RecName: Full=E3 ubiquitin-protein ligase HACE1; AltName: Full=HECT do - Protein

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HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo. [Hum Mol Genet. 2018]
HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo.
Ehrnhoefer DE, Southwell AL, Sivasubramanian M, Qiu X, Villanueva EB, Xie Y, Waltl S, Anderson L, Fazeli A, Casal L, et al. Hum Mol Genet. 2018 Jan 15; 27(2):239-253.
Loss of the tumor suppressor Hace1 leads to ROS-dependent glutamine addiction. [Oncogene. 2015]
Loss of the tumor suppressor Hace1 leads to ROS-dependent glutamine addiction.
Cetinbas N, Daugaard M, Mullen AR, Hajee S, Rotblat B, Lopez A, Li A, DeBerardinis RJ, Sorensen PH. Oncogene. 2015 Jul 23; 34(30):4005-10. Epub 2014 Oct 6.
The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes. [EMBO Rep. 2023]
The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes.
Turgu B, El-Naggar A, Kogler M, Tortola L, Zhang HF, Hassan M, Lizardo MM, Kung SH, Lam W, Penninger JM, et al. EMBO Rep. 2023 Dec 6; 24(12):e56815. Epub 2023 Oct 17.

RefSeq protein isoforms
See 12 reference sequence protein isoforms for the Hace1 gene.

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Mouse Genome Informatics (MGI) [Mouse Genome Informatics (MGI)]
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RecName: Full=E3 ubiquitin-protein ligase HACE1; AltName: Full=HECT domain and a...
RecName: Full=E3 ubiquitin-protein ligase HACE1; AltName: Full=HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1; AltName: Full=HECT-type E3 ubiquitin transferase HACE1
gi|123796888|sp|Q3U0D9.1|HACE1_MOUS

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