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Chain A, Signal transduction protein CBL-C

PDB: 3VRR_A

Identical Proteins FASTA Graphics 

LOCUS       3VRR_A                   331 aa            linear   PRI 31-OCT-2024
DEFINITION  Chain A, Signal transduction protein CBL-C.
ACCESSION   3VRR_A
VERSION     3VRR_A
DBSOURCE    pdb: molecule 3VRR, chain A, release Oct 30, 2024;
            deposition: Apr 13, 2012;
            class: PROTEIN BINDING/TRANSFERASE;
            source: Mmdb_id: 108064, Pdb_id 1: 3VRR;
            Exp. method: X-ray Diffraction.
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 331)
  AUTHORS   Takeshita,K., Tezuka,T., Isozaki,Y., Yamashita,E., Suzuki,M.,
            Kim,M., Yamanashi,Y., Yamamoto,T. and Nakagawa,A.
  TITLE     Structural flexibility regulates phosphopeptide-binding activity of
            the tyrosine kinase binding domain of Cbl-c
  JOURNAL   J Biochem 152 (5), 487-495 (2012)
   PUBMED   22888118
REFERENCE   2  (residues 1 to 331)
  AUTHORS   Takeshita,K., Tezuka,T., Isozaki,Y., Yamashita,E., Suzuki,M.,
            Yamanashi,Y., Yamamoto,T. and Nakagawa,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-APR-2012)
COMMENT     Crystal structure of the tyrosine kinase binding domain of Cbl-c
            (PL mutant) in complex with phospho-EGFR peptide.
FEATURES             Location/Qualifiers
     source          1..331
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
     Region          1..154
                     /region_name="Domain 1"
                     /note="NCBI Domains"
     Region          21..153
                     /region_name="Cbl_N"
                     /note="CBL proto-oncogene N-terminal domain 1; pfam02262"
                     /db_xref="CDD:426685"
     SecStr          24..40
                     /sec_str_type="helix"
                     /note="helix 1"
     SecStr          53..70
                     /sec_str_type="helix"
                     /note="helix 2"
     SecStr          84..105
                     /sec_str_type="helix"
                     /note="helix 3"
     SecStr          124..146
                     /sec_str_type="helix"
                     /note="helix 4"
     Region          155..245
                     /region_name="Domain 2"
                     /note="NCBI Domains"
     Region          157..240
                     /region_name="Cbl_N2"
                     /note="CBL proto-oncogene N-terminus, EF hand-like domain;
                     pfam02761"
                     /db_xref="CDD:460681"
     SecStr          162..171
                     /sec_str_type="helix"
                     /note="helix 5"
     SecStr          176..180
                     /sec_str_type="sheet"
                     /note="strand 1"
     SecStr          181..188
                     /sec_str_type="helix"
                     /note="helix 6"
     SecStr          197..206
                     /sec_str_type="helix"
                     /note="helix 7"
     Het             join(bond(207),bond(209),bond(211),bond(213),bond(218),
                     bond(218))
                     /heterogen="(CA,2379)"
     SecStr          212..216
                     /sec_str_type="sheet"
                     /note="strand 2"
     SecStr          217..226
                     /sec_str_type="helix"
                     /note="helix 8"
     SecStr          232..239
                     /sec_str_type="helix"
                     /note="helix 9"
     Region          234..330
                     /region_name="SH2_Cbl-b_TKB"
                     /note="Src homology 2 (SH2) domain found in the Cbl-b TKB
                     domain; cd09920"
                     /db_xref="CDD:198176"
     Region          246..331
                     /region_name="Domain 3"
                     /note="NCBI Domains"
     Site            order(252,272,274..277,282,294,296)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198176"
     SecStr          252..259
                     /sec_str_type="helix"
                     /note="helix 10"
     SecStr          267..273
                     /sec_str_type="sheet"
                     /note="strand 3"
     SecStr          281..288
                     /sec_str_type="sheet"
                     /note="strand 4"
     SecStr          290..296
                     /sec_str_type="sheet"
                     /note="strand 5"
     Site            order(297..300,313..315)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198176"
     SecStr          302..312
                     /sec_str_type="helix"
                     /note="helix 11"
     SecStr          316..319
                     /sec_str_type="sheet"
                     /note="strand 6"
ORIGIN      
        1 gplgspefma lavapwgrqw eearalgrav rmlqrleeqc vdprlsvspp slrdllprta
       61 qllrevahsr raaggggpgg pggsgdflli ylanleaksr qvaallpprg rrsandelfr
      121 agsrlrrqla klaiifshmh aelhalfpgg kycghmyqlt kapahtfwre scgarcvlpw
      181 aefesllgtc hpvepgctal alrttidltc sghvsifefd vftrlfqpwp tllknwqlla
      241 vnhpgymafl tydevqerlq acrdkpgsyi frlsctrlgq waigyvssdg silqtipank
      301 plsqvllegq kdgfylypdg kthnpdltel g
//
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