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Ighm immunoglobulin heavy constant mu [ Mus musculus (house mouse) ]

Gene ID: 16019, updated on 28-Jan-2025

Summary

Official Symbol
Ighmprovided by MGI
Official Full Name
immunoglobulin heavy constant muprovided by MGI
Primary source
MGI:MGI:96448
See related
Ensembl:ENSMUSG00000076617 IMGT/GENE-DB:IGHM; AllianceGenome:MGI:96448
Gene type
other
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Igm; muH; Igh6; Igh-6; Igh-M
Summary
Enables several functions, including antigen binding activity; identical protein binding activity; and immunoglobulin receptor binding activity. Involved in pre-B cell allelic exclusion. Acts upstream of or within several processes, including early endosome to late endosome transport; immunoglobulin mediated immune response; and positive regulation of B cell proliferation. Located in external side of plasma membrane; extracellular space; and perinuclear region of cytoplasm. Part of B cell receptor complex and immunoglobulin complex, circulating. Is active in cytoplasm. Is expressed in several structures, including brain; hemolymphoid system; intestine; and liver. Used to study non-Hodgkin lymphoma and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in agammaglobulinemia 1. Orthologous to human IGHM (immunoglobulin heavy constant mu). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See Ighm in Genome Data Viewer
Location:
12 F1; 12 62.1 cM
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (113382446..113386350, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (113418826..113422730, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr12:114656588-114656889 Neighboring gene STARR-positive B cell enhancer ABC_E744 Neighboring gene STARR-positive B cell enhancer ABC_E3069 Neighboring gene immunoglobulin heavy chain complex Neighboring gene transducin-like enhancer of split 6 pseudogene Neighboring gene transducin-like enhancer of split 6 pseudogene Neighboring gene immunoglobulin heavy joining 4 Neighboring gene immunoglobulin heavy joining 3 Neighboring gene immunoglobulin heavy constant delta

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (9) 
  • Targeted (16)  1 citation

Interactions

General gene information

Other Names

  • Ig mu
  • immunoglobulin heavy chain 6 (heavy chain of IgM)
  • mu-immunoglobulin

Clone Names

  • MGC107036, MGC107507

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables antigen binding  
enables antigen binding PubMed 
enables identical protein binding PubMed 
enables immunoglobulin receptor binding PubMed 
contributes_to immunoglobulin receptor binding  
contributes_to peptidoglycan binding  
contributes_to phosphatidylcholine binding  
enables protein binding PubMed 
contributes_to single-stranded DNA binding  
enables transmembrane signaling receptor activity PubMed 
Items 1 - 25 of 26
Process Evidence Code Pubs
acts_upstream_of B cell activation PubMed 
acts_upstream_of_or_within B cell affinity maturation PubMed 
acts_upstream_of B cell proliferation PubMed 
acts_upstream_of_or_within B cell receptor signaling pathway PubMed 
acts_upstream_of MAPK cascade PubMed 
involved_in adaptive immune response  
involved_in antibacterial humoral response  
involved_in antibacterial humoral response  
acts_upstream_of_or_within antigen processing and presentation  
involved_in complement activation, classical pathway  
acts_upstream_of_or_within defense response to Gram-negative bacterium  
involved_in defense response to Gram-negative bacterium  
acts_upstream_of_or_within early endosome to late endosome transport  
acts_upstream_of_or_within humoral immune response mediated by circulating immunoglobulin PubMed 
acts_upstream_of_or_within immunoglobulin mediated immune response PubMed 
involved_in innate immune response  
acts_upstream_of peptidyl-tyrosine phosphorylation PubMed 
acts_upstream_of_or_within positive regulation of B cell activation PubMed 
acts_upstream_of_or_within positive regulation of B cell proliferation PubMed 
acts_upstream_of_or_within positive regulation of MAPK cascade PubMed 
acts_upstream_of_or_within positive regulation of endocytosis  
acts_upstream_of_or_within positive regulation of immune response PubMed 
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation PubMed 
involved_in pre-B cell allelic exclusion PubMed 
acts_upstream_of_or_within regulation of cell morphogenesis PubMed 
acts_upstream_of_or_within regulation of immunoglobulin production PubMed 
Items 1 - 25 of 26
Component Evidence Code Pubs
part_of B cell receptor complex PubMed 
part_of IgM B cell receptor complex  
part_of IgM B cell receptor complex  
located_in cell surface PubMed 
located_in cell surface  
is_active_in cytoplasm PubMed 
located_in external side of plasma membrane PubMed 
located_in extracellular space PubMed 
located_in extracellular space  
part_of hexameric IgM immunoglobulin complex  
part_of immunoglobulin complex, circulating  
part_of immunoglobulin complex, circulating PubMed 
located_in membrane PubMed 
part_of pentameric IgM immunoglobulin complex  
part_of pentameric IgM immunoglobulin complex  
located_in perinuclear region of cytoplasm PubMed 
located_in plasma membrane  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_005838.1 

    Range
    171230..175134 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    113382446..113386350 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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