LOCUS NP_115514 684 aa linear PRI 18-NOV-2024
DEFINITION kelch repeat and BTB domain-containing protein 7 [Homo sapiens].
ACCESSION NP_115514
VERSION NP_115514.2
DBSOURCE REFSEQ: accession NM_032138.7
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 684)
AUTHORS Li,X., Lin,Z., Xu,S., Zhang,N., Zhou,J. and Liao,B.
TITLE Knockdown of KBTBD7 attenuates septic lung injury by inhibiting
ferroptosis and improving mitochondrial dysfunction
JOURNAL Int Immunopharmacol 133, 112129 (2024)
PUBMED 38652964
REMARK GeneRIF: Knockdown of KBTBD7 attenuates septic lung injury by
inhibiting ferroptosis and improving mitochondrial dysfunction.
REFERENCE 2 (residues 1 to 684)
AUTHORS Zou,Z., Zhang,B., Li,Z., Lei,L., Sun,G., Jiang,X., Guan,J.,
Zhang,Y., Xu,S. and Li,Q.
TITLE KBTBD7 promotes non-small cell lung carcinoma progression by
enhancing ubiquitin-dependent degradation of PTEN
JOURNAL Cancer Med 11 (23), 4544-4554 (2022)
PUBMED 35499228
REMARK GeneRIF: KBTBD7 promotes non-small cell lung carcinoma progression
by enhancing ubiquitin-dependent degradation of PTEN.
Erratum:[Cancer Med. 2024 Sep;13(17):e7462. doi: 10.1002/cam4.7462.
PMID: 39248706]
REFERENCE 3 (residues 1 to 684)
AUTHORS Swaney,D.L., Ramms,D.J., Wang,Z., Park,J., Goto,Y., Soucheray,M.,
Bhola,N., Kim,K., Zheng,F., Zeng,Y., McGregor,M., Herrington,K.A.,
O'Keefe,R., Jin,N., VanLandingham,N.K., Foussard,H., Von Dollen,J.,
Bouhaddou,M., Jimenez-Morales,D., Obernier,K., Kreisberg,J.F.,
Kim,M., Johnson,D.E., Jura,N., Grandis,J.R., Gutkind,J.S.,
Ideker,T. and Krogan,N.J.
TITLE A protein network map of head and neck cancer reveals PIK3CA mutant
drug sensitivity
JOURNAL Science 374 (6563), eabf2911 (2021)
PUBMED 34591642
REFERENCE 4 (residues 1 to 684)
AUTHORS Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
Harper,J.W. and Gygi,S.P.
TITLE Dual proteome-scale networks reveal cell-specific remodeling of the
human interactome
JOURNAL Cell 184 (11), 3022-3040 (2021)
PUBMED 33961781
REFERENCE 5 (residues 1 to 684)
AUTHORS Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
TITLE A reference map of the human binary protein interactome
JOURNAL Nature 580 (7803), 402-408 (2020)
PUBMED 32296183
REFERENCE 6 (residues 1 to 684)
AUTHORS Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
Mann,M.
TITLE A human interactome in three quantitative dimensions organized by
stoichiometries and abundances
JOURNAL Cell 163 (3), 712-723 (2015)
PUBMED 26496610
REFERENCE 7 (residues 1 to 684)
AUTHORS Genau,H.M. and Behrends,C.
TITLE GABARAP proteins as scaffolds in localized TIAM1-RAC1 signaling
JOURNAL Mol Cell Oncol 3 (1), e1027440 (2015)
PUBMED 27308540
REMARK Publication Status: Online-Only
REFERENCE 8 (residues 1 to 684)
AUTHORS Genau,H.M., Huber,J., Baschieri,F., Akutsu,M., Dotsch,V.,
Farhan,H., Rogov,V. and Behrends,C.
TITLE CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP
proteins to spatially restrict TIAM1-RAC1 signaling
JOURNAL Mol Cell 57 (6), 995-1010 (2015)
PUBMED 25684205
REMARK GeneRIF: KBTBD6 and KBTBD7 specifically bind to GABARAP
proteins.KBTBD6 and KBTBD7 form a heterodimeric CRL3 complex.
REFERENCE 9 (residues 1 to 684)
AUTHORS Bennett,E.J., Rush,J., Gygi,S.P. and Harper,J.W.
TITLE Dynamics of cullin-RING ubiquitin ligase network revealed by
systematic quantitative proteomics
JOURNAL Cell 143 (6), 951-965 (2010)
PUBMED 21145461
REFERENCE 10 (residues 1 to 684)
AUTHORS Hu,J., Yuan,W., Tang,M., Wang,Y., Fan,X., Mo,X., Li,Y., Ying,Z.,
Wan,Y., Ocorr,K., Bodmer,R., Deng,Y. and Wu,X.
TITLE KBTBD7, a novel human BTB-kelch protein, activates transcriptional
activities of SRE and AP-1
JOURNAL BMB Rep 43 (1), 17-22 (2010)
PUBMED 20132730
REMARK GeneRIF: KBTBD7 proteins may act as a new transcriptional activator
in mitogen-activated protein kinase (MAPK) signaling.
