U.S. flag

An official website of the United States government

Abo3 histo-blood group ABO system transferase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 65270, updated on 4-Jan-2025

Summary

Official Symbol
Abo3provided by RGD
Official Full Name
histo-blood group ABO system transferase 3provided by RGD
Primary source
RGD:628609
See related
EnsemblRapid:ENSRNOG00000039906 AllianceGenome:RGD:628609
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Abo; Abol1
Summary
Enables glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity. Involved in defense response to bacterium. Predicted to be located in Golgi cisterna membrane and extracellular region. Predicted to be active in Golgi apparatus and vesicle. Human ortholog(s) of this gene implicated in several diseases, including Plasmodium falciparum malaria; graft-versus-host disease; leukemia (multiple); lung disease (multiple); and severe acute respiratory syndrome. Orthologous to human ABO (ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 4.9), Heart (RPKM 3.3) and 9 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Abo3 in Genome Data Viewer
Location:
3p13
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (30141941..30159129)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (9743861..9761049)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (5109880..5127376)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene vomeronasal secretory protein 2-like Neighboring gene glutamic-oxaloacetic transaminase 2, pseudogene 5 Neighboring gene lipocalin 4 Neighboring gene uncharacterized LOC134486061

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

General gene information

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in carbohydrate metabolic process  
involved_in defense response to bacterium PubMed 
involved_in lipid glycosylation  
involved_in protein glycosylation  
Component Evidence Code Pubs
is_active_in Golgi apparatus  
located_in Golgi cisterna membrane  
located_in extracellular region  
located_in membrane  
is_active_in vesicle  

General protein information

Preferred Names
histo-blood group ABO system transferase 1
Names
ABO blood group (alpha 1-3-N-acetylgalactosaminyltransferase, alpha 1-3-galactosyltransferase)
ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase
ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ABO blood group (transferase B, alpha 1-3-galactosyltransferase)
ABO blood group-like 1
B blood group galactosyltransferase
N-acetylgalactosaminyltransferase A blood group-like enzyme
NAGAT 1
a transferase
alpha 1-3-N-acetylgalactosaminyltransferase-like 1
b transferase
blood group A glycosyltransferase 1
cis-AB transferase 1
fucosylglycoprotein 3-alpha-galactosyltransferase
fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase
glycoprotein-fucosylgalactoside alpha-galactosyltransferase
histo-blood group A transferase
histo-blood group B transferase
transferase B, alpha 1-3-galactosyltransferase)
NP_075582.3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023094.4 → NP_075582.3  histo-blood group ABO system transferase 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q8CFC5, Q8CFC6, Q8R005, Q8R4Y3, Q8R552, Q9ET32
    UniProtKB/TrEMBL
    A0A0H2UI32
    Related
    ENSRNOP00000006553.7, ENSRNOT00000006553.9
    Conserved Domains (1) summary
    pfam03414
    Location:59 → 348
    Glyco_transf_6; Glycosyltransferase family 6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    30141941..30159129
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
External link. Please review our privacy policy.