U.S. flag

An official website of the United States government

Calr calreticulin [ Mus musculus (house mouse) ]

Gene ID: 12317, updated on 13-Jan-2025

Summary

Official Symbol
Calrprovided by MGI
Official Full Name
calreticulinprovided by MGI
Primary source
MGI:MGI:88252
See related
Ensembl:ENSMUSG00000003814 AllianceGenome:MGI:88252
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CRT; Calregulin
Summary
Enables calcium ion binding activity; carbohydrate binding activity; and mRNA binding activity. Involved in several processes, including peptide antigen assembly with MHC class I protein complex; positive regulation of phagocytosis; and protein stabilization. Acts upstream of or within cortical actin cytoskeleton organization; positive regulation of non-canonical NF-kappaB signal transduction; and regulation of meiotic nuclear division. Located in endoplasmic reticulum; external side of plasma membrane; and extracellular space. Part of MHC class I peptide loading complex. Is expressed in several structures, including central nervous system; extraembryonic component; gut; placenta; and white fat. Used to study congestive heart failure. Human ortholog(s) of this gene implicated in several diseases, including endocrine gland cancer (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); lung cancer (multiple); and thrombocytosis. Orthologous to human CALR (calreticulin). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in placenta adult (RPKM 574.7), genital fat pad adult (RPKM 279.2) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Calr in Genome Data Viewer
Location:
8 C3; 8 41.21 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (85568717..85573560, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (84842088..84846931, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene DAN domain family member 5, BMP antagonist Neighboring gene growth arrest and DNA-damage-inducible, gamma interacting protein 1 Neighboring gene RAD23 homolog A, nucleotide excision repair protein Neighboring gene STARR-positive B cell enhancer ABC_E5027 Neighboring gene RIKEN cDNA 1700122E12 gene Neighboring gene STARR-positive B cell enhancer ABC_E564 Neighboring gene predicted gene 5911 Neighboring gene phenylalanyl-tRNA synthetase, alpha subunit Neighboring gene microRNA 7069

