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2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Micrococcus luteus]

NCBI Reference Sequence: WP_012750740.1

Identical Proteins FASTA Graphics 

LOCUS       WP_012750740             433 aa            linear   BCT 29-APR-2021
DEFINITION  2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Micrococcus
            luteus].
ACCESSION   WP_012750740
VERSION     WP_012750740.1
KEYWORDS    RefSeq.
SOURCE      Micrococcus luteus
  ORGANISM  Micrococcus luteus
            Bacteria; Bacillati; Actinomycetota; Actinomycetes; Micrococcales;
            Micrococcaceae; Micrococcus.
REFERENCE   1  (residues 1 to 433)
  AUTHORS   Narayanasamy,P., Eoh,H., Brennan,P.J. and Crick,D.C.
  TITLE     Synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate
            and kinetic studies of Mycobacterium tuberculosis IspF
  JOURNAL   Chem Biol 17 (2), 117-122 (2010)
   PUBMED   20189102
REFERENCE   2  (residues 1 to 433)
  AUTHORS   Herz,S., Wungsintaweekul,J., Schuhr,C.A., Hecht,S., Luttgen,H.,
            Sagner,S., Fellermeier,M., Eisenreich,W., Zenk,M.H., Bacher,A. and
            Rohdich,F.
  TITLE     Biosynthesis of terpenoids: YgbB protein converts
            4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate to
            2C-methyl-D-erythritol 2,4-cyclodiphosphate
  JOURNAL   Proc Natl Acad Sci U S A 97 (6), 2486-2490 (2000)
   PUBMED   10694574
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR00151.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..433
                     /organism="Micrococcus luteus"
                     /db_xref="taxon:1270"
     gene            1..433
                     /gene="ispF"
     Protein         1..433
                     /product="2-C-methyl-D-erythritol 2,4-cyclodiphosphate
                     synthase"
                     /EC_number="4.6.1.12"
                     /GO_function="GO:0008685 - 2-C-methyl-D-erythritol
                     2,4-cyclodiphosphate synthase activity [Evidence IEA]"
                     /GO_process="GO:0019288 - isopentenyl diphosphate
                     biosynthetic process, methylerythritol 4-phosphate pathway
                     [Evidence IEA]"
                     /calculated_mol_wt=43060
     Region          1..430
                     /region_name="ispDF"
                     /note="bifunctional 2-C-methyl-D-erythritol 4-phosphate
                     cytidylyltransferase/2-C-methyl-D-erythritol
                     2,4-cyclodiphosphate synthase protein; Provisional;
                     PRK09382"
                     /db_xref="CDD:236492"
ORIGIN      
        1 mptalviaaa gagtrlgagl pkalapladg rtllrhcles vaaaraagla ldavvvltpp
       61 tevdagrvaa evdagprldv pvhcvpggae radsvragla aasraladfa pagaprrvlv
      121 hdaaraltpp svfgavtaal etgavaavpg lpltdtvkqv tpgrggvdvv aatparaglr
      181 aiqtpqgfdl dtllaaheav radptldaaa ltddamvmea aghevvvvpg dpaafkvtap
      241 gdldlarlel arrapqeeap mdqparpaaa paplprvgig tdvhawaped aprplwlggi
      301 hwpgergvaa tsdgdvvaha acnallsaag lgdlgavfgv drpemadasg admlrevlrl
      361 lteaglavgn vavqvvaprp kvgtrraeme aalsaalgga pvsvsaattd rlgfigrreg
      421 lvgiatalvv paa
//
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Protein clusters for WP_012750740.1

More about the gene ispF

  • ispF gene
    Also Known As: DQN81_RS06905, NCTC2665...

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