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RecName: Full=Olfactory receptor 6M1; AltName: Full=Olfactory receptor OR11-271

UniProtKB/Swiss-Prot: Q8NGM8.1

Identical Proteins FASTA Graphics 

LOCUS       OR6M1_HUMAN              313 aa            linear   PRI 27-NOV-2024
DEFINITION  RecName: Full=Olfactory receptor 6M1; AltName: Full=Olfactory
            receptor OR11-271.
ACCESSION   Q8NGM8
VERSION     Q8NGM8.1
DBSOURCE    UniProtKB: locus OR6M1_HUMAN, accession Q8NGM8;
            class: standard.
            extra accessions:B2RNK0,Q6IEW9,Q96R37
            created: Oct 10, 2003.
            sequence updated: Oct 1, 2002.
            annotation updated: Nov 27, 2024.
            xrefs: AB065762.1, BAC05982.1, CH471065.1, EAW67556.1, BC136929.1,
            AAI36930.1, BC136931.1, AAI36932.1, AF399606.1, AAK95091.1,
            BK004493.1, DAA04891.1, NP_001005325.1
            xrefs (non-sequence databases): CCDS:CCDS31696.1,
            AlphaFoldDB:Q8NGM8, SMR:Q8NGM8, BioGRID:133477, IntAct:Q8NGM8,
            STRING:9606.ENSP00000311038, GlyCosmos:Q8NGM8, GlyGen:Q8NGM8,
            iPTMnet:Q8NGM8, PhosphoSitePlus:Q8NGM8, BioMuta:OR6M1,
            MassIVE:Q8NGM8, PaxDb:9606-ENSP00000311038, Antibodypedia:63993,
            DNASU:390261, Ensembl:ENST00000309154.3, Ensembl:ENSP00000311038.2,
            Ensembl:ENSG00000196099.5, GeneID:390261, KEGG:hsa:390261,
            MANE-Select:ENST00000309154.3, UCSC:uc010rzz.3, AGR:HGNC:14711,
            CTD:390261, GeneCards:OR6M1, HGNC:14711, HPA:ENSG00000196099,
            neXtProt:NX_Q8NGM8, PharmGKB:PA32596,
            VEuPathDB:HostDB:ENSG00000196099, eggNOG:ENOG502SFXX,
            GeneTree:ENSGT01090000260086, HOGENOM:CLU_012526_1_1_1,
            InParanoid:Q8NGM8, OMA:MGNWSTV, OrthoDB:5401587at2759,
            PhylomeDB:Q8NGM8, TreeFam:TF336833, PathwayCommons:Q8NGM8,
            Reactome:R-HSA-9752946, BioGRID-ORCS:390261, GeneWiki:OR6M1,
            GenomeRNAi:390261, Pharos:Q8NGM8, PRO:PR:Q8NGM8,
            Proteomes:UP000005640, RNAct:Q8NGM8, Bgee:ENSG00000196099,
            ExpressionAtlas:Q8NGM8, GO:0005886, GO:0004930, GO:0004984,
            CDD:cd15912, FunFam:1.20.1070.10:FF:000010, Gene3D:1.20.1070.10,
            InterPro:IPR000276, InterPro:IPR017452, InterPro:IPR000725,
            InterPro:IPR047132, PANTHER:PTHR26454, PANTHER:PTHR26454:SF51,
            Pfam:PF00001, PRINTS:PR00237, PRINTS:PR00245, SUPFAM:SSF81321,
            PROSITE:PS00237, PROSITE:PS50262
KEYWORDS    Cell membrane; Disulfide bond; G-protein coupled receptor;
            Glycoprotein; Membrane; Olfaction; Receptor; Reference proteome;
            Sensory transduction; Transducer; Transmembrane; Transmembrane
            helix.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 313)
  AUTHORS   Suwa,M., Sato,T., Okouchi,I., Arita,M., Futami,K., Matsumoto,S.,
            Tsutsumi,S., Aburatani,H., Asai,K. and Akiyama,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (??-JUL-2001) to the EMBL/GenBank/DDBJ databases
  REMARK    NUCLEOTIDE SEQUENCE [GENOMIC DNA].
REFERENCE   2  (residues 1 to 313)
  AUTHORS   Mural,R.J., Istrail,S., Sutton,G.G., Florea,L., Halpern,A.L.,
            Mobarry,C.M., Lippert,R., Walenz,B., Shatkay,H., Dew,I.,
            Miller,J.R., Flanigan,M.J., Edwards,N.J., Bolanos,R., Fasulo,D.,
            Halldorsson,B.V., Hannenhalli,S., Turner,R., Yooseph,S., Lu,F.,
            Nusskern,D.R., Shue,B.C., Zheng,X.H., Zhong,F., Delcher,A.L.,
            Huson,D.H., Kravitz,S.A., Mouchard,L., Reinert,K., Remington,K.A.,
            Clark,A.G., Waterman,M.S., Eichler,E.E., Adams,M.D.,
            Hunkapiller,M.W., Myers,E.W. and Venter,J.C.
  TITLE     Direct Submission
  JOURNAL   Submitted (??-JUL-2005) to the EMBL/GenBank/DDBJ databases
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
REFERENCE   3  (residues 1 to 313)
  AUTHORS   Gerhard,D.S., Wagner,L., Feingold,E.A., Shenmen,C.M., Grouse,L.H.,
            Schuler,G., Klein,S.L., Old,S., Rasooly,R., Good,P., Guyer,M.,
            Peck,A.M., Derge,J.G., Lipman,D., Collins,F.S., Jang,W., Sherry,S.,
