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Ago2 argonaute RISC catalytic component 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 59117, updated on 4-Jan-2025

Summary

Official Symbol
Ago2provided by RGD
Official Full Name
argonaute RISC catalytic component 2provided by RGD
Primary source
RGD:621255
See related
EnsemblRapid:ENSRNOG00000008533 AllianceGenome:RGD:621255
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Eif2c2; eIF2C 2
Summary
Enables Hsp70 protein binding activity; Hsp90 protein binding activity; and RISC complex binding activity. Involved in several processes, including regulation of macromolecule biosynthetic process; response to cocaine; and response to morphine. Located in several cellular components, including Golgi apparatus; cytoplasmic ribonucleoprotein granule; and dendrite. Part of RISC complex. Biomarker of morphine dependence and withdrawal disorder. Human ortholog(s) of this gene implicated in alcohol dependence and glaucoma. Orthologous to human AGO2 (argonaute RISC catalytic component 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 251.5), Muscle (RPKM 174.4) and 9 other tissues See more
Orthologs
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Genomic context

See Ago2 in Genome Data Viewer
Location:
7q34
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (106907209..106994124, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (105018202..105105118, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (114339607..114377277, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene trafficking protein particle complex subunit 9 Neighboring gene uncharacterized LOC134479749 Neighboring gene uncharacterized LOC134479922 Neighboring gene chromatin accessibility complex subunit 1 Neighboring gene protein tyrosine kinase 2 Neighboring gene microRNA 151b Neighboring gene uncharacterized LOC134479923 Neighboring gene microRNA 151