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AL354696.11, BC022033.2,
AI631319.1, BU070208.1, BF436101.1, HY094395.1 and BU069965.1.
This sequence is a reference standard in the RefSeqGene project.
On Jun 9, 2002 this sequence version replaced NP_115514.1.
Summary: The protein encoded by this gene is a transcriptional
activator, having been shown to increase the transcription of
activator protein-1 and serum response element. The encoded protein
can also form a complex with KBTBD6 and CUL3, which regulates the
ubiquitylation and degradation of TIAM1, which is a regulator of
RAC1. [provided by RefSeq, Jul 2016].
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript is intronless :: AK091344.1, FJ150424.1 [ECO:0000345]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000379483.4/ ENSP00000368797.3
RefSeq Select criteria :: based on single protein-coding transcript
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..684
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="13"
/map="13q14.11"
Protein 1..684
/product="kelch repeat and BTB domain-containing protein
7"
/note="kelch repeat and BTB (POZ) domain containing 7"
/calculated_mol_wt=77033
Region 1..27
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q8WVZ9.1)"
Site 29
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:23186163; propagated from
UniProtKB/Swiss-Prot (Q8WVZ9.1)"
Region 37..178
/region_name="BTB_POZ_KBTBD6_7"
/note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
(poxvirus and zinc finger) domain found in Kelch repeat
and BTB domain-containing proteins KBTBD6 and KBTBD7;
cd18273"
/db_xref="CDD:349582"
Region 55..544
/region_name="PHA03098"
/note="kelch-like protein; Provisional"
/db_xref="CDD:222983"
Region 168..270
/region_name="BACK_KBTBD6_7"
/note="BACK (BTB and C-terminal Kelch) domain found in
Kelch repeat and BTB domain-containing proteins, KBTBD6
and KBTBD7; cd18482"
/db_xref="CDD:350557"
Region 384..421
/region_name="KELCH repeat"
/note="KELCH repeat [structural motif]"
/db_xref="CDD:276965"
Region 386..435
/region_name="Kelch 1"
/note="propagated from UniProtKB/Swiss-Prot (Q8WVZ9.1)"
Region 425..471
/region_name="KELCH repeat"
/note="KELCH repeat [structural motif]"
/db_xref="CDD:276965"
Region 436..484
/region_name="Kelch 2"
/note="propagated from UniProtKB/Swiss-Prot (Q8WVZ9.1)"
Region 474..511
/region_name="KELCH repeat"
/note="KELCH repeat [structural motif]"
/db_xref="CDD:276965"
Region 486..523
/region_name="Kelch 3"
/note="propagated from UniProtKB/Swiss-Prot (Q8WVZ9.1)"
Region 512..551
/region_name="KELCH repeat"
/note="KELCH repeat [structural motif]"
/db_xref="CDD:276965"
Region 524..564
/region_name="Kelch 4"
/note="propagated from UniProtKB/Swiss-Prot (Q8WVZ9.1)"
Region 567..616
/region_name="Kelch 5"
/note="propagated from UniProtKB/Swiss-Prot (Q8WVZ9.1)"
Region 630..666
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q8WVZ9.1)"
Region 668..671
/region_name="ATG8 interaction motif (AIM).
/evidence=ECO:0000269|PubMed:25684205"
/note="propagated from UniProtKB/Swiss-Prot (Q8WVZ9.1)"
CDS 1..684
/gene="KBTBD7"
/coded_by="NM_032138.7:313..2367"
/db_xref="CCDS:CCDS9377.1"
/db_xref="GeneID:84078"
/db_xref="HGNC:HGNC:25266"
/db_xref="MIM:617739"
ORIGIN
1 mqsredvprs rrlasprggr rpkriskpsv safftgpeel kdtahsaall aqlksfydar
61 llcdvtievv tpgsgpgtgr lfscnrnvla aacpyfksmf tggmyesqqa svtmhdvdae
121 sfevlvdycy tgrvslsean vqrlyaasdm lqleyvreac asflarrldl tnctailkfa
181 dafdhhklrs qaqsyiahnf kqlsrmgsir eetladltla qllavlrlds ldiesertvc
241 hvavqwleaa akergpsaae vfkcvrwmhf teedqdyleg lltkpivkky cldviegalq
301 mrygdllyks lvpvpnssss ssssnslvsa aenppqrlgm cakemviffg hprdpflcyd
361 pysgdiytmp spltsfahtk tvtssavcvs pdhdiylaaq prkdlwvykp aqnswqqlad
421 rllcregmdv aylngyiyil ggrdpitgvk lkevecysvq rnqwalvapv phsfysfeli
481 vvqnylyavn skrmlcydps hnmwlncasl krsdfqeacv fndeiycicd ipvmkvynpa
541 rgewrrisni pldsethnyq ivnhdqklll itsttpqwkk nrvtvyeydt redqwinigt
601 mlgllqfdsg ficlcarvyp sclepgqsfi teeddarses stewdldgfs eldsesgsss
661 sfsddevwvq vapqrnaqdq qgsl
//