LOCUS NP_956574 378 aa linear VRT 13-DEC-2024
DEFINITION prostaglandin E synthase 2 [Danio rerio].
ACCESSION NP_956574 XP_001337986
VERSION NP_956574.2
DBSOURCE REFSEQ: accession NM_200280.2
KEYWORDS RefSeq.
SOURCE Danio rerio (zebrafish)
ORGANISM Danio rerio
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE 1 (residues 1 to 378)
AUTHORS Crespo,D., Lemos,M.S., Zhang,Y.T., Safian,D., Norberg,B., Bogerd,J.
and Schulz,R.W.
TITLE PGE2 inhibits spermatogonia differentiation in zebrafish:
interaction with Fsh and an androgen
JOURNAL J Endocrinol 244 (1), 163-175 (2020)
PUBMED 31600720
REFERENCE 2 (residues 1 to 378)
AUTHORS Bayes,A., Collins,M.O., Reig-Viader,R., Gou,G., Goulding,D.,
Izquierdo,A., Choudhary,J.S., Emes,R.D. and Grant,S.G.
TITLE Evolution of complexity in the zebrafish synapse proteome
JOURNAL Nat Commun 8, 14613 (2017)
PUBMED 28252024
REMARK Publication Status: Online-Only
REFERENCE 3 (residues 1 to 378)
AUTHORS Pradhan,A. and Olsson,P.E.
TITLE Zebrafish sexual behavior: role of sex steroid hormones and
prostaglandins
JOURNAL Behav Brain Funct 11, 23 (2015)
PUBMED 26385780
REMARK Publication Status: Online-Only
REFERENCE 4 (residues 1 to 378)
AUTHORS Pradhan,A. and Olsson,P.E.
TITLE Inhibition of retinoic acid synthesis disrupts spermatogenesis and
fecundity in zebrafish
JOURNAL Gen Comp Endocrinol 217-218, 81-91 (2015)
PUBMED 25687389
REFERENCE 5 (residues 1 to 378)
AUTHORS Pradhan,A. and Olsson,P.E.
TITLE Juvenile ovary to testis transition in zebrafish involves
inhibition of ptges
JOURNAL Biol Reprod 91 (2), 33 (2014)
PUBMED 24920039
REFERENCE 6 (residues 1 to 378)
AUTHORS Mueller,R.L., Huang,C. and Ho,R.K.
TITLE Spatio-temporal regulation of Wnt and retinoic acid signaling by
tbx16/spadetail during zebrafish mesoderm differentiation
JOURNAL BMC Genomics 11, 492 (2010)
PUBMED 20828405
REMARK Publication Status: Online-Only
REFERENCE 7 (residues 1 to 378)
AUTHORS Jorgensen,A., Nielsen,J.E., Nielsen,B.F., Morthorst,J.E.,
Bjerregaard,P. and Leffers,H.
TITLE Expression of prostaglandin synthases (pgds and pges) during
zebrafish gonadal differentiation
JOURNAL Comp Biochem Physiol A Mol Integr Physiol 157 (1), 102-108 (2010)
PUBMED 20362066
REFERENCE 8 (residues 1 to 378)
AUTHORS Lister,A., Regan,C., Van Zwol,J. and Van Der Kraak,G.
TITLE Inhibition of egg production in zebrafish by fluoxetine and
municipal effluents: a mechanistic evaluation
JOURNAL Aquat Toxicol 95 (4), 320-329 (2009)
PUBMED 19493577
REFERENCE 9 (residues 1 to 378)
AUTHORS Lister,A.L. and Van Der Kraak,G.J.
TITLE Regulation of prostaglandin synthesis in ovaries of sexually-mature
zebrafish (Danio rerio)
JOURNAL Mol Reprod Dev 76 (11), 1064-1075 (2009)
PUBMED 19551897
REFERENCE 10 (residues 1 to 378)
AUTHORS Lister,A.L. and Van Der Kraak,G.
TITLE An investigation into the role of prostaglandins in zebrafish
oocyte maturation and ovulation
JOURNAL Gen Comp Endocrinol 159 (1), 46-57 (2008)
PUBMED 18722378
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BX640472.24.
On Jun 21, 2024 this sequence version replaced NP_956574.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC049325.1, GDQQ01005725.1
[ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA3505370, SAMEA3505371
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..378
/organism="Danio rerio"
/strain="Tuebingen"
/db_xref="taxon:7955"
/chromosome="8"
/map="8"
Protein 1..378
/product="prostaglandin E synthase 2"
/EC_number="5.3.99.3"
/note="mPGES-2; microsomal prostaglandin E synthase 2"
/calculated_mol_wt=42777
CDS 1..378
/gene="ptgesl"
/gene_synonym="ptges2; zgc:56527"
/coded_by="NM_200280.2:54..1190"
/db_xref="GeneID:799964"
/db_xref="ZFIN:ZDB-GENE-040426-1063"
ORIGIN
1 mmaaactrtl gkvgrlvldt ptcrftntaa fvprtsmrcq graygtgssg fksrlllaap
61 vrgsgrvlgc afllgggfgl yqtikltlqh hlaekeadas dldtdlkltl yqyktcpfcs
121 kvrafldyhr lpyeivevnp vmrqeikwst yrkvpilmvn gtvqlndssv iisalktyis
181 skdkkiseil acypemkskn drgkdviefg nkywvmvhda dadqlypgkd srkeeikwrt
241 waddwlvhli spnvyrtpte alasfdyivr egkfgsfegf fakyfgaaam wiiskrlkyk
301 hnlqadvrqd lykavndwva aigknkqfmg gdepnladla vfgvlrvmeg lqsfddmmeh
361 tkvkkwysrm qkatqhvs
//