LOCUS NP_775820 374 aa linear PRI 16-JUL-2024
DEFINITION glutamate-rich protein 5 isoform 1 [Homo sapiens].
ACCESSION NP_775820
VERSION NP_775820.2
DBSOURCE REFSEQ: accession NM_173549.3
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 374)
AUTHORS Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
TITLE CFTR interactome mapping using the mammalian membrane two-hybrid
high-throughput screening system
JOURNAL Mol Syst Biol 18 (2), e10629 (2022)
PUBMED 35156780
REFERENCE 2 (residues 1 to 374)
AUTHORS Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
TITLE A reference map of the human binary protein interactome
JOURNAL Nature 580 (7803), 402-408 (2020)
PUBMED 32296183
REFERENCE 3 (residues 1 to 374)
AUTHORS Rothenberg,M.E., Spergel,J.M., Sherrill,J.D., Annaiah,K.,
Martin,L.J., Cianferoni,A., Gober,L., Kim,C., Glessner,J.,
Frackelton,E., Thomas,K., Blanchard,C., Liacouras,C., Verma,R.,
Aceves,S., Collins,M.H., Brown-Whitehorn,T., Putnam,P.E.,
Franciosi,J.P., Chiavacci,R.M., Grant,S.F., Abonia,J.P.,
Sleiman,P.M. and Hakonarson,H.
TITLE Common variants at 5q22 associate with pediatric eosinophilic
esophagitis
JOURNAL Nat Genet 42 (4), 289-291 (2010)
PUBMED 20208534
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AK096872.1 and BC062359.1.
On Jan 1, 2010 this sequence version replaced NP_775820.1.
Transcript Variant: This variant represents the longer transcript
and encodes the longer isoform (1).
##Evidence-Data-START##
Transcript exon combination :: AK096872.1, SRR3476690.14670.1
[ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1965299, SAMEA1968540
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000318528.8/ ENSP00000315614.3
RefSeq Select criteria :: based on expression, longest protein
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..374
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="8"
/map="8q22.2"
Protein 1..374
/product="glutamate-rich protein 5 isoform 1"
/note="glutamate-rich protein 5"
/calculated_mol_wt=39805
Region 1..168
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q6P6B1.1)"
Region 94..267
/region_name="DUF4573"
/note="Domain of unknown function (DUF4573); pfam15140"
/db_xref="CDD:434493"
Site 169
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q8K0S2; propagated from
UniProtKB/Swiss-Prot (Q6P6B1.1)"
Region 241..299
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q6P6B1.1)"
Region 328..374
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q6P6B1.1)"
CDS 1..374
/gene="ERICH5"
/gene_synonym="C8orf47"
/coded_by="NM_173549.3:103..1227"
/note="isoform 1 is encoded by transcript variant 1"
/db_xref="CCDS:CCDS34929.1"
/db_xref="GeneID:203111"
/db_xref="HGNC:HGNC:26823"
/db_xref="MIM:620895"
ORIGIN
1 mgcsssalnk agdssrfpsv tsnehfstae esescfaqpk phalgrestv dgnvqresrp
61 plqklkvsae ptangvkplq eqplakdvap grdatdqsgs tektqpgegl eesgppqpgg
121 kedapaaegk kkdagagtea eslkgnaeaq plgpeakgqp lqaavekdsl ravevtenpq
181 taaemkplgt tenvltlqia gelqpqgtvg kdeqapllet iskenespei legsqfveta
241 eeqqlqatlg keeqpqller ipkenvtpev ldrsqlvekp vmndpfhktp egpgnmeqiq
301 pegivgsmeh parnveagay vemirnihtn eedqrieget gekvetdmen ekvsegaetk
361 eeetgevvdl saat
//