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PDB: 3VRR_A
Identical Proteins FASTA Graphics
LOCUS 3VRR_A 331 aa linear PRI 31-OCT-2024 DEFINITION Chain A, Signal transduction protein CBL-C. ACCESSION 3VRR_A VERSION 3VRR_A DBSOURCE pdb: molecule 3VRR, chain A, release Oct 30, 2024; deposition: Apr 13, 2012; class: PROTEIN BINDING/TRANSFERASE; source: Mmdb_id: 108064, Pdb_id 1: 3VRR; Exp. method: X-ray Diffraction. KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 331) AUTHORS Takeshita,K., Tezuka,T., Isozaki,Y., Yamashita,E., Suzuki,M., Kim,M., Yamanashi,Y., Yamamoto,T. and Nakagawa,A. TITLE Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c JOURNAL J Biochem 152 (5), 487-495 (2012) PUBMED 22888118 REFERENCE 2 (residues 1 to 331) AUTHORS Takeshita,K., Tezuka,T., Isozaki,Y., Yamashita,E., Suzuki,M., Yamanashi,Y., Yamamoto,T. and Nakagawa,A. TITLE Direct Submission JOURNAL Submitted (13-APR-2012) COMMENT Crystal structure of the tyrosine kinase binding domain of Cbl-c (PL mutant) in complex with phospho-EGFR peptide. FEATURES Location/Qualifiers source 1..331 /organism="Homo sapiens" /db_xref="taxon:9606" Region 1..154 /region_name="Domain 1" /note="NCBI Domains" Region 21..153 /region_name="Cbl_N" /note="CBL proto-oncogene N-terminal domain 1; pfam02262" /db_xref="CDD:426685" SecStr 24..40 /sec_str_type="helix" /note="helix 1" SecStr 53..70 /sec_str_type="helix" /note="helix 2" SecStr 84..105 /sec_str_type="helix" /note="helix 3" SecStr 124..146 /sec_str_type="helix" /note="helix 4" Region 155..245 /region_name="Domain 2" /note="NCBI Domains" Region 157..240 /region_name="Cbl_N2" /note="CBL proto-oncogene N-terminus, EF hand-like domain; pfam02761" /db_xref="CDD:460681" SecStr 162..171 /sec_str_type="helix" /note="helix 5" SecStr 176..180 /sec_str_type="sheet" /note="strand 1" SecStr 181..188 /sec_str_type="helix" /note="helix 6" SecStr 197..206 /sec_str_type="helix" /note="helix 7" Het join(bond(207),bond(209),bond(211),bond(213),bond(218), bond(218)) /heterogen="(CA,2379)" SecStr 212..216 /sec_str_type="sheet" /note="strand 2" SecStr 217..226 /sec_str_type="helix" /note="helix 8" SecStr 232..239 /sec_str_type="helix" /note="helix 9" Region 234..330 /region_name="SH2_Cbl-b_TKB" /note="Src homology 2 (SH2) domain found in the Cbl-b TKB domain; cd09920" /db_xref="CDD:198176" Region 246..331 /region_name="Domain 3" /note="NCBI Domains" Site order(252,272,274..277,282,294,296) /site_type="other" /note="phosphotyrosine binding pocket [polypeptide binding]" /db_xref="CDD:198176" SecStr 252..259 /sec_str_type="helix" /note="helix 10" SecStr 267..273 /sec_str_type="sheet" /note="strand 3" SecStr 281..288 /sec_str_type="sheet" /note="strand 4" SecStr 290..296 /sec_str_type="sheet" /note="strand 5" Site order(297..300,313..315) /site_type="other" /note="hydrophobic binding pocket [polypeptide binding]" /db_xref="CDD:198176" SecStr 302..312 /sec_str_type="helix" /note="helix 11" SecStr 316..319 /sec_str_type="sheet" /note="strand 6" ORIGIN 1 gplgspefma lavapwgrqw eearalgrav rmlqrleeqc vdprlsvspp slrdllprta 61 qllrevahsr raaggggpgg pggsgdflli ylanleaksr qvaallpprg rrsandelfr 121 agsrlrrqla klaiifshmh aelhalfpgg kycghmyqlt kapahtfwre scgarcvlpw 181 aefesllgtc hpvepgctal alrttidltc sghvsifefd vftrlfqpwp tllknwqlla 241 vnhpgymafl tydevqerlq acrdkpgsyi frlsctrlgq waigyvssdg silqtipank 301 plsqvllegq kdgfylypdg kthnpdltel g //
Whole sequence Selected region from: to:
Conserved Domains
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