Replication interactions
Interaction |
Pubs |
Knockdown of adenylate cyclase 1 (ADCY1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells |
PubMed
|
Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Envelope surface glycoprotein gp120
|
env
|
The addition of HIV-1 gp120 with TNF-alpha to human B-cells stimulates cAMP production in a dose-dependent manner |
PubMed
|
Envelope transmembrane glycoprotein gp41
|
env
|
Secretion of IL-10 is upregulated by HIV-1 gp41 in monocytes through activation of cAMP/adenylate cyclase and p70 (S6)-kinase; up-regulation of IL-10 is paralleled by an enhanced expression of the chemokine receptor CCR5 |
PubMed
|
Nef
|
nef
|
HIV-1 induces the upregulation of complement factor C3 in astrocytes and neurons through signaling pathways that involve protein kinase C and adenylate cyclase activation, which is an effect that may contribute to the pathogenesis of AIDS in the brain |
PubMed
|
Tat
|
tat
|
The gene expression of adenylate cyclase 1 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC cells |
PubMed
|
|
tat
|
HIV-1 Tat inhibits adenylyl cyclase activity in microglia and astrocyte cultures from neonatal rat brain, suggesting that Tat inhibition of cAMP synthesis may contribute to neuronal degeneration and cell death associated with HIV infection |
PubMed
|
Go to the HIV-1, Human Interaction Database