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    Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha [ Mus musculus (house mouse) ]

    Gene ID: 13665, updated on 14-Jan-2025

    Summary

    Official Symbol
    Eif2s1provided by MGI
    Official Full Name
    eukaryotic translation initiation factor 2, subunit 1 alphaprovided by MGI
    Primary source
    MGI:MGI:95299
    See related
    Ensembl:ENSMUSG00000021116 AllianceGenome:MGI:95299
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    35kDa; Eif2a; eIF2alpha; 0910001O23Rik; 2410026C18Rik
    Summary
    Predicted to enable ribosome binding activity and translation initiation factor activity. Involved in several processes, including cellular response to amino acid starvation; negative regulation of translational initiation in response to stress; and stress granule assembly. Acts upstream of or within protein autophosphorylation; regulation of translational initiation in response to stress; and translation. Located in cytoplasmic stress granule and nucleus. Is active in synapse. Is expressed in several structures, including brain ventricular layer; jaw; nose; orbito-sphenoid; and thymus primordium. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in placenta adult (RPKM 24.6), liver E14 (RPKM 23.2) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Eif2s1 in Genome Data Viewer
    Location:
    12 C3; 12 35.51 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (78908846..78933784)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (78862072..78887010)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10759 Neighboring gene protein associated with LIN7 1, MAGUK family member Neighboring gene STARR-seq mESC enhancer starr_32577 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit D Neighboring gene STARR-seq mESC enhancer starr_32578 Neighboring gene pleckstrin 2 Neighboring gene STARR-seq mESC enhancer starr_32580 Neighboring gene predicted gene, 46359 Neighboring gene STARR-seq mESC enhancer starr_32581 Neighboring gene predicted gene, 46360

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding  
    enables protein binding PubMed 
    enables ribosome binding  
    enables ribosome binding  
    enables ribosome binding  
    enables translation initiation factor activity  
    enables translation initiation factor activity  
    enables translation initiation factor activity  
    Items 1 - 25 of 27
    Process Evidence Code Pubs
    involved_in HRI-mediated signaling  
    involved_in HRI-mediated signaling  
    involved_in PERK-mediated unfolded protein response  
    involved_in PERK-mediated unfolded protein response  
    involved_in cellular response to UV PubMed 
    involved_in cellular response to amino acid starvation PubMed 
    involved_in cellular response to heat  
    involved_in cellular response to heat  
    involved_in cellular response to oxidative stress PubMed 
    involved_in mitophagy  
    involved_in mitophagy  
    involved_in negative regulation of translational initiation in response to stress PubMed 
    involved_in positive regulation of type B pancreatic cell apoptotic process  
    involved_in positive regulation of type B pancreatic cell apoptotic process  
    acts_upstream_of_or_within protein autophosphorylation PubMed 
    involved_in regulation of translation in response to endoplasmic reticulum stress  
    involved_in regulation of translation in response to endoplasmic reticulum stress  
    acts_upstream_of_or_within regulation of translational initiation in response to stress PubMed 
    involved_in response to endoplasmic reticulum stress PubMed 
    involved_in response to endoplasmic reticulum stress  
    involved_in response to kainic acid  
    involved_in response to manganese-induced endoplasmic reticulum stress  
    involved_in stress granule assembly PubMed 
    acts_upstream_of_or_within translation PubMed 
    involved_in translational initiation  
    involved_in translational initiation  
    involved_in translational initiation  
    Items 1 - 25 of 27
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    located_in cytoplasmic stress granule PubMed 
    located_in cytosol  
    located_in cytosol  
    part_of eukaryotic 48S preinitiation complex  
    part_of eukaryotic translation initiation factor 2 complex  
    part_of eukaryotic translation initiation factor 2 complex  
    part_of eukaryotic translation initiation factor 2 complex PubMed 
    located_in glial limiting end-foot  
    located_in glial limiting end-foot  
    is_active_in mitochondrion  
    is_active_in mitochondrion  
    located_in nucleus PubMed 
    is_active_in synapse PubMed 
    is_active_in synapse PubMed 
    part_of translation initiation ternary complex  
    part_of translation initiation ternary complex  

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 2 subunit 1
    Names
    eIF-2-alpha
    eIF-2A
    eIF-2alpha
    eIF2-alpha
    eukaryotic translation initiation factor 2 subunit alpha
    eukaryotic translation initiation factor 2A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026114.3NP_080390.1  eukaryotic translation initiation factor 2 subunit 1

      See identical proteins and their annotated locations for NP_080390.1

      Status: PROVISIONAL

      Source sequence(s)
      AK143499
      Consensus CDS
      CCDS26003.1
      UniProtKB/Swiss-Prot
      Q3TIQ0, Q6ZWX6
      Related
      ENSMUSP00000071214.8, ENSMUST00000071230.8
      Conserved Domains (1) summary
      PTZ00248
      Location:4315
      PTZ00248; eukaryotic translation initiation factor 2 subunit 1; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      78908846..78933784
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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