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Stk3 serine/threonine kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 56274, updated on 28-Jan-2025

Summary

Official Symbol
Stk3provided by MGI
Official Full Name
serine/threonine kinase 3provided by MGI
Primary source
MGI:MGI:1928487
See related
Ensembl:ENSMUSG00000022329 AllianceGenome:MGI:1928487
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MST; Mst2; Mst3; Ste20; mess1; 0610042I06Rik
Summary
Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and transcription regulator activator activity. Involved in hippo signaling. Acts upstream of or within several processes, including chordate embryonic development; hepatocyte apoptotic process; and regulation of signal transduction. Located in cytoplasm. Is expressed in female associated reproductive structure; lung; male associated reproductive structure; and renal vasculature. Orthologous to human STK3 (serine/threonine kinase 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in placenta adult (RPKM 3.7), liver E14 (RPKM 3.7) and 24 other tissues See more
Orthologs
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Genomic context

See Stk3 in Genome Data Viewer
Location:
15 B3.1; 15 14.34 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (34875645..35155990, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (34875499..35155882, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32970 Neighboring gene predicted gene, 53875 Neighboring gene STARR-seq mESC enhancer starr_38332 Neighboring gene STARR-seq mESC enhancer starr_38333 Neighboring gene STARR-seq mESC enhancer starr_38334 Neighboring gene STARR-seq mESC enhancer starr_38335 Neighboring gene K+ voltage-gated channel, subfamily S, 2 Neighboring gene STARR-seq mESC enhancer starr_38336 Neighboring gene predicted gene, 52204 Neighboring gene STARR-seq mESC enhancer starr_38337 Neighboring gene STARR-seq mESC enhancer starr_38338 Neighboring gene predicted gene, 52178 Neighboring gene predicted gene, 33497 Neighboring gene STARR-seq mESC enhancer starr_38340 Neighboring gene odd-skipped related 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (7) 
  • Targeted (7)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Items 1 - 25 of 34
Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity  
enables AMP-activated protein kinase activity  
enables ATP binding  
enables ATP binding  
enables DNA-dependent protein kinase activity  
enables Rho-dependent protein serine/threonine kinase activity  
enables eukaryotic translation initiation factor 2alpha kinase activity  
enables histone H2AS1 kinase activity  
enables histone H2AS121 kinase activity  
enables histone H2AT120 kinase activity  
enables histone H2AXS139 kinase activity  
enables histone H2BS14 kinase activity  
enables histone H2BS36 kinase activity  
enables histone H3S10 kinase activity  
enables histone H3S28 kinase activity  
enables histone H3S57 kinase activity  
enables histone H3T11 kinase activity  
enables histone H3T3 kinase activity  
enables histone H3T45 kinase activity  
enables histone H3T6 kinase activity  
enables histone H4S1 kinase activity  
enables identical protein binding  
enables identical protein binding  
enables magnesium ion binding  
enables magnesium ion binding  
enables protein binding PubMed 
enables protein kinase activity  
enables protein kinase activity  
enables protein serine kinase activity  
enables protein serine/threonine kinase activity  
enables protein serine/threonine kinase activity  
enables protein serine/threonine kinase activity  
enables ribosomal protein S6 kinase activity  
enables transcription regulator activator activity  
Items 1 - 25 of 34
Items 1 - 25 of 45
Process Evidence Code Pubs
acts_upstream_of JNK cascade PubMed 
acts_upstream_of apoptotic process PubMed 
acts_upstream_of canonical Wnt signaling pathway PubMed 
acts_upstream_of_or_within cell differentiation involved in embryonic placenta development PubMed 
acts_upstream_of cell population proliferation PubMed 
acts_upstream_of_or_within central nervous system development PubMed 
involved_in chromatin remodeling  
acts_upstream_of_or_within endocardium development PubMed 
acts_upstream_of epithelial cell proliferation PubMed 
acts_upstream_of extrinsic apoptotic signaling pathway via death domain receptors PubMed 
acts_upstream_of_or_within hepatocyte apoptotic process PubMed 
involved_in hippo signaling PubMed 
involved_in hippo signaling  
involved_in hippo signaling  
involved_in intracellular signal transduction  
involved_in intracellular signal transduction  
involved_in intracellular signal transduction  
involved_in negative regulation of canonical Wnt signaling pathway  
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway PubMed 
involved_in negative regulation of canonical Wnt signaling pathway  
acts_upstream_of_or_within negative regulation of cell population proliferation PubMed 
acts_upstream_of_or_within negative regulation of epithelial cell proliferation PubMed 
acts_upstream_of_or_within negative regulation of organ growth PubMed 
acts_upstream_of_or_within neural tube formation PubMed 
acts_upstream_of organ growth PubMed 
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
acts_upstream_of_or_within positive regulation of JNK cascade PubMed 
involved_in positive regulation of apoptotic process  
acts_upstream_of_or_within positive regulation of apoptotic process PubMed 
involved_in positive regulation of apoptotic process  
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors PubMed 
acts_upstream_of_or_within positive regulation of fat cell differentiation PubMed 
acts_upstream_of_or_within positive regulation of hippo signaling  
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
acts_upstream_of_or_within primitive hemopoiesis PubMed 
involved_in protein import into nucleus  
involved_in protein import into nucleus  
involved_in protein localization to centrosome  
involved_in protein localization to centrosome  
involved_in protein phosphorylation  
acts_upstream_of_or_within protein stabilization  
involved_in protein tetramerization  
involved_in regulation of MAPK cascade  
acts_upstream_of_or_within regulation of cell differentiation involved in embryonic placenta development PubMed 
involved_in regulation of gene expression  
Items 1 - 25 of 45
Component Evidence Code Pubs
located_in centrosome  
is_active_in centrosome  
is_active_in cytoplasm  
located_in cytoplasm PubMed 
is_active_in cytoplasm  
located_in cytoplasm  
located_in nucleus  
located_in nucleus  
part_of protein-containing complex PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase 3
Names
MST-2
STE20-like kinase MST2
mammalian STE20-like protein kinase 2
protein kinase homolog
NP_001344750.1
NP_062609.2
XP_006520182.1
XP_030104530.1
XP_030104531.1
XP_036015421.1
XP_036015422.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357821.1NP_001344750.1  serine/threonine-protein kinase 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC116950, AC122907
    UniProtKB/TrEMBL
    A0A2I3BQE0
    Conserved Domains (2) summary
    cd06612
    Location:1205
    STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
    pfam11629
    Location:370417
    Mst1_SARAH; C terminal SARAH domain of Mst1
  2. NM_019635.2NP_062609.2  serine/threonine-protein kinase 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AY058922, BC049123, BY783841, U28726
    Consensus CDS
    CCDS37059.1
    UniProtKB/Swiss-Prot
    Q60877, Q80UG4, Q8CI58, Q9JI10
    UniProtKB/TrEMBL
    A0A2I3BQE0
    Related
    ENSMUSP00000018476.8, ENSMUST00000018476.14
    Conserved Domains (2) summary
    cd06612
    Location:23278
    STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
    pfam11629
    Location:443490
    Mst1_SARAH; C terminal SARAH domain of Mst1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    34875645..35155990 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248670.2XP_030104530.1  serine/threonine-protein kinase 3 isoform X2

