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prostaglandin E synthase 2 [Danio rerio]

NCBI Reference Sequence: NP_956574.2

Identical Proteins FASTA Graphics 

LOCUS       NP_956574                378 aa            linear   VRT 13-DEC-2024
DEFINITION  prostaglandin E synthase 2 [Danio rerio].
ACCESSION   NP_956574 XP_001337986
VERSION     NP_956574.2
DBSOURCE    REFSEQ: accession NM_200280.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 378)
  AUTHORS   Crespo,D., Lemos,M.S., Zhang,Y.T., Safian,D., Norberg,B., Bogerd,J.
            and Schulz,R.W.
  TITLE     PGE2 inhibits spermatogonia differentiation in zebrafish:
            interaction with Fsh and an androgen
  JOURNAL   J Endocrinol 244 (1), 163-175 (2020)
   PUBMED   31600720
REFERENCE   2  (residues 1 to 378)
  AUTHORS   Bayes,A., Collins,M.O., Reig-Viader,R., Gou,G., Goulding,D.,
            Izquierdo,A., Choudhary,J.S., Emes,R.D. and Grant,S.G.
  TITLE     Evolution of complexity in the zebrafish synapse proteome
  JOURNAL   Nat Commun 8, 14613 (2017)
   PUBMED   28252024
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 378)
  AUTHORS   Pradhan,A. and Olsson,P.E.
  TITLE     Zebrafish sexual behavior: role of sex steroid hormones and
            prostaglandins
  JOURNAL   Behav Brain Funct 11, 23 (2015)
   PUBMED   26385780
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 378)
  AUTHORS   Pradhan,A. and Olsson,P.E.
  TITLE     Inhibition of retinoic acid synthesis disrupts spermatogenesis and
            fecundity in zebrafish
  JOURNAL   Gen Comp Endocrinol 217-218, 81-91 (2015)
   PUBMED   25687389
REFERENCE   5  (residues 1 to 378)
  AUTHORS   Pradhan,A. and Olsson,P.E.
  TITLE     Juvenile ovary to testis transition in zebrafish involves
            inhibition of ptges
  JOURNAL   Biol Reprod 91 (2), 33 (2014)
   PUBMED   24920039
REFERENCE   6  (residues 1 to 378)
  AUTHORS   Mueller,R.L., Huang,C. and Ho,R.K.
  TITLE     Spatio-temporal regulation of Wnt and retinoic acid signaling by
            tbx16/spadetail during zebrafish mesoderm differentiation
  JOURNAL   BMC Genomics 11, 492 (2010)
   PUBMED   20828405
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 378)
  AUTHORS   Jorgensen,A., Nielsen,J.E., Nielsen,B.F., Morthorst,J.E.,
            Bjerregaard,P. and Leffers,H.
  TITLE     Expression of prostaglandin synthases (pgds and pges) during
            zebrafish gonadal differentiation
  JOURNAL   Comp Biochem Physiol A Mol Integr Physiol 157 (1), 102-108 (2010)
   PUBMED   20362066
REFERENCE   8  (residues 1 to 378)
  AUTHORS   Lister,A., Regan,C., Van Zwol,J. and Van Der Kraak,G.
  TITLE     Inhibition of egg production in zebrafish by fluoxetine and
            municipal effluents: a mechanistic evaluation
  JOURNAL   Aquat Toxicol 95 (4), 320-329 (2009)
   PUBMED   19493577
REFERENCE   9  (residues 1 to 378)
  AUTHORS   Lister,A.L. and Van Der Kraak,G.J.
  TITLE     Regulation of prostaglandin synthesis in ovaries of sexually-mature
            zebrafish (Danio rerio)
  JOURNAL   Mol Reprod Dev 76 (11), 1064-1075 (2009)
   PUBMED   19551897
REFERENCE   10 (residues 1 to 378)
  AUTHORS   Lister,A.L. and Van Der Kraak,G.
  TITLE     An investigation into the role of prostaglandins in zebrafish
            oocyte maturation and ovulation
  JOURNAL   Gen Comp Endocrinol 159 (1), 46-57 (2008)
   PUBMED   18722378
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX640472.24.
            
            On Jun 21, 2024 this sequence version replaced NP_956574.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049325.1, GDQQ01005725.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505371
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..378
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="8"
                     /map="8"
     Protein         1..378
                     /product="prostaglandin E synthase 2"
                     /EC_number="5.3.99.3"
                     /note="mPGES-2; microsomal prostaglandin E synthase 2"
                     /calculated_mol_wt=42777
     CDS             1..378
                     /gene="ptgesl"
                     /gene_synonym="ptges2; zgc:56527"
                     /coded_by="NM_200280.2:54..1190"
                     /db_xref="GeneID:799964"
                     /db_xref="ZFIN:ZDB-GENE-040426-1063"
ORIGIN      
        1 mmaaactrtl gkvgrlvldt ptcrftntaa fvprtsmrcq graygtgssg fksrlllaap
       61 vrgsgrvlgc afllgggfgl yqtikltlqh hlaekeadas dldtdlkltl yqyktcpfcs
      121 kvrafldyhr lpyeivevnp vmrqeikwst yrkvpilmvn gtvqlndssv iisalktyis
      181 skdkkiseil acypemkskn drgkdviefg nkywvmvhda dadqlypgkd srkeeikwrt
      241 waddwlvhli spnvyrtpte alasfdyivr egkfgsfegf fakyfgaaam wiiskrlkyk
      301 hnlqadvrqd lykavndwva aigknkqfmg gdepnladla vfgvlrvmeg lqsfddmmeh
      361 tkvkkwysrm qkatqhvs
//
Feature
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