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cytochrome P450, family 2, subfamily AD, polypeptide 2 [Danio rerio]

NCBI Reference Sequence: NP_694486.1

Identical Proteins FASTA Graphics 

LOCUS       NP_694486                492 aa            linear   VRT 24-NOV-2018
DEFINITION  cytochrome P450, family 2, subfamily AD, polypeptide 2 [Danio
            rerio].
ACCESSION   NP_694486
VERSION     NP_694486.1
DBSOURCE    REFSEQ: accession NM_152954.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 492)
  AUTHORS   Puthumana J, Kim BM, Jeong CB, Kim DH, Kang HM, Jung JH, Kim IC,
            Hwang UK and Lee JS.
  TITLE     Nine co-localized cytochrome P450 genes of the CYP2N, CYP2AD, and
            CYP2P gene families in the mangrove killifish Kryptolebias
            marmoratus genome: Identification and expression in response to
            B[alpha]P, BPA, OP, and NP
  JOURNAL   Aquat. Toxicol. 187, 132-140 (2017)
   PUBMED   28411468
REFERENCE   2  (residues 1 to 492)
  AUTHORS   Hu P, Liu M, Zhang D, Wang J, Niu H, Liu Y, Wu Z, Han B, Zhai W,
            Shen Y and Chen L.
  TITLE     Global identification of the genetic networks and cis-regulatory
            elements of the cold response in zebrafish
  JOURNAL   Nucleic Acids Res. 43 (19), 9198-9213 (2015)
   PUBMED   26227973
REFERENCE   3  (residues 1 to 492)
  AUTHORS   Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
            Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
            Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
            GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
            Hertzano R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 492)
  AUTHORS   Zheng W, Xu H, Lam SH, Luo H, Karuturi RK and Gong Z.
  TITLE     Transcriptomic analyses of sexual dimorphism of the zebrafish liver
            and the effect of sex hormones
  JOURNAL   PLoS ONE 8 (1), e53562 (2013)
   PUBMED   23349717
REFERENCE   5  (residues 1 to 492)
  AUTHORS   Warner CM, Gust KA, Stanley JK, Habib T, Wilbanks MS, Garcia-Reyero
            N and Perkins EJ.
  TITLE     A systems toxicology approach to elucidate the mechanisms involved
            in RDX species-specific sensitivity
  JOURNAL   Environ. Sci. Technol. 46 (14), 7790-7798 (2012)
   PUBMED   22697906
REFERENCE   6  (residues 1 to 492)
  AUTHORS   Wang Y and Zhang S.
  TITLE     Identification and expression of liver-specific genes after LPS
            challenge in amphioxus: the hepatic cecum as liver-like organ and
            'pre-hepatic' acute phase response
  JOURNAL   Funct. Integr. Genomics 11 (1), 111-118 (2011)
   PUBMED   21052758
REFERENCE   7  (residues 1 to 492)
  AUTHORS   Kirischian N, McArthur AG, Jesuthasan C, Krattenmacher B and Wilson
            JY.
  TITLE     Phylogenetic and functional analysis of the vertebrate cytochrome
            p450 2 family
  JOURNAL   J. Mol. Evol. 72 (1), 56-71 (2011)
   PUBMED   21116621
REFERENCE   8  (residues 1 to 492)
  AUTHORS   Goldstone JV, McArthur AG, Kubota A, Zanette J, Parente T, Jonsson
            ME, Nelson DR and Stegeman JJ.
  TITLE     Identification and developmental expression of the full complement
            of Cytochrome P450 genes in Zebrafish
  JOURNAL   BMC Genomics 11, 643 (2010)
   PUBMED   21087487
  REMARK    Publication Status: Online-Only
REFERENCE   9  (residues 1 to 492)
  AUTHORS   Ng YK, Wu W and Zhang L.
  TITLE     Positive correlation between gene coexpression and positional
            clustering in the zebrafish genome
  JOURNAL   BMC Genomics 10, 42 (2009)
   PUBMED   19159490
  REMARK    Publication Status: Online-Only
REFERENCE   10 (residues 1 to 492)
  AUTHORS   Cheng W, Guo L, Zhang Z, Soo HM, Wen C, Wu W and Peng J.
  TITLE     HNF factors form a network to regulate liver-enriched genes in
            zebrafish
  JOURNAL   Dev. Biol. 294 (2), 482-496 (2006)
   PUBMED   16631158
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF248042.1.
            
            Sequence Note: This sequence has been modified as follows: removed
            16 bp suspected to be vector contamination from the 5' end.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF248042.1, BC045948.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA2168446, SAMEA2168447
                                           [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Danio rerio"
                     /db_xref="taxon:7955"
                     /chromosome="20"
                     /map="20"
     Protein         1..492
                     /product="cytochrome P450, family 2, subfamily AD,
                     polypeptide 2"
                     /note="ccytochrome P450, family 2, subfamily J,
                     polypeptide 28; cytochrome P450, subfamily IIJ
                     (arachidonic acid epoxygenase) polypeptide a; cytochrome
                     P450, family 2, subfamily J, polypeptide 28"
                     /calculated_mol_wt=56215
     Region          66..487
                     /region_name="cytochrome_P450"
                     /note="cytochrome P450 (CYP) superfamily; cl41757"
                     /db_xref="CDD:477761"
     Site            order(125,129,136,182,297..298,301..302,305..306,309,360,
                     370,372,395,431..433,437..441,444..445)
                     /site_type="other"
                     /note="heme binding site [chemical binding]"
                     /db_xref="CDD:410651"
     Site            order(208..209,297,300..301,305,368..371)
                     /site_type="other"
                     /note="chemical substrate binding pocket [chemical
                     binding]"
                     /db_xref="CDD:410651"
     CDS             1..492
                     /gene="cyp2ad2"
                     /gene_synonym="cyp2j28; cyp2ja; fb62g08; wu:fb62g08"
                     /coded_by="NM_152954.1:40..1518"
                     /db_xref="GeneID:259306"
                     /db_xref="ZFIN:ZDB-GENE-020812-2"
ORIGIN      
        1 milhliydsf dfkswiiffv vfliiaemik nrtpsnyppg pwplpflgtv ftkmdfknin
       61 klakvygkvf slrvgsekmi ivsgykmvke alvtqndsfv lrppvplfhk vykgigltms
      121 ngyiwrshrr faashlrtfg egkknlelgi qqecvylcda fkaekepfnp ifilhgavsn
      181 tvacltfgqr fdyndewyqe ilrldnqcvq lagsprvqly nafpklldyl pgphqkvfsn
      241 ykkitqslkd eiikhredwd panprdfidn yltemekkks dpqagfnies liiscldive
      301 agtetgattl rwgllfmikf peiqkkvqae idrvigqsrq pclddrvnmp yteavlheiq
      361 rfgdvvplgf pkqaavdtki gnyfipkgts ittnlssvlh dpnewetpdt fnpghfldkn
      421 gqfrkrdafl pfsagkracv gellarnvlf lfftsllqqf tlskcpgeep slegeiwfty
      481 apapfrisvs vr
//
Feature
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Reference sequence information

  • RefSeq mRNA
    See reference mRNA sequence for the cyp2ad2 gene (NM_152954.1).

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