            Feolo,M., Misquitta,L., Lee,E., Rotmistrovsky,K., Greenhut,S.F.,
            Schaefer,C.F., Buetow,K., Bonner,T.I., Haussler,D., Kent,J.,
            Kiekhaus,M., Furey,T., Brent,M., Prange,C., Schreiber,K.,
            Shapiro,N., Bhat,N.K., Hopkins,R.F., Hsie,F., Driscoll,T.,
            Soares,M.B., Casavant,T.L., Scheetz,T.E., Brown-stein,M.J.,
            Usdin,T.B., Toshiyuki,S., Carninci,P., Piao,Y., Dudekula,D.B.,
            Ko,M.S., Kawakami,K., Suzuki,Y., Sugano,S., Gruber,C.E.,
            Smith,M.R., Simmons,B., Moore,T., Waterman,R., Johnson,S.L.,
            Ruan,Y., Wei,C.L., Mathavan,S., Gunaratne,P.H., Wu,J., Garcia,A.M.,
            Hulyk,S.W., Fuh,E., Yuan,Y., Sneed,A., Kowis,C., Hodgson,A.,
            Muzny,D.M., McPherson,J., Gibbs,R.A., Fahey,J., Helton,E.,
            Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M.,
            Madari,A., Young,A.C., Wetherby,K.D., Granite,S.J., Kwong,P.N.,
            Brinkley,C.P., Pearson,R.L., Bouffard,G.G., Blakesly,R.W.,
            Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J.,
            Myers,R.M., Butterfield,Y.S., Griffith,M., Griffith,O.L.,
            Krzywinski,M.I., Liao,N., Morin,R., Palmquist,D., Petrescu,A.S.,
            Skalska,U., Smailus,D.E., Stott,J.M., Schnerch,A., Schein,J.E.,
            Jones,S.J., Holt,R.A., Baross,A., Marra,M.A., Clifton,S.,
            Makowski,K.A., Bosak,S. and Malek,J.
  CONSRTM   MGC Project Team
  TITLE     The status, quality, and expansion of the NIH full-length cDNA
            project: the Mammalian Gene Collection (MGC)
  JOURNAL   Genome Res 14 (10B), 2121-2127 (2004)
   PUBMED   15489334
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
            Erratum:[Genome Res. 2006 Jun;16(6):804. Morrin, Ryan [corrected to
            Morin, Ryan]]
REFERENCE   4  (residues 1 to 313)
  AUTHORS   Fuchs,T., Malecova,B., Linhart,C., Sharan,R., Khen,M., Herwig,R.,
            Shmulevich,D., Elkon,R., Steinfath,M., O'Brien,J.K., Radelof,U.,
            Lehrach,H., Lancet,D. and Shamir,R.
  TITLE     DEFOG: a practical scheme for deciphering families of genes
  JOURNAL   Genomics 80 (3), 295-302 (2002)
   PUBMED   12213199
  REMARK    NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-281.
REFERENCE   5  (residues 1 to 313)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    IDENTIFICATION.
            Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   6  (residues 1 to 313)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101, 7205-7205 (2004)
  REMARK    ERRATUM OF PUBMED:14983052.
COMMENT     [FUNCTION] Odorant receptor. {ECO:0000305}.
            [SUBCELLULAR LOCATION] Cell membrane; Multi-pass membrane protein.
            [SIMILARITY] Belongs to the G-protein coupled receptor 1 family.
            {ECO:0000255|PROSITE-ProRule:PRU00521}.
            [WEB RESOURCE] Name=Human Olfactory Receptor Data Exploratorium
            (HORDE);
            URL='http://genome.weizmann.ac.il/horde/card/index/symbol:OR6M1'.
FEATURES             Location/Qualifiers
     source          1..313
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
     gene            1..313
                     /gene="OR6M1"
     Protein         1..313
                     /product="Olfactory receptor 6M1"
                     /note="Olfactory receptor OR11-271"
                     /UniProtKB_evidence="Evidence at transcript level"
     Region          1..313
                     /region_name="Mature chain"
                     /note="Olfactory receptor 6M1. /id=PRO_0000150632."
     Region          1..23
                     /region_name="Topological domain"
                     /note="Extracellular. /evidence=ECO:0000255."
     Site            3
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255."
     Region          23..291
                     /region_name="7tmA_OR6C-like"
                     /note="olfactory receptor subfamily 6C and related
                     proteins, member of the class A family of
                     seven-transmembrane G protein-coupled receptors; cd15912"
                     /db_xref="CDD:320578"
     Region          24..50
