LOCUS ESIP1_RAT 314 aa linear ROD 29-MAY-2024
DEFINITION RecName: Full=Epithelial-stromal interaction protein 1.
ACCESSION Q5BK43
VERSION Q5BK43.1
DBSOURCE UniProtKB: locus ESIP1_RAT, accession Q5BK43;
class: standard.
created: Jan 15, 2008.
sequence updated: Apr 12, 2005.
annotation updated: May 29, 2024.
xrefs: BC091212.1, AAH91212.1, NP_001037722.1
xrefs (non-sequence databases): AlphaFoldDB:Q5BK43, SMR:Q5BK43,
STRING:10116.ENSRNOP00000012632, PhosphoSitePlus:Q5BK43,
PaxDb:10116-ENSRNOP00000012632, Ensembl:ENSRNOT00000012632.6,
Ensembl:ENSRNOP00000012632.4, Ensembl:ENSRNOG00000009471.6,
Ensembl:ENSRNOT00055025566, Ensembl:ENSRNOP00055020853,
Ensembl:ENSRNOG00055014953, Ensembl:ENSRNOT00060034005,
Ensembl:ENSRNOP00060027847, Ensembl:ENSRNOG00060019674,
Ensembl:ENSRNOT00065014331, Ensembl:ENSRNOP00065010727,
Ensembl:ENSRNOG00065008973, GeneID:498547, KEGG:rno:498547,
UCSC:RGD:1563207, AGR:RGD:1563207, CTD:94240, RGD:1563207,
eggNOG:ENOG502RZCM, GeneTree:ENSGT00390000013820,
HOGENOM:CLU_058937_1_0_1, InParanoid:Q5BK43, OMA:MNSANSW,
OrthoDB:4273805at2759, PhylomeDB:Q5BK43, TreeFam:TF335788,
Reactome:R-RNO-9696273, PRO:PR:Q5BK43, Proteomes:UP000002494,
Bgee:ENSRNOG00000009471, InterPro:IPR026185, PANTHER:PTHR22529,
PANTHER:PTHR22529:SF1
KEYWORDS Coiled coil; Reference proteome.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (residues 1 to 314)
AUTHORS Gerhard,D.S., Wagner,L., Feingold,E.A., Shenmen,C.M., Grouse,L.H.,
Schuler,G., Klein,S.L., Old,S., Rasooly,R., Good,P., Guyer,M.,
Peck,A.M., Derge,J.G., Lipman,D., Collins,F.S., Jang,W., Sherry,S.,
Feolo,M., Misquitta,L., Lee,E., Rotmistrovsky,K., Greenhut,S.F.,
Schaefer,C.F., Buetow,K., Bonner,T.I., Haussler,D., Kent,J.,
Kiekhaus,M., Furey,T., Brent,M., Prange,C., Schreiber,K.,
Shapiro,N., Bhat,N.K., Hopkins,R.F., Hsie,F., Driscoll,T.,
Soares,M.B., Casavant,T.L., Scheetz,T.E., Brown-stein,M.J.,
Usdin,T.B., Toshiyuki,S., Carninci,P., Piao,Y., Dudekula,D.B.,
Ko,M.S., Kawakami,K., Suzuki,Y., Sugano,S., Gruber,C.E.,
Smith,M.R., Simmons,B., Moore,T., Waterman,R., Johnson,S.L.,
Ruan,Y., Wei,C.L., Mathavan,S., Gunaratne,P.H., Wu,J., Garcia,A.M.,
Hulyk,S.W., Fuh,E., Yuan,Y., Sneed,A., Kowis,C., Hodgson,A.,
Muzny,D.M., McPherson,J., Gibbs,R.A., Fahey,J., Helton,E.,
Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M.,
Madari,A., Young,A.C., Wetherby,K.D., Granite,S.J., Kwong,P.N.,
Brinkley,C.P., Pearson,R.L., Bouffard,G.G., Blakesly,R.W.,
Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J.,
Myers,R.M., Butterfield,Y.S., Griffith,M., Griffith,O.L.,
Krzywinski,M.I., Liao,N., Morin,R., Palmquist,D., Petrescu,A.S.,
Skalska,U., Smailus,D.E., Stott,J.M., Schnerch,A., Schein,J.E.,
Jones,S.J., Holt,R.A., Baross,A., Marra,M.A., Clifton,S.,
Makowski,K.A., Bosak,S. and Malek,J.
CONSRTM MGC Project Team
TITLE The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC)
JOURNAL Genome Res 14 (10B), 2121-2127 (2004)
PUBMED 15489334
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].;
TISSUE=Thymus
Erratum:[Genome Res. 2006 Jun;16(6):804. Morrin, Ryan [corrected to
Morin, Ryan]]
COMMENT [FUNCTION] Plays a role in M1 macrophage polarization and is
required for the proper regulation of gene expression during M1
versus M2 macrophage differentiation (By similarity). Might play a
role in RELA/p65 and STAT1 phosphorylation and nuclear localization
upon activation of macrophages (By similarity).
{ECO:0000250|UniProtKB:Q8VDI1}.
FEATURES Location/Qualifiers
source 1..314
/organism="Rattus norvegicus"
/db_xref="taxon:10116"
gene 1..314
/gene="Epsti1"
Protein 1..314
/product="Epithelial-stromal interaction protein 1"
/UniProtKB_evidence="Evidence at transcript level"
Region 1..314
/region_name="Mature chain"
/note="Epithelial-stromal interaction protein 1.
/id=PRO_0000314036."
Region 1..72
/region_name="Region of interest in the sequence"
/note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
Region 57..72
/region_name="Compositionally biased region"
/note="Polar residues.
/evidence=ECO:0000256|SAM:MobiDB-lite."
Region 71..180
/region_name="Coiled-coil region"
/note="/evidence=ECO:0000255."
Region <113..177
/region_name="ATP-synt_Fo_b"
/note="F-type ATP synthase, membrane subunit b; cl21478"
/db_xref="CDD:473877"
Region 200..219
/region_name="Region of interest in the sequence"
/note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
Region 225..267
/region_name="Region of interest in the sequence"
/note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
Region 228..267
/region_name="Compositionally biased region"
/note="Basic and acidic residues.
/evidence=ECO:0000256|SAM:MobiDB-lite."
Region 292..314
/region_name="Region of interest in the sequence"
/note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
Region 293..314
/region_name="Compositionally biased region"
/note="Polar residues.
/evidence=ECO:0000256|SAM:MobiDB-lite."
ORIGIN
1 myprsrvvgp glgtssssrd hagagqhgel dlqqnqrqnl evaepkgpkl erqghgdqrs
61 tgtytliapn etrrqkiqri aeqeladler wkqqnkakpv hlvpqrlggs qseaevrqkq
121 qlqqmrskyq qklkrdeair irkdaeeael qrmkaiqrek snklekkkql qedirratlr
181 ehhqsktael lsrldtdrtn rsacniappa aqssrwklpv llrdpsrags qahkdspqke
241 dnqklqktrd ghqknkllet kgqhqeeera qihqaehwrv nnafldrlqg ksqpggveqs
301 ggcwnmnstd gwgi
//