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    Rasgrp1 RAS guanyl releasing protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 19419, updated on 4-Jan-2025

    Summary

    Official Symbol
    Rasgrp1provided by MGI
    Official Full Name
    RAS guanyl releasing protein 1provided by MGI
    Primary source
    MGI:MGI:1314635
    See related
    Ensembl:ENSMUSG00000027347 AllianceGenome:MGI:1314635
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rasgrp; calDAG-GEFII
    Summary
    Predicted to enable several functions, including cation binding activity; diacylglycerol binding activity; and guanyl-nucleotide exchange factor activity. Involved in activation of GTPase activity; positive regulation of T cell differentiation in thymus; and positive regulation of natural killer cell differentiation. Acts upstream of or within several processes, including mast cell degranulation; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and vesicle transport along microtubule. Predicted to be located in Golgi apparatus and cytosol. Predicted to be active in plasma membrane. Is expressed in several structures, including brain and olfactory epithelium. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in immunodeficiency 64. Orthologous to human RASGRP1 (RAS guanyl releasing protein 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in frontal lobe adult (RPKM 49.5), cortex adult (RPKM 48.8) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Rasgrp1 in Genome Data Viewer
    Location:
    2 E5; 2 59.19 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (117110464..117173358, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (117279983..117342877, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2635 Neighboring gene predicted gene, 25189 Neighboring gene family with sequence similarity 98, member B Neighboring gene STARR-positive B cell enhancer mm9_chr2:117129704-117130005 Neighboring gene STARR-seq mESC enhancer starr_05451 Neighboring gene STARR-positive B cell enhancer ABC_E3392 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:117168575-117168758 Neighboring gene predicted gene, 32020 Neighboring gene predicted gene 13982

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (7) 
    • Endonuclease-mediated (4) 
    • Spontaneous (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding  
    enables calcium ion binding  
    enables diacylglycerol binding  
    enables diacylglycerol binding  
    enables guanyl-nucleotide exchange factor activity  
    enables guanyl-nucleotide exchange factor activity  
    enables guanyl-nucleotide exchange factor activity  
    enables identical protein binding  
    enables identical protein binding  
    enables phosphatidylcholine binding  
    enables phosphatidylcholine binding  
    enables zinc ion binding  
    enables zinc ion binding  
    Items 1 - 25 of 37
    Process Evidence Code Pubs
    involved_in B cell activation  
    involved_in B cell proliferation  
    involved_in B cell proliferation  
    involved_in Ras protein signal transduction  
    involved_in T cell activation  
    involved_in T cell proliferation  
    involved_in T cell proliferation  
    acts_upstream_of_or_within activation of GTPase activity PubMed 
    involved_in activation of GTPase activity PubMed 
    involved_in activation of GTPase activity  
    involved_in cell differentiation  
    acts_upstream_of_or_within inflammatory response to antigenic stimulus PubMed 
    acts_upstream_of_or_within mast cell cytokine production PubMed 
    acts_upstream_of_or_within mast cell degranulation PubMed 
    involved_in natural killer cell activation  
    involved_in natural killer cell activation  
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of GTPase activity  
    involved_in positive regulation of JNK cascade  
    involved_in positive regulation of MAP kinase activity  
    involved_in positive regulation of Ras protein signal transduction  
    involved_in positive regulation of Ras protein signal transduction  
    involved_in positive regulation of T cell differentiation in thymus PubMed 
    involved_in positive regulation of granulocyte macrophage colony-stimulating factor production  
    involved_in positive regulation of natural killer cell activation PubMed 
    involved_in positive regulation of natural killer cell differentiation PubMed 
    involved_in positive regulation of natural killer cell mediated cytotoxicity  
    involved_in positive regulation of natural killer cell mediated cytotoxicity  
    involved_in positive regulation of protein phosphorylation  
    involved_in positive regulation of tumor necrosis factor production  
    involved_in positive regulation of type II interferon production  
    involved_in regulation of ERK1 and ERK2 cascade  
    involved_in regulation of ERK1 and ERK2 cascade  
    acts_upstream_of_or_within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    acts_upstream_of_or_within secretory granule localization PubMed 
    involved_in small GTPase-mediated signal transduction  
    acts_upstream_of_or_within vesicle transport along microtubule PubMed 
    Items 1 - 25 of 37
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi membrane  
    located_in cytosol  
    located_in cytosol  
    located_in endoplasmic reticulum membrane  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    RAS guanyl-releasing protein 1
    Names
    calcium and DAG-regulated guanine nucleotide exchange factor II

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011246.3NP_035376.1  RAS guanyl-releasing protein 1

      See identical proteins and their annotated locations for NP_035376.1

      Status: VALIDATED

      Source sequence(s)
      BC057341, BE991595
      Consensus CDS
      CCDS16572.1
      UniProtKB/Swiss-Prot
      Q3URH0, Q3V401, Q8BQP6, Q9Z1S3
      UniProtKB/TrEMBL
      G3UYC3
      Related
      ENSMUSP00000099593.5, ENSMUST00000102534.11
      Conserved Domains (5) summary
      smart00147
      Location:201437
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:54176
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00051
      Location:474521
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:542591
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam13499
      Location:478526
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      117110464..117173358 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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