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Flt1 FMS-like tyrosine kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 14254, updated on 4-Jan-2025

Summary

Official Symbol
Flt1provided by MGI
Official Full Name
FMS-like tyrosine kinase 1provided by MGI
Primary source
MGI:MGI:95558
See related
Ensembl:ENSMUSG00000029648 AllianceGenome:MGI:95558
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Flt-1; sFlt1; VEGFR1; VEGFR-1
Summary
Enables identical protein binding activity and vascular endothelial growth factor receptor activity. Involved in several processes, including blood vessel morphogenesis; embryonic morphogenesis; and hyaloid vascular plexus regression. Acts upstream of or within several processes, including angiogenesis; positive regulation of hematopoietic progenitor cell differentiation; and post-embryonic camera-type eye morphogenesis. Located in extracellular space and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; extraembryonic component; and genitourinary system. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; bronchopulmonary dysplasia; diabetic retinopathy; and pre-eclampsia. Orthologous to human FLT1 (fms related receptor tyrosine kinase 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in placenta adult (RPKM 35.7), lung adult (RPKM 11.8) and 11 other tissues See more
Orthologs
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Genomic context

See Flt1 in Genome Data Viewer
Location:
5 G3; 5 87.01 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (147498414..147663419, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (147561604..147726438, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8093 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:148238101-148238295 Neighboring gene DNA segment, Chr 5, ERATO Doi 605, expressed Neighboring gene PAN3 poly(A) specific ribonuclease subunit Neighboring gene STARR-positive B cell enhancer ABC_E2773 Neighboring gene predicted gene, 35383 Neighboring gene STARR-seq mESC enhancer starr_14879 Neighboring gene STARR-seq mESC enhancer starr_14882 Neighboring gene predicted gene, 35541 Neighboring gene predicted gene, 35592

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (8)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Items 1 - 25 of 31
Function Evidence Code Pubs
enables ATP binding  
enables ATP binding  
enables GPI-linked ephrin receptor activity  
enables boss receptor activity  
enables brain-derived neurotrophic factor receptor activity  
enables epidermal growth factor receptor activity  
enables fibroblast growth factor receptor activity  
enables growth factor binding  
enables growth factor binding  
enables hepatocyte growth factor receptor activity  
enables histone H2AXY142 kinase activity  
enables histone H3Y41 kinase activity  
enables identical protein binding PubMed 
enables insulin receptor activity  
enables insulin-like growth factor receptor activity  
enables macrophage colony-stimulating factor receptor activity  
enables placental growth factor receptor activity  
enables placental growth factor receptor activity  
enables platelet-derived growth factor alpha-receptor activity  
enables platelet-derived growth factor beta-receptor activity  
enables protein binding PubMed 
enables protein homodimerization activity  
enables protein tyrosine kinase collagen receptor activity  
enables stem cell factor receptor activity  
enables transmembrane receptor protein tyrosine kinase activity  
enables transmembrane-ephrin receptor activity  
enables vascular endothelial growth factor receptor activity  
enables vascular endothelial growth factor receptor activity PubMed 
enables vascular endothelial growth factor receptor activity  
enables vascular endothelial growth factor receptor activity  
enables vascular endothelial growth factor receptor activity  
Items 1 - 25 of 31
Items 1 - 25 of 59
Process Evidence Code Pubs
involved_in Kit signaling pathway  
acts_upstream_of_or_within angiogenesis PubMed 
involved_in angiogenesis PubMed 
involved_in blood vessel morphogenesis PubMed 
involved_in brain-derived neurotrophic factor receptor signaling pathway  
acts_upstream_of_or_within branching involved in blood vessel morphogenesis PubMed 
involved_in cell differentiation  
acts_upstream_of_or_within cell migration PubMed 
involved_in cell migration PubMed 
involved_in cell migration  
involved_in cellular response to vascular endothelial growth factor stimulus  
involved_in chemotaxis  
involved_in chromatin remodeling  
involved_in collagen-activated tyrosine kinase receptor signaling pathway  
involved_in embryonic morphogenesis PubMed 
involved_in ephrin receptor signaling pathway  
involved_in epidermal growth factor receptor signaling pathway  
involved_in fibroblast growth factor receptor signaling pathway  
involved_in hepatocyte growth factor receptor signaling pathway  
involved_in hyaloid vascular plexus regression PubMed 
involved_in insulin receptor signaling pathway  
involved_in insulin-like growth factor receptor signaling pathway  
involved_in intracellular receptor signaling pathway  
involved_in macrophage colony-stimulating factor signaling pathway  
involved_in monocyte chemotaxis  
involved_in multicellular organism development  
involved_in negative regulation of sprouting angiogenesis  
involved_in negative regulation of vascular endothelial cell proliferation  
involved_in negative regulation of vascular endothelial growth factor production  
involved_in peptidyl-tyrosine phosphorylation  
involved_in peptidyl-tyrosine phosphorylation  
involved_in platelet-derived growth factor receptor-alpha signaling pathway  
involved_in platelet-derived growth factor receptor-beta signaling pathway  
involved_in positive regulation of MAP kinase activity  
involved_in positive regulation of MAPK cascade  
involved_in positive regulation of MAPK cascade  
involved_in positive regulation of angiogenesis  
involved_in positive regulation of cell migration  
involved_in positive regulation of cell migration  
involved_in positive regulation of glial cell proliferation  
acts_upstream_of_or_within positive regulation of hematopoietic progenitor cell differentiation PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
involved_in positive regulation of smooth muscle cell proliferation  
acts_upstream_of_or_within post-embryonic camera-type eye morphogenesis PubMed 
involved_in protein autophosphorylation  
involved_in protein autophosphorylation  
involved_in regulation of smooth muscle contraction  
acts_upstream_of_or_within response to hypoxia PubMed 
involved_in response to hypoxia  
involved_in sprouting angiogenesis  
acts_upstream_of_or_within sprouting angiogenesis PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway  
acts_upstream_of_or_within vascular endothelial growth factor receptor signaling pathway PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway  
acts_upstream_of_or_within vascular endothelial growth factor receptor signaling pathway PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway  
involved_in vascular endothelial growth factor receptor-1 signaling pathway  
involved_in vascular endothelial growth factor receptor-1 signaling pathway  
involved_in vascular endothelial growth factor signaling pathway  
Items 1 - 25 of 59
Component Evidence Code Pubs
located_in actin cytoskeleton  
located_in endosome  
located_in extracellular space PubMed 
located_in extracellular space  
located_in nucleus PubMed 
is_active_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane  
part_of receptor complex  
part_of receptor complex PubMed 

