LOCUS OR6M1_HUMAN 313 aa linear PRI 27-NOV-2024
DEFINITION RecName: Full=Olfactory receptor 6M1; AltName: Full=Olfactory
receptor OR11-271.
ACCESSION Q8NGM8
VERSION Q8NGM8.1
DBSOURCE UniProtKB: locus OR6M1_HUMAN, accession Q8NGM8;
class: standard.
extra accessions:B2RNK0,Q6IEW9,Q96R37
created: Oct 10, 2003.
sequence updated: Oct 1, 2002.
annotation updated: Nov 27, 2024.
xrefs: AB065762.1, BAC05982.1, CH471065.1, EAW67556.1, BC136929.1,
AAI36930.1, BC136931.1, AAI36932.1, AF399606.1, AAK95091.1,
BK004493.1, DAA04891.1, NP_001005325.1
xrefs (non-sequence databases): CCDS:CCDS31696.1,
AlphaFoldDB:Q8NGM8, SMR:Q8NGM8, BioGRID:133477, IntAct:Q8NGM8,
STRING:9606.ENSP00000311038, GlyCosmos:Q8NGM8, GlyGen:Q8NGM8,
iPTMnet:Q8NGM8, PhosphoSitePlus:Q8NGM8, BioMuta:OR6M1,
MassIVE:Q8NGM8, PaxDb:9606-ENSP00000311038, Antibodypedia:63993,
DNASU:390261, Ensembl:ENST00000309154.3, Ensembl:ENSP00000311038.2,
Ensembl:ENSG00000196099.5, GeneID:390261, KEGG:hsa:390261,
MANE-Select:ENST00000309154.3, UCSC:uc010rzz.3, AGR:HGNC:14711,
CTD:390261, GeneCards:OR6M1, HGNC:14711, HPA:ENSG00000196099,
neXtProt:NX_Q8NGM8, PharmGKB:PA32596,
VEuPathDB:HostDB:ENSG00000196099, eggNOG:ENOG502SFXX,
GeneTree:ENSGT01090000260086, HOGENOM:CLU_012526_1_1_1,
InParanoid:Q8NGM8, OMA:MGNWSTV, OrthoDB:5401587at2759,
PhylomeDB:Q8NGM8, TreeFam:TF336833, PathwayCommons:Q8NGM8,
Reactome:R-HSA-9752946, BioGRID-ORCS:390261, GeneWiki:OR6M1,
GenomeRNAi:390261, Pharos:Q8NGM8, PRO:PR:Q8NGM8,
Proteomes:UP000005640, RNAct:Q8NGM8, Bgee:ENSG00000196099,
ExpressionAtlas:Q8NGM8, GO:0005886, GO:0004930, GO:0004984,
CDD:cd15912, FunFam:1.20.1070.10:FF:000010, Gene3D:1.20.1070.10,
InterPro:IPR000276, InterPro:IPR017452, InterPro:IPR000725,
InterPro:IPR047132, PANTHER:PTHR26454, PANTHER:PTHR26454:SF51,
Pfam:PF00001, PRINTS:PR00237, PRINTS:PR00245, SUPFAM:SSF81321,
PROSITE:PS00237, PROSITE:PS50262
KEYWORDS Cell membrane; Disulfide bond; G-protein coupled receptor;
Glycoprotein; Membrane; Olfaction; Receptor; Reference proteome;
Sensory transduction; Transducer; Transmembrane; Transmembrane
helix.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 313)
AUTHORS Suwa,M., Sato,T., Okouchi,I., Arita,M., Futami,K., Matsumoto,S.,
Tsutsumi,S., Aburatani,H., Asai,K. and Akiyama,Y.
TITLE Direct Submission
JOURNAL Submitted (??-JUL-2001) to the EMBL/GenBank/DDBJ databases
REMARK NUCLEOTIDE SEQUENCE [GENOMIC DNA].
REFERENCE 2 (residues 1 to 313)
AUTHORS Mural,R.J., Istrail,S., Sutton,G.G., Florea,L., Halpern,A.L.,
Mobarry,C.M., Lippert,R., Walenz,B., Shatkay,H., Dew,I.,
Miller,J.R., Flanigan,M.J., Edwards,N.J., Bolanos,R., Fasulo,D.,
Halldorsson,B.V., Hannenhalli,S., Turner,R., Yooseph,S., Lu,F.,
Nusskern,D.R., Shue,B.C., Zheng,X.H., Zhong,F., Delcher,A.L.,
Huson,D.H., Kravitz,S.A., Mouchard,L., Reinert,K., Remington,K.A.,
Clark,A.G., Waterman,M.S., Eichler,E.E., Adams,M.D.,
Hunkapiller,M.W., Myers,E.W. and Venter,J.C.