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320578"
     Region          24..44
                     /region_name="Transmembrane region"
                     /note="Helical; Name=1. /evidence=ECO:0000255."
     Region          45..52
                     /region_name="Topological domain"
                     /note="Cytoplasmic. /evidence=ECO:0000255."
     Region          53..73
                     /region_name="Transmembrane region"
                     /note="Helical; Name=2. /evidence=ECO:0000255."
     Region          57..83
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320578"
     Region          74..97
                     /region_name="Topological domain"
                     /note="Extracellular. /evidence=ECO:0000255."
     Site            order(79,82..83,95..100,102..103,106,151,153..157,192,
                     195..197,199..201,203..204,249,252..253,255..256,259,
                     265..266,268..270,273,276..277)
                     /site_type="other"
                     /note="putative ligand binding pocket [chemical binding]"
                     /db_xref="CDD:320578"
     Bond            bond(95,186)
                     /bond_type="disulfide"
                     /note="/evidence=ECO:0000255|PROSITE-ProRule:PRU00521."
     Region          95..125
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320578"
     Region          98..118
                     /region_name="Transmembrane region"
                     /note="Helical; Name=3. /evidence=ECO:0000255."
     Region          119..137
                     /region_name="Topological domain"
                     /note="Cytoplasmic. /evidence=ECO:0000255."
     Region          138..159
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320578"
     Region          138..158
                     /region_name="Transmembrane region"
                     /note="Helical; Name=4. /evidence=ECO:0000255."
     Region          159..194
                     /region_name="Topological domain"
                     /note="Extracellular. /evidence=ECO:0000255."
     Region          192..222
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320578"
     Region          195..214
                     /region_name="Transmembrane region"
                     /note="Helical; Name=5. /evidence=ECO:0000255."
     Region          215..234
                     /region_name="Topological domain"
                     /note="Cytoplasmic. /evidence=ECO:0000255."
     Region          229..259
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320578"
     Region          235..255
                     /region_name="Transmembrane region"
                     /note="Helical; Name=6. /evidence=ECO:0000255."
     Region          256..268
                     /region_name="Topological domain"
                     /note="Extracellular. /evidence=ECO:0000255."
     Site            262
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255."
     Region          266..291
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320578"
     Region          269..289
                     /region_name="Transmembrane region"
                     /note="Helical; Name=7. /evidence=ECO:0000255."
     Region          276
                     /region_name="Variant"
                     /note="T -> K (in dbSNP:rs4936845). /id=VAR_053222."
     Region          290..313
                     /region_name="Topological domain"
                     /note="Cytoplasmic. /evidence=ECO:0000255."
ORIGIN      
        1 mgnwstvtei tliafpalle irislfvvlv vtytltatgn itiisliwid hrlqtpmyff
       61 lsnlsfldil yttvitpkll acllgeekti sfagcmiqty fyfflgtvef illavmsfdr
      121 ymaicdplhy tvimnsracl llvlgcwvga flsvlfptiv vtrlpycrke inhffcdiap
      181 llqvacinth liekinflls alvilsslaf ttgsyvyiis tilripstqg rqkafstcas
      241 hitvvsiahg snifvyvrpn qnssldydkv aavlitvvtp llnpfiyslr nekvqevlre
      301 tvnrimtliq rkt
//
Feature
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Reference sequence information

  • RefSeq protein
    See the reference protein sequence for olfactory receptor 6M1 (NP_001005325.1).

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