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (9)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Items 1 - 25 of 26
Function Evidence Code Pubs
enables calcium ion binding  
enables calcium ion binding PubMed 
enables calcium ion binding  
enables carbohydrate binding PubMed 
enables complement component C1q complex binding  
enables complement component C1q complex binding  
enables hormone binding  
enables hormone binding  
enables integrin binding  
enables integrin binding  
enables iron ion binding  
enables iron ion binding  
enables mRNA binding PubMed 
enables mRNA binding  
enables molecular sequestering activity  
enables molecular sequestering activity  
enables nuclear androgen receptor binding  
enables nuclear androgen receptor binding  
enables nuclear export signal receptor activity  
enables nuclear export signal receptor activity  
enables peptide binding  
enables peptide binding  
enables protein binding PubMed 
enables ubiquitin protein ligase binding  
enables ubiquitin protein ligase binding  
enables unfolded protein binding  
Items 1 - 25 of 26
Items 1 - 25 of 51
Process Evidence Code Pubs
involved_in ERAD pathway  
involved_in cardiac muscle cell differentiation  
involved_in cellular response to electrical stimulus  
involved_in cellular response to lithium ion  
involved_in cellular response to virus  
involved_in cellular senescence PubMed 
involved_in cellular senescence  
acts_upstream_of_or_within cortical actin cytoskeleton organization PubMed 
involved_in negative regulation of DNA-templated transcription  
involved_in negative regulation of intracellular steroid hormone receptor signaling pathway  
involved_in negative regulation of intracellular steroid hormone receptor signaling pathway  
involved_in negative regulation of neuron differentiation  
involved_in negative regulation of neuron differentiation  
involved_in negative regulation of retinoic acid receptor signaling pathway  
involved_in negative regulation of retinoic acid receptor signaling pathway  
involved_in negative regulation of transcription by RNA polymerase II  
involved_in negative regulation of transcription by RNA polymerase II  
involved_in negative regulation of translation  
involved_in negative regulation of translation  
involved_in negative regulation of trophoblast cell migration  
involved_in negative regulation of trophoblast cell migration  
involved_in peptide antigen assembly with MHC class I protein complex PubMed 
involved_in peptide antigen assembly with MHC class I protein complex  
involved_in positive regulation of cell cycle PubMed 
acts_upstream_of positive regulation of cell cycle  
involved_in positive regulation of cell population proliferation  
involved_in positive regulation of cell population proliferation  
involved_in positive regulation of dendritic cell chemotaxis  
involved_in positive regulation of dendritic cell chemotaxis  
involved_in positive regulation of endothelial cell migration  
involved_in positive regulation of endothelial cell migration  
involved_in positive regulation of gene expression PubMed 
acts_upstream_of_or_within positive regulation of non-canonical NF-kappaB signal transduction PubMed 
involved_in positive regulation of phagocytosis PubMed 
involved_in positive regulation of substrate adhesion-dependent cell spreading  
involved_in positive regulation of substrate adhesion-dependent cell spreading  
involved_in protein export from nucleus  
involved_in protein export from nucleus  
involved_in protein folding  
involved_in protein folding  
involved_in protein localization to nucleus PubMed 
involved_in protein localization to nucleus  
involved_in protein stabilization PubMed 
acts_upstream_of_or_within regulation of meiotic nuclear division PubMed 
involved_in response to biphenyl  
involved_in response to estradiol  
involved_in response to glycoside  
involved_in response to peptide  
involved_in response to testosterone  
involved_in response to xenobiotic stimulus  
involved_in spermatogenesis  
Items 1 - 25 of 51
Items 1 - 20 of 39
Component Evidence Code Pubs
part_of MHC class I peptide loading complex PubMed 
part_of MHC class I peptide loading complex  
located_in acrosomal vesicle  
located_in acrosomal vesicle  
located_in cell surface  
located_in collagen-containing extracellular matrix  
located_in collagen-containing extracellular matrix  
located_in cortical granule  
located_in cytolytic granule  
located_in cytoplasm  
located_in cytosol  
located_in cytosol  
located_in endoplasmic reticulum PubMed 
located_in endoplasmic reticulum PubMed 
located_in endoplasmic reticulum PubMed 
located_in endoplasmic reticulum lumen PubMed 
located_in endoplasmic reticulum lumen  
is_active_in endoplasmic reticulum membrane  
located_in endoplasmic reticulum quality control compartment PubMed 
located_in external side of plasma membrane PubMed 
located_in extracellular region  
located_in extracellular space PubMed 
located_in extracellular space  
located_in glutamatergic synapse  
located_in membrane PubMed 
located_in nuclear envelope  
located_in nuclear envelope  
located_in nucleus  
located_in perinuclear region of cytoplasm  
located_in perinuclear region of cytoplasm  
located_in phagocytic vesicle  
located_in postsynapse  
part_of protein-containing complex  
located_in ribosome  
located_in ribosome  
located_in sarcoplasmic reticulum  
located_in sarcoplasmic reticulum lumen  
located_in smooth endoplasmic reticulum  
located_in smooth endoplasmic reticulum  
Items 1 - 20 of 39

General protein information

Preferred Names
calreticulin
Names
CRP55
ERp60
HACBP
endoplasmic reticulum resident protein 60

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007591.3NP_031617.1  calreticulin precursor

    See identical proteins and their annotated locations for NP_031617.1

    Status: VALIDATED

    Source sequence(s)
    AK075605, AK160197, BB727203, BY291864
    Consensus CDS
    CCDS22479.1
    UniProtKB/Swiss-Prot
    P14211, Q3TVD2
    UniProtKB/TrEMBL
    B2MWM9, Q3UWP8
    Related
    ENSMUSP00000003912.7, ENSMUST00000003912.7
    Conserved Domains (1) summary
    pfam00262
    Location:23332
    Calreticulin; Calreticulin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    85568717..85573560 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
External link. Please review our privacy policy.