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glutamate-rich protein 5 isoform 1 [Homo sapiens]

NCBI Reference Sequence: NP_775820.2

Identical Proteins FASTA Graphics 

LOCUS       NP_775820                374 aa            linear   PRI 16-JUL-2024
DEFINITION  glutamate-rich protein 5 isoform 1 [Homo sapiens].
ACCESSION   NP_775820
VERSION     NP_775820.2
DBSOURCE    REFSEQ: accession NM_173549.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 374)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   2  (residues 1 to 374)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (residues 1 to 374)
  AUTHORS   Rothenberg,M.E., Spergel,J.M., Sherrill,J.D., Annaiah,K.,
            Martin,L.J., Cianferoni,A., Gober,L., Kim,C., Glessner,J.,
            Frackelton,E., Thomas,K., Blanchard,C., Liacouras,C., Verma,R.,
            Aceves,S., Collins,M.H., Brown-Whitehorn,T., Putnam,P.E.,
            Franciosi,J.P., Chiavacci,R.M., Grant,S.F., Abonia,J.P.,
            Sleiman,P.M. and Hakonarson,H.
  TITLE     Common variants at 5q22 associate with pediatric eosinophilic
            esophagitis
  JOURNAL   Nat Genet 42 (4), 289-291 (2010)
   PUBMED   20208534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK096872.1 and BC062359.1.
            
            On Jan 1, 2010 this sequence version replaced NP_775820.1.
            
            Transcript Variant: This variant represents the longer transcript
            and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK096872.1, SRR3476690.14670.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000318528.8/ ENSP00000315614.3
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..374
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.2"
     Protein         1..374
                     /product="glutamate-rich protein 5 isoform 1"
                     /note="glutamate-rich protein 5"
                     /calculated_mol_wt=39805
     Region          1..168
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P6B1.1)"
     Region          94..267
                     /region_name="DUF4573"
                     /note="Domain of unknown function (DUF4573); pfam15140"
                     /db_xref="CDD:434493"
     Site            169
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8K0S2; propagated from
                     UniProtKB/Swiss-Prot (Q6P6B1.1)"
     Region          241..299
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P6B1.1)"
     Region          328..374
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P6B1.1)"
     CDS             1..374
                     /gene="ERICH5"
                     /gene_synonym="C8orf47"
                     /coded_by="NM_173549.3:103..1227"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS34929.1"
                     /db_xref="GeneID:203111"
                     /db_xref="HGNC:HGNC:26823"
                     /db_xref="MIM:620895"
ORIGIN      
        1 mgcsssalnk agdssrfpsv tsnehfstae esescfaqpk phalgrestv dgnvqresrp
       61 plqklkvsae ptangvkplq eqplakdvap grdatdqsgs tektqpgegl eesgppqpgg
      121 kedapaaegk kkdagagtea eslkgnaeaq plgpeakgqp lqaavekdsl ravevtenpq
      181 taaemkplgt tenvltlqia gelqpqgtvg kdeqapllet iskenespei legsqfveta
      241 eeqqlqatlg keeqpqller ipkenvtpev ldrsqlvekp vmndpfhktp egpgnmeqiq
      301 pegivgsmeh parnveagay vemirnihtn eedqrieget gekvetdmen ekvsegaetk
      361 eeetgevvdl saat
//
Feature
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Reference sequence information

  • RefSeq mRNA
    See reference mRNA sequence for the ERICH5 gene (NM_173549.3).
  • RefSeq protein isoforms
    See the other reference sequence protein isoform for the ERICH5 gene (NP_001164277.1).

More about the ERICH5 gene

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