TITLE Direct Submission
JOURNAL Submitted (??-JUL-2005) to the EMBL/GenBank/DDBJ databases
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
REFERENCE 3 (residues 1 to 313)
AUTHORS Gerhard,D.S., Wagner,L., Feingold,E.A., Shenmen,C.M., Grouse,L.H.,
Schuler,G., Klein,S.L., Old,S., Rasooly,R., Good,P., Guyer,M.,
Peck,A.M., Derge,J.G., Lipman,D., Collins,F.S., Jang,W., Sherry,S.,
Feolo,M., Misquitta,L., Lee,E., Rotmistrovsky,K., Greenhut,S.F.,
Schaefer,C.F., Buetow,K., Bonner,T.I., Haussler,D., Kent,J.,
Kiekhaus,M., Furey,T., Brent,M., Prange,C., Schreiber,K.,
Shapiro,N., Bhat,N.K., Hopkins,R.F., Hsie,F., Driscoll,T.,
Soares,M.B., Casavant,T.L., Scheetz,T.E., Brown-stein,M.J.,
Usdin,T.B., Toshiyuki,S., Carninci,P., Piao,Y., Dudekula,D.B.,
Ko,M.S., Kawakami,K., Suzuki,Y., Sugano,S., Gruber,C.E.,
Smith,M.R., Simmons,B., Moore,T., Waterman,R., Johnson,S.L.,
Ruan,Y., Wei,C.L., Mathavan,S., Gunaratne,P.H., Wu,J., Garcia,A.M.,
Hulyk,S.W., Fuh,E., Yuan,Y., Sneed,A., Kowis,C., Hodgson,A.,
Muzny,D.M., McPherson,J., Gibbs,R.A., Fahey,J., Helton,E.,
Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M.,
Madari,A., Young,A.C., Wetherby,K.D., Granite,S.J., Kwong,P.N.,
Brinkley,C.P., Pearson,R.L., Bouffard,G.G., Blakesly,R.W.,
Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J.,
Myers,R.M., Butterfield,Y.S., Griffith,M., Griffith,O.L.,
Krzywinski,M.I., Liao,N., Morin,R., Palmquist,D., Petrescu,A.S.,
Skalska,U., Smailus,D.E., Stott,J.M., Schnerch,A., Schein,J.E.,
Jones,S.J., Holt,R.A., Baross,A., Marra,M.A., Clifton,S.,
Makowski,K.A., Bosak,S. and Malek,J.
CONSRTM MGC Project Team
TITLE The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC)
JOURNAL Genome Res 14 (10B), 2121-2127 (2004)
PUBMED 15489334
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Erratum:[Genome Res. 2006 Jun;16(6):804. Morrin, Ryan [corrected to
Morin, Ryan]]
REFERENCE 4 (residues 1 to 313)
AUTHORS Fuchs,T., Malecova,B., Linhart,C., Sharan,R., Khen,M., Herwig,R.,
Shmulevich,D., Elkon,R., Steinfath,M., O'Brien,J.K., Radelof,U.,
Lehrach,H., Lancet,D. and Shamir,R.
TITLE DEFOG: a practical scheme for deciphering families of genes
JOURNAL Genomics 80 (3), 295-302 (2002)
PUBMED 12213199
REMARK NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-281.
REFERENCE 5 (residues 1 to 313)
AUTHORS Malnic,B., Godfrey,P.A. and Buck,L.B.
TITLE The human olfactory receptor gene family
JOURNAL Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
PUBMED 14983052
REMARK IDENTIFICATION.
Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE 6 (residues 1 to 313)
AUTHORS Malnic,B., Godfrey,P.A. and Buck,L.B.
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 101, 7205-7205 (2004)
REMARK ERRATUM OF PUBMED:14983052.
COMMENT [FUNCTION] Odorant receptor. {ECO:0000305}.
[SUBCELLULAR LOCATION] Cell membrane; Multi-pass membrane protein.
[SIMILARITY] Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
[WEB RESOURCE] Name=Human Olfactory Receptor Data Exploratorium
(HORDE);
URL='http://genome.weizmann.ac.il/horde/card/index/symbol:OR6M1'.