General protein information

Preferred Names
vascular endothelial growth factor receptor 1
Names
embryonic receptor kinase 2
tyrosine-protein kinase receptor FLT
vascular permeability factor receptor
NP_001350064.1
NP_034358.2
XP_006504864.1
XP_006504865.1
XP_006504866.1
XP_011239302.1
XP_036020680.1
XP_036020681.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363135.1NP_001350064.1  vascular endothelial growth factor receptor 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC131730, AK013236, AK167497, BP763953
    Consensus CDS
    CCDS90022.1
    UniProtKB/TrEMBL
    O55095, Q3TJC1, Q8K1H4
    Related
    ENSMUSP00000106158.2, ENSMUST00000110529.6
    Conserved Domains (4) summary
    smart00408
    Location:570641
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:144220
    IG; Immunoglobulin
    pfam13927
    Location:428540
    Ig_3; Immunoglobulin domain
    cl11960
    Location:354425
    Ig; Immunoglobulin domain
  2. NM_010228.4NP_034358.2  vascular endothelial growth factor receptor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_034358.2

    Status: VALIDATED

    Source sequence(s)
    AC122299, AC131730
    Consensus CDS
    CCDS19879.1
    UniProtKB/Swiss-Prot
    O55094, P35969, Q61517
    UniProtKB/TrEMBL
    A0A0R4J0A4
    Related
    ENSMUSP00000031653.6, ENSMUST00000031653.12
    Conserved Domains (8) summary
    cd00096
    Location:452550
    Ig; Immunoglobulin domain
    smart00408
    Location:677739
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:570641
    IG; Immunoglobulin
    smart00410
    Location:238329
    IG_like; Immunoglobulin like
    pfam07679
    Location:662749
    I-set; Immunoglobulin I-set domain
    pfam07714
    Location:8281154
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:354425
    Ig; Immunoglobulin domain
    cl21453
    Location:8201157
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    147498414..147663419 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164787.1XP_036020680.1  vascular endothelial growth factor receptor 1 isoform X2

    Conserved Domains (4) summary
    smart00408
    Location:475
    IGc2; Immunoglobulin C-2 Type
    pfam07679
    Location:96183
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:114117
    Ig; Ig strand B [structural motif]
    cl21453
    Location:254591
    PKc_like; Protein Kinases, catalytic domain
  2. XM_011241000.4XP_011239302.1  vascular endothelial growth factor receptor 1 isoform X3

    UniProtKB/TrEMBL
    Q3TJC1, Q8K1H4
    Conserved Domains (5) summary
    smart00408
    Location:570641
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:144220
    IG_like; Immunoglobulin like
    pfam07679
    Location:662749
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:429540
    Ig_3; Immunoglobulin domain
    cl11960
    Location:354425
    Ig; Immunoglobulin domain
  3. XM_006504801.5XP_006504864.1  vascular endothelial growth factor receptor 1 isoform X1

    Conserved Domains (4) summary
    smart00408
    Location:570641
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:144220
    IG; Immunoglobulin
    pfam13927
    Location:429540
    Ig_3; Immunoglobulin domain
    cl11960
    Location:354425
    Ig; Immunoglobulin domain
  4. XM_006504802.5XP_006504865.1  vascular endothelial growth factor receptor 1 isoform X4

    UniProtKB/TrEMBL
    Q3TJC1, Q8K1H4
    Conserved Domains (4) summary
    smart00408
    Location:570641
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:144220
    IG_like; Immunoglobulin like
    pfam13927
    Location:429540
    Ig_3; Immunoglobulin domain
    cl11960
    Location:354425
    Ig; Immunoglobulin domain
  5. XM_006504803.5XP_006504866.1  vascular endothelial growth factor receptor 1 isoform X5

    UniProtKB/TrEMBL
    Q3TJC1, Q8K1H4
    Conserved Domains (4) summary
    smart00408
    Location:570641
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:144220
    IG; Immunoglobulin
    pfam13927
    Location:429540
    Ig_3; Immunoglobulin domain
    cl11960
    Location:354425
    Ig; Immunoglobulin domain
  6. XM_036164788.1XP_036020681.1  vascular endothelial growth factor receptor 1 isoform X6

    UniProtKB/TrEMBL
    Q9DAV2
    Conserved Domains (4) summary
    smart00410
    Location:144220
    IG_like; Immunoglobulin like
    pfam13927
    Location:428468
    Ig_3; Immunoglobulin domain
    cd00096
    Location:334338
    Ig; Ig strand A [structural motif]
    cl11960
    Location:334425
    Ig; Immunoglobulin domain

RNA

  1. XR_004942438.1 RNA Sequence

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