    UniProtKB/TrEMBL
    A0A2I3BQE0
    Related
    ENSMUSP00000064225.8, ENSMUST00000067033.8
    Conserved Domains (2) summary
    pfam11629
    Location:345392
    Mst1_SARAH; C terminal SARAH domain of Mst1
    cl21453
    Location:1180
    PKc_like; Protein Kinases, catalytic domain
  2. XM_036159528.1XP_036015421.1  serine/threonine-protein kinase 3 isoform X2

    UniProtKB/TrEMBL
    A0A2I3BQE0
    Conserved Domains (2) summary
    pfam11629
    Location:345392
    Mst1_SARAH; C terminal SARAH domain of Mst1
    cl21453
    Location:1180
    PKc_like; Protein Kinases, catalytic domain
  3. XM_030248671.2XP_030104531.1  serine/threonine-protein kinase 3 isoform X3

    UniProtKB/TrEMBL
    Q9CW82
    Conserved Domains (2) summary
    pfam11629
    Location:304351
    Mst1_SARAH; C terminal SARAH domain of Mst1
    cl21453
    Location:1139
    PKc_like; Protein Kinases, catalytic domain
  4. XM_036159529.1XP_036015422.1  serine/threonine-protein kinase 3 isoform X3

    UniProtKB/TrEMBL
    Q9CW82
    Conserved Domains (2) summary
    pfam11629
    Location:304351
    Mst1_SARAH; C terminal SARAH domain of Mst1
    cl21453
    Location:1139
    PKc_like; Protein Kinases, catalytic domain
  5. XM_006520119.5XP_006520182.1  serine/threonine-protein kinase 3 isoform X1

    UniProtKB/TrEMBL
    A0A2I3BQE0
    Conserved Domains (1) summary
    cd06612
    Location:23278
    STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
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