makowski,K.A., Bosak,S. and Malek,J.
  CONSRTM   MGC Project Team
  TITLE     The status, quality, and expansion of the NIH full-length cDNA
            project: the Mammalian Gene Collection (MGC)
  JOURNAL   Genome Res 14 (10B), 2121-2127 (2004)
   PUBMED   15489334
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].;
            TISSUE=Thymus
            Erratum:[Genome Res. 2006 Jun;16(6):804. Morrin, Ryan [corrected to
            Morin, Ryan]]
COMMENT     [FUNCTION] Plays a role in M1 macrophage polarization and is
            required for the proper regulation of gene expression during M1
            versus M2 macrophage differentiation (By similarity). Might play a
            role in RELA/p65 and STAT1 phosphorylation and nuclear localization
            upon activation of macrophages (By similarity).
            {ECO:0000250|UniProtKB:Q8VDI1}.
FEATURES             Location/Qualifiers
     source          1..314
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
     gene            1..314
                     /gene="Epsti1"
     Protein         1..314
                     /product="Epithelial-stromal interaction protein 1"
                     /UniProtKB_evidence="Evidence at transcript level"
     Region          1..314
                     /region_name="Mature chain"
                     /note="Epithelial-stromal interaction protein 1.
                     /id=PRO_0000314036."
     Region          1..72
                     /region_name="Region of interest in the sequence"
                     /note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
     Region          57..72
                     /region_name="Compositionally biased region"
                     /note="Polar residues.
                     /evidence=ECO:0000256|SAM:MobiDB-lite."
     Region          71..180
                     /region_name="Coiled-coil region"
                     /note="/evidence=ECO:0000255."
     Region          <113..177
                     /region_name="ATP-synt_Fo_b"
                     /note="F-type ATP synthase, membrane subunit b; cl21478"
                     /db_xref="CDD:473877"
     Region          200..219
                     /region_name="Region of interest in the sequence"
                     /note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
     Region          225..267
                     /region_name="Region of interest in the sequence"
                     /note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
     Region          228..267
                     /region_name="Compositionally biased region"
                     /note="Basic and acidic residues.
                     /evidence=ECO:0000256|SAM:MobiDB-lite."
     Region          292..314
                     /region_name="Region of interest in the sequence"
                     /note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
     Region          293..314
                     /region_name="Compositionally biased region"
                     /note="Polar residues.
                     /evidence=ECO:0000256|SAM:MobiDB-lite."
ORIGIN      
        1 myprsrvvgp glgtssssrd hagagqhgel dlqqnqrqnl evaepkgpkl erqghgdqrs
       61 tgtytliapn etrrqkiqri aeqeladler wkqqnkakpv hlvpqrlggs qseaevrqkq
      121 qlqqmrskyq qklkrdeair irkdaeeael qrmkaiqrek snklekkkql qedirratlr
      181 ehhqsktael lsrldtdrtn rsacniappa aqssrwklpv llrdpsrags qahkdspqke
      241 dnqklqktrd ghqknkllet kgqhqeeera qihqaehwrv nnafldrlqg ksqpggveqs
      301 ggcwnmnstd gwgi
//
Feature
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