FEATURES Location/Qualifiers
source 1..313
/organism="Homo sapiens"
/db_xref="taxon:9606"
gene 1..313
/gene="OR6M1"
Protein 1..313
/product="Olfactory receptor 6M1"
/note="Olfactory receptor OR11-271"
/UniProtKB_evidence="Evidence at transcript level"
Region 1..313
/region_name="Mature chain"
/note="Olfactory receptor 6M1. /id=PRO_0000150632."
Region 1..23
/region_name="Topological domain"
/note="Extracellular. /evidence=ECO:0000255."
Site 3
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255."
Region 23..291
/region_name="7tmA_OR6C-like"
/note="olfactory receptor subfamily 6C and related
proteins, member of the class A family of
seven-transmembrane G protein-coupled receptors; cd15912"
/db_xref="CDD:320578"
Region 24..50
/region_name="TM helix 1"
/note="TM helix 1 [structural motif]"
/db_xref="CDD:320578"
Region 24..44
/region_name="Transmembrane region"
/note="Helical; Name=1. /evidence=ECO:0000255."
Region 45..52
/region_name="Topological domain"
/note="Cytoplasmic. /evidence=ECO:0000255."
Region 53..73
/region_name="Transmembrane region"
/note="Helical; Name=2. /evidence=ECO:0000255."
Region 57..83
/region_name="TM helix 2"
/note="TM helix 2 [structural motif]"
/db_xref="CDD:320578"
Region 74..97
/region_name="Topological domain"
/note="Extracellular. /evidence=ECO:0000255."
Site order(79,82..83,95..100,102..103,106,151,153..157,192,
195..197,199..201,203..204,249,252..253,255..256,259,
265..266,268..270,273,276..277)
/site_type="other"
/note="putative ligand binding pocket [chemical binding]"
/db_xref="CDD:320578"
Bond bond(95,186)
/bond_type="disulfide"
/note="/evidence=ECO:0000255|PROSITE-ProRule:PRU00521."
Region 95..125
/region_name="TM helix 3"
/note="TM helix 3 [structural motif]"
/db_xref="CDD:320578"
Region 98..118
/region_name="Transmembrane region"
/note="Helical; Name=3. /evidence=ECO:0000255."
Region 119..137
/region_name="Topological domain"
/note="Cytoplasmic. /evidence=ECO:0000255."
Region 138..159
/region_name="TM helix 4"
/note="TM helix 4 [structural motif]"
/db_xref="CDD:320578"
Region 138..158
/region_name="Transmembrane region"
/note="Helical; Name=4. /evidence=ECO:0000255."
Region 159..194
/region_name="Topological domain"
/note="Extracellular. /evidence=ECO:0000255."
Region 192..222
/region_name="TM helix 5"
/note="TM helix 5 [structural motif]"
/db_xref="CDD:320578"
Region 195..214
/region_name="Transmembrane region"
/note="Helical; Name=5. /evidence=ECO:0000255."
Region 215..234
/region_name="Topological domain"
/note="Cytoplasmic. /evidence=ECO:0000255."
Region 229..259
/region_name="TM helix 6"
/note="TM helix 6 [structural motif]"
/db_xref="CDD:320578"
Region 235..255
/region_name="Transmembrane region"
/note="Helical; Name=6. /evidence=ECO:0000255."
Region 256..268
/region_name="Topological domain"
/note="Extracellular. /evidence=ECO:0000255."
Site 262
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255."
Region 266..291
/region_name="TM helix 7"
/note="TM helix 7 [structural motif]"
/db_xref="CDD:320578"
Region 269..289
/region_name="Transmembrane region"
/note="Helical; Name=7. /evidence=ECO:0000255."
Region 276
/region_name="Variant"
/note="T -> K (in dbSNP:rs4936845). /id=VAR_053222."
Region 290..313
/region_name="Topological domain"
/note="Cytoplasmic. /evidence=ECO:0000255."
ORIGIN
1 mgnwstvtei tliafpalle irislfvvlv vtytltatgn itiisliwid hrlqtpmyff
61 lsnlsfldil yttvitpkll acllgeekti sfagcmiqty fyfflgtvef illavmsfdr
121 ymaicdplhy tvimnsracl llvlgcwvga flsvlfptiv vtrlpycrke inhffcdiap
181 llqvacinth liekinflls alvilsslaf ttgsyvyiis tilripstqg rqkafstcas
241 hitvvsiahg snifvyvrpn qnssldydkv aavlitvvtp llnpfiyslr nekvqevlre
301 tvnrimtliq rkt
//