LOCUS NP_694486 492 aa linear VRT 24-NOV-2018
DEFINITION cytochrome P450, family 2, subfamily AD, polypeptide 2 [Danio
rerio].
ACCESSION NP_694486
VERSION NP_694486.1
DBSOURCE REFSEQ: accession NM_152954.1
KEYWORDS RefSeq.
SOURCE Danio rerio (zebrafish)
ORGANISM Danio rerio
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE 1 (residues 1 to 492)
AUTHORS Puthumana J, Kim BM, Jeong CB, Kim DH, Kang HM, Jung JH, Kim IC,
Hwang UK and Lee JS.
TITLE Nine co-localized cytochrome P450 genes of the CYP2N, CYP2AD, and
CYP2P gene families in the mangrove killifish Kryptolebias
marmoratus genome: Identification and expression in response to
B[alpha]P, BPA, OP, and NP
JOURNAL Aquat. Toxicol. 187, 132-140 (2017)
PUBMED 28411468
REFERENCE 2 (residues 1 to 492)
AUTHORS Hu P, Liu M, Zhang D, Wang J, Niu H, Liu Y, Wu Z, Han B, Zhai W,
Shen Y and Chen L.
TITLE Global identification of the genetic networks and cis-regulatory
elements of the cold response in zebrafish
JOURNAL Nucleic Acids Res. 43 (19), 9198-9213 (2015)
PUBMED 26227973
REFERENCE 3 (residues 1 to 492)
AUTHORS Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
Hertzano R.
TITLE RFX transcription factors are essential for hearing in mice
JOURNAL Nat Commun 6, 8549 (2015)
PUBMED 26469318
REMARK Publication Status: Online-Only
REFERENCE 4 (residues 1 to 492)
AUTHORS Zheng W, Xu H, Lam SH, Luo H, Karuturi RK and Gong Z.
TITLE Transcriptomic analyses of sexual dimorphism of the zebrafish liver
and the effect of sex hormones
JOURNAL PLoS ONE 8 (1), e53562 (2013)
PUBMED 23349717
REFERENCE 5 (residues 1 to 492)
AUTHORS Warner CM, Gust KA, Stanley JK, Habib T, Wilbanks MS, Garcia-Reyero
N and Perkins EJ.
TITLE A systems toxicology approach to elucidate the mechanisms involved
in RDX species-specific sensitivity
JOURNAL Environ. Sci. Technol. 46 (14), 7790-7798 (2012)
PUBMED 22697906
REFERENCE 6 (residues 1 to 492)
AUTHORS Wang Y and Zhang S.
TITLE Identification and expression of liver-specific genes after LPS
challenge in amphioxus: the hepatic cecum as liver-like organ and
'pre-hepatic' acute phase response
JOURNAL Funct. Integr. Genomics 11 (1), 111-118 (2011)
PUBMED 21052758
REFERENCE 7 (residues 1 to 492)
AUTHORS Kirischian N, McArthur AG, Jesuthasan C, Krattenmacher B and Wilson
JY.
TITLE Phylogenetic and functional analysis of the vertebrate cytochrome
p450 2 family
JOURNAL J. Mol. Evol. 72 (1), 56-71 (2011)
PUBMED 21116621
REFERENCE 8 (residues 1 to 492)
AUTHORS Goldstone JV, McArthur AG, Kubota A, Zanette J, Parente T, Jonsson
ME, Nelson DR and Stegeman JJ.
TITLE Identification and developmental expression of the full complement
of Cytochrome P450 genes in Zebrafish
JOURNAL BMC Genomics 11, 643 (2010)
PUBMED 21087487
REMARK Publication Status: Online-Only
REFERENCE 9 (residues 1 to 492)
AUTHORS Ng YK, Wu W and Zhang L.
TITLE Positive correlation between gene coexpression and positional
clustering in the zebrafish genome
JOURNAL BMC Genomics 10, 42 (2009)
PUBMED 19159490
REMARK Publication Status: Online-Only
REFERENCE 10 (residues 1 to 492)
AUTHORS Cheng W, Guo L, Zhang Z, Soo HM, Wen C, Wu W and Peng J.
TITLE HNF factors form a network to regulate liver-enriched genes in
zebrafish
JOURNAL Dev. Biol. 294 (2), 482-496 (2006)
PUBMED 16631158
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from AF248042.1.
Sequence Note: This sequence has been modified as follows: removed
16 bp suspected to be vector contamination from the 5' end.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF248042.1, BC045948.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
SAMEA2168446, SAMEA2168447
[ECO:0000350]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..492
/organism="Danio rerio"
/db_xref="taxon:7955"
/chromosome="20"
/map="20"
Protein 1..492
/product="cytochrome P450, family 2, subfamily AD,
polypeptide 2"
/note="ccytochrome P450, family 2, subfamily J,
polypeptide 28; cytochrome P450, subfamily IIJ
(arachidonic acid epoxygenase) polypeptide a; cytochrome
P450, family 2, subfamily J, polypeptide 28"
/calculated_mol_wt=56215
Region 66..487
/region_name="cytochrome_P450"
/note="cytochrome P450 (CYP) superfamily; cl41757"
/db_xref="CDD:477761"
Site order(125,129,136,182,297..298,301..302,305..306,309,360,
370,372,395,431..433,437..441,444..445)
/site_type="other"
/note="heme binding site [chemical binding]"
/db_xref="CDD:410651"
Site order(208..209,297,300..301,305,368..371)
/site_type="other"
/note="chemical substrate binding pocket [chemical
binding]"
/db_xref="CDD:410651"
CDS 1..492
/gene="cyp2ad2"
/gene_synonym="cyp2j28; cyp2ja; fb62g08; wu:fb62g08"
/coded_by="NM_152954.1:40..1518"
/db_xref="GeneID:259306"
/db_xref="ZFIN:ZDB-GENE-020812-2"
ORIGIN
1 milhliydsf dfkswiiffv vfliiaemik nrtpsnyppg pwplpflgtv ftkmdfknin
61 klakvygkvf slrvgsekmi ivsgykmvke alvtqndsfv lrppvplfhk vykgigltms
121 ngyiwrshrr faashlrtfg egkknlelgi qqecvylcda fkaekepfnp ifilhgavsn
181 tvacltfgqr fdyndewyqe ilrldnqcvq lagsprvqly nafpklldyl pgphqkvfsn
241 ykkitqslkd eiikhredwd panprdfidn yltemekkks dpqagfnies liiscldive
301 agtetgattl rwgllfmikf peiqkkvqae idrvigqsrq pclddrvnmp yteavlheiq
361 rfgdvvplgf pkqaavdtki gnyfipkgts ittnlssvlh dpnewetpdt fnpghfldkn
421 gqfrkrdafl pfsagkracv gellarnvlf lfftsllqqf tlskcpgeep slegeiwfty
481 apapfrisvs vr
//