LOCUS AAI52420 498 aa linear PRI 23-AUG-2007
DEFINITION Angiopoietin 1 [Homo sapiens].
ACCESSION AAI52420
VERSION AAI52420.1
DBSOURCE accession BC152419.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 498)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (residues 1 to 498)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (21-AUG-2007) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Kazusa DNA Research Inst.
cDNA Library Preparation: Kazusa DNA Research Institute
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Sequencing Group at the Stanford Human Genome
Center, Stanford University School of Medicine, Stanford, CA 94305
Web site: http://www-shgc.stanford.edu
Contact: (Dickson, Mark) mcd@paxil.stanford.edu
Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
R. M.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRCF Plate: 15 Row: b Column: 11.
Method: conceptual translation.
FEATURES Location/Qualifiers
source 1..498
/organism="Homo sapiens"
/db_xref="taxon:9606"
/clone="MGC:176650 IMAGE:8862529"
/tissue_type="Clones donated by Kazusa DNA Research Inst."
/clone_lib="Kazusa-KIAA-pBluescriptIISK+"
/lab_host="DH5alpha T1-resistant"
/note="Vector: pBluescript II SK+; Clone identification
sequence tag: NA"
Protein 1..498
/product="angiopoietin 1"
Region <105..>258
/region_name="Mplasa_alph_rch"
/note="helix-rich Mycoplasma protein; TIGR04523"
/db_xref="CDD:275316"
Region 281..496
/region_name="FReD"
/note="Fibrinogen-related domains (FReDs); C terminal
globular domain of fibrinogen. Fibrinogen is involved in
blood clotting, being activated by thrombin to assemble
into fibrin clots. The N-termini of 2 times 3 chains come
together to form a globular...; cd00087"
/db_xref="CDD:238040"
Site 402
/site_type="other"
/note="gamma-gamma dimer interface [polypeptide binding]"
/db_xref="CDD:238040"
Site order(431,433,435)
/site_type="other"
/note="Ca2+ binding site [ion binding]"
/db_xref="CDD:238040"
Site order(439,442..443,452..453)
/site_type="active"
/note="polymerization pocket [active]"
/db_xref="CDD:238040"
CDS 1..498
/gene="ANGPT1"
/gene_synonym="AGP1"
/gene_synonym="AGPT"
/gene_synonym="ANG1"
/coded_by="BC152419.1:364..1860"
/db_xref="GeneID:284"
/db_xref="HGNC:HGNC:484"
/db_xref="MIM:601667"
ORIGIN
1 mtvflsfafl aailthigcs nqrrspensg rrynriqhgq caytfilpeh dgncresttd
61 qyntnalqrd aphvepdfss qklqhlehvm enytqwlqkl enyivenmks emaqiqqnav
121 qnhtatmlei gtsllsqtae qtrkltdvet qvlnqtsrle iqllenslst yklekqllqq
181 tneilkihek nsllehkile megkhkeeld tlkeekenlq glvtrqtyii qelekqlnra
241 ttnnsvlqkq qlelmdtvhn lvnlctkegv llkggkreee kpfrdcadvy qagfnksgiy
301 tiyinnmpep kkvfcnmdvn gggwtviqhr edgsldfqrg wkeykmgfgn psgeywlgne
361 fifaitsqrq ymlrielmdw egnraysqyd rfhignekqn yrlylkghtg tagkqsslil
421 hgadfstkda dndncmckca lmltggwwfd acgpsnlngm fytagqnhgk lngikwhyfk
481 gpsyslrstt mmirpldf
//