RecName: Full=Aldo-keto reductase family 1 member C3; AltName: Full=17 - Protein

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AKR1C3 silencing inhibits autophagy-dependent glycolysis in thyroid cancer cells by inactivating ERK signaling. [Drug Dev Res. 2024]
AKR1C3 silencing inhibits autophagy-dependent glycolysis in thyroid cancer cells by inactivating ERK signaling.
Gao Y, Tao W, Wang S, Duan R, Zhang Z. Drug Dev Res. 2024 Feb; 85(1):e22142.
Aldo-keto reductase family member C3 (AKR1C3) promotes hepatocellular carcinoma cell growth by producing prostaglandin F2α. [Oncol Res. 2023]
Aldo-keto reductase family member C3 (AKR1C3) promotes hepatocellular carcinoma cell growth by producing prostaglandin F2α.
Jeng KS, Cheng PY, Lin YH, Liu PC, Tseng PH, Wang YC, Chang CF, Leu CM. Oncol Res. 2023; 32(1):163-174. Epub 2023 Nov 15.
Inhibition of aldo-keto reductase 1C3 overcomes gemcitabine/cisplatin resistance in bladder cancer. [Chem Biol Interact. 2024]
Inhibition of aldo-keto reductase 1C3 overcomes gemcitabine/cisplatin resistance in bladder cancer.
Himura R, Kawano S, Nagata Y, Kawai M, Ota A, Kudo Y, Yoshino Y, Fujimoto N, Miyamoto H, Endo S, et al. Chem Biol Interact. 2024 Jan 25; 388:110840. Epub 2023 Dec 18.

RefSeq genomic sequence
See the genomic reference sequence for the AKR1C3 gene (NG_047094.1).
RefSeq protein isoforms
See 3 reference sequence protein isoforms for the AKR1C3 gene.

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P42330 [Domain Mapping of Disease Mut...]
P42330
Domain Mapping of Disease Mutations
Transcript/Protein Information [PANTHER Classification System]
Transcript/Protein Information
PANTHER Classification System
Reactome [Reactome]
Reactome
reagents [ExactAntigen/Labome]
reagents
ExactAntigen/Labome
reagent reviews [ExactAntigen/Labome]
reagent reviews
ExactAntigen/Labome
Evolutionary Trace of Functional Site [Evolutionary Trace of Functio...]
Evolutionary Trace of Functional Site

RecName: Full=Aldo-keto reductase family 1 member C3; AltName: Full=17-beta-hydr...
RecName: Full=Aldo-keto reductase family 1 member C3; AltName: Full=17-beta-hydroxysteroid dehydrogenase type 5; Short=17-beta-HSD 5; AltName: Full=3-alpha-HSD type II, brain; AltName: Full=3-alpha-hydroxysteroid dehydrogenase type 2; Short=3-alpha-HSD type 2; AltName: Full=Chlordecone reductase homolog HAKRb; AltName: Full=Dihydrodiol dehydrogenase 3; Short=DD-3; Short=DD3; AltName: Full=Dihydrodiol dehydrogenase type I; AltName: Full=HA1753; AltName: Full=Prostaglandin F synthase; Short=PGFS; AltName: Full=Testosterone 17-beta-dehydrogenase 5
gi|308153646|sp|P42330.4|AK1C3_HUMA

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