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Clcn2 chloride voltage-gated channel 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29232, updated on 4-Jan-2025

Summary

Symbol
Clcn2provided by RGD
Full Name
chloride voltage-gated channel 2provided by RGD
Primary source
RGD:2361
See related
EnsemblRapid:ENSRNOG00000001742 AllianceGenome:RGD:2361
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ClC-2
Summary
Enables voltage-gated chloride channel activity and volume-sensitive chloride channel activity. Involved in several processes, including cellular hypotonic response; positive regulation of oligodendrocyte differentiation; and positive regulation of voltage-gated chloride channel activity. Located in several cellular components, including axon initial segment; dendritic spine membrane; and perikaryon. Used to study cystic fibrosis. Human ortholog(s) of this gene implicated in idiopathic generalized epilepsy 11 and primary hyperaldosteronism. Orthologous to human CLCN2 (chloride voltage-gated channel 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 54.8), Brain (RPKM 54.0) and 9 other tissues See more
Orthologs
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Genomic context

See Clcn2 in Genome Data Viewer
Location:
11q23
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (93702382..93716059)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (80197741..80211657)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (82862664..82876165)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene thrombopoietin like 1 Neighboring gene RNA polymerase II, I and III subunit H Neighboring gene family with sequence similarity 131, member A Neighboring gene eukaryotic translation initiation factor 4 gamma 1 Neighboring gene small nucleolar RNA, C/D box 66 Neighboring gene proteasome 26S subunit ubiquitin receptor, non-ATPase 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within acinar cell differentiation  
acts_upstream_of_or_within cell differentiation involved in salivary gland development  
involved_in cellular hypotonic response PubMed 
involved_in chloride transmembrane transport  
involved_in chloride transport  
involved_in chloride transport PubMed 
involved_in chloride transport  
involved_in lung development PubMed 
involved_in phagocytosis, engulfment  
involved_in positive regulation of oligodendrocyte differentiation PubMed 
involved_in positive regulation of voltage-gated chloride channel activity PubMed 
involved_in regulation of aldosterone biosynthetic process  
involved_in regulation of aldosterone biosynthetic process  
involved_in regulation of membrane depolarization during action potential PubMed 
involved_in regulation of resting membrane potential  
involved_in regulation of resting membrane potential  
acts_upstream_of_or_within retina development in camera-type eye  
involved_in stabilization of membrane potential  
involved_in stabilization of membrane potential  
Component Evidence Code Pubs
located_in actin cytoskeleton  
located_in astrocyte end-foot PubMed 
located_in astrocyte end-foot  
located_in axon  
located_in axon initial segment PubMed 
located_in basolateral plasma membrane  
located_in basolateral plasma membrane  
part_of chloride channel complex  
located_in dendrite PubMed 
located_in dendritic spine membrane PubMed 
located_in dendritic spine membrane  
located_in myelin sheath  
located_in perikaryon PubMed 
is_active_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane  
located_in postsynaptic membrane  

General protein information

Preferred Names
chloride channel protein 2
Names
chloride channel 2
chloride channel, voltage-sensitive 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017137.2NP_058833.1  chloride channel protein 2

    See identical proteins and their annotated locations for NP_058833.1

    Status: VALIDATED

    Source sequence(s)
    X64139
    UniProtKB/Swiss-Prot
    P35525
    UniProtKB/TrEMBL
    A6JS86, O54821
    Related
    ENSRNOP00000050925.3, ENSRNOT00000050927.8
    Conserved Domains (3) summary
    cd03683
    Location:96573
    ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
    cd04591
    Location:799847
    CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
    pfam00654
    Location:149552
    Voltage_CLC; Voltage gated chloride channel

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    93702382..93716059
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006248563.5XP_006248625.1  chloride channel protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006248625.1

    UniProtKB/TrEMBL
    A0A0A0MXT6, O54822
    Related
    ENSRNOP00000002376.5, ENSRNOT00000002376.10
    Conserved Domains (3) summary
    cd03683
    Location:96573
    ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
    cd04591
    Location:779827
    CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
    pfam00654
    Location:149552
    Voltage_CLC; Voltage gated chloride channel
  2. XM_039088239.2XP_038944167.1  chloride channel protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8L2QXG3
    Conserved Domains (2) summary
    cd03683
    Location:1446
    ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
    cd04591
    Location:458720
    CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria
  3. XM_063270438.1XP_063126508.1  chloride channel protein 2 isoform X4

  4. XM_063270437.1XP_063126507.1  chloride channel protein 2 isoform X3

  5. XM_039088243.2XP_038944171.1  chloride channel protein 2 isoform X6

    UniProtKB/TrEMBL
    O54823
    Conserved Domains (1) summary
    cd03683
    Location:96471
    ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
  6. XM_039088240.2XP_038944168.1  chloride channel protein 2 isoform X5

    Conserved Domains (2) summary
    cl02915
    Location:15309
    Voltage_gated_ClC; CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This ...
    cd04591
    Location:321583
    CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria
  7. XM_039088244.2XP_038944172.1  chloride channel protein 2 isoform X7

    Conserved Domains (2) summary
    cl02915
    Location:43144
    Voltage_gated_ClC; CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This ...
    cd04591
    Location:156418
    CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria

RNA

  1. XR_595157.4 RNA Sequence

  2. XR_358402.5 RNA Sequence

  3. XR_595156.4 RNA Sequence

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