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Items 1 - 25 of 40
Function Evidence Code Pubs
enables Hsp70 protein binding PubMed 
enables Hsp90 protein binding PubMed 
enables RISC complex binding PubMed 
enables RNA 7-methylguanosine cap binding  
enables RNA 7-methylguanosine cap binding  
enables RNA 7-methylguanosine cap binding  
enables RNA binding  
enables RNA binding  
enables RNA endonuclease activity  
enables RNA endonuclease activity  
enables RNA polymerase II complex binding  
enables RNA polymerase II complex binding  
enables core promoter sequence-specific DNA binding  
enables core promoter sequence-specific DNA binding  
enables double-stranded RNA binding  
enables double-stranded RNA binding  
enables endoribonuclease activity, cleaving miRNA-paired mRNA  
enables endoribonuclease activity, cleaving miRNA-paired mRNA  
enables endoribonuclease activity, cleaving siRNA-paired mRNA  
enables endoribonuclease activity, cleaving siRNA-paired mRNA  
enables endoribonuclease activity, cleaving siRNA-paired mRNA  
enables hydrolase activity  
enables mRNA 3'-UTR AU-rich region binding  
enables mRNA 3'-UTR AU-rich region binding  
enables mRNA binding  
enables mRNA cap binding  
enables mRNA cap binding  
enables mRNA cap binding  
enables metal ion binding  
enables miRNA binding  
enables miRNA binding  
enables miRNA binding  
enables protein binding PubMed 
enables siRNA binding  
contributes_to siRNA binding  
enables siRNA binding  
enables siRNA binding  
enables single-stranded RNA binding  
enables single-stranded RNA binding  
enables single-stranded RNA binding  
Items 1 - 25 of 40
Items 1 - 25 of 61
Process Evidence Code Pubs
involved_in P-body assembly  
involved_in P-body assembly  
involved_in RISC complex assembly  
involved_in RISC complex assembly  
involved_in RNA secondary structure unwinding  
involved_in RNA secondary structure unwinding  
involved_in cell differentiation PubMed 
involved_in cellular response to calcium ion PubMed 
involved_in miRNA metabolic process  
acts_upstream_of_or_within miRNA metabolic process  
acts_upstream_of_or_within miRNA processing  
involved_in miRNA processing  
involved_in miRNA-mediated gene silencing by inhibition of translation  
involved_in miRNA-mediated gene silencing by inhibition of translation  
involved_in miRNA-mediated gene silencing by inhibition of translation  
involved_in miRNA-mediated gene silencing by mRNA destabilization  
involved_in miRNA-mediated gene silencing by mRNA destabilization  
involved_in miRNA-mediated gene silencing by mRNA destabilization  
involved_in negative regulation of amyloid precursor protein biosynthetic process PubMed 
involved_in negative regulation of translational initiation  
involved_in negative regulation of translational initiation  
involved_in negative regulation of translational initiation  
involved_in positive regulation of angiogenesis  
involved_in positive regulation of angiogenesis  
acts_upstream_of_or_within positive regulation of gene expression  
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening  
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening  
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening  
involved_in positive regulation of post-transcriptional gene silencing by RNA PubMed 
involved_in positive regulation of transcription by RNA polymerase II  
involved_in positive regulation of transcription by RNA polymerase II  
involved_in positive regulation of translation  
involved_in positive regulation of translation  
involved_in positive regulation of trophoblast cell migration  
involved_in positive regulation of trophoblast cell migration  
involved_in post-embryonic development  
acts_upstream_of_or_within post-embryonic development  
involved_in pre-miRNA processing  
involved_in pre-miRNA processing  
involved_in pre-miRNA processing  
involved_in pre-miRNA processing  
involved_in regulation of DNA-templated transcription  
involved_in regulation of mRNA stability PubMed 
involved_in regulation of synapse maturation  
involved_in regulation of synapse maturation  
involved_in regulation of translation  
involved_in regulatory ncRNA-mediated gene silencing  
involved_in regulatory ncRNA-mediated gene silencing  
involved_in regulatory ncRNA-mediated gene silencing  
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing  
involved_in response to cocaine PubMed 
involved_in response to hypoxia PubMed 
involved_in response to morphine PubMed 
involved_in siRNA processing  
involved_in siRNA processing  
involved_in siRNA-mediated gene silencing by mRNA destabilization  
involved_in siRNA-mediated gene silencing by mRNA destabilization  
involved_in spermatogenesis PubMed 
Items 1 - 25 of 61
Items 1 - 20 of 41
Component Evidence Code Pubs
located_in Golgi apparatus PubMed 
located_in P granule PubMed 
located_in P-body  
located_in P-body  
part_of RISC complex  
part_of RISC complex PubMed 
part_of RISC complex  
part_of RISC complex  
part_of RISC complex  
part_of RISC-loading complex  
part_of RISC-loading complex  
part_of RISC-loading complex  
located_in chromatoid body PubMed 
is_active_in cytoplasm  
located_in cytoplasm PubMed 
located_in cytoplasm  
located_in cytoplasm  
is_active_in cytoplasmic ribonucleoprotein granule  
located_in cytoplasmic ribonucleoprotein granule  
located_in cytoplasmic stress granule PubMed 
located_in cytosol PubMed 
located_in cytosol  
located_in cytosol  
located_in cytosol  
located_in dendrite PubMed 
located_in dendrite  
located_in dendrite  
located_in extracellular exosome  
located_in extracellular exosome  
located_in glutamatergic synapse  
is_active_in glutamatergic synapse  
located_in membrane PubMed 
located_in mitochondrion PubMed 
is_active_in nucleus  
located_in nucleus  
located_in nucleus  
located_in pi-body PubMed 
located_in postsynapse  
is_active_in postsynapse  
part_of ribonucleoprotein complex PubMed 
part_of ribonucleoprotein complex  
Items 1 - 20 of 41

General protein information

Preferred Names
protein argonaute-2
Names
argonaute 2, RISC catalytic component
argonaute2
eukaryotic translation initiation factor 2C 2
golgi ER protein 95 kDa
NP_001395847.1
XP_038936149.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001408918.2NP_001395847.1  protein argonaute-2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    Q9QZ81
    UniProtKB/TrEMBL
    F1LRP7
    Related
    ENSRNOP00000011898.4, ENSRNOT00000011898.6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    106907209..106994124 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039080221.2XP_038936149.1  protein argonaute-2 isoform X1

    UniProtKB/Swiss-Prot
    Q9QZ81
    Related
    ENSRNOP00000095405.2, ENSRNOT00000120018.2
    Conserved Domains (4) summary
    cd02846
    Location:181301
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    cd04657
    Location:346771
    Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
    pfam08699
    Location:130180
    ArgoL1; Argonaute linker 1 domain
    pfam16486
    Location:46120
    ArgoN; N-terminal domain of argonaute

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