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    DTX3L deltex E3 ubiquitin ligase 3L [ Homo sapiens (human) ]

    Gene ID: 151636, updated on 4-Jan-2025

    Summary

    Official Symbol
    DTX3Lprovided by HGNC
    Official Full Name
    deltex E3 ubiquitin ligase 3Lprovided by HGNC
    Primary source
    HGNC:HGNC:30323
    See related
    Ensembl:ENSG00000163840 MIM:613143; AllianceGenome:HGNC:30323
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BBAP; RNF143
    Summary
    Enables several functions, including STAT family protein binding activity; histone H4K91 ubiquitin ligase activity; and protein ADP-ribosyltransferase-substrate adaptor activity. Involved in several processes, including positive regulation of protein localization; protein ubiquitination; and regulation of macromolecule metabolic process. Located in several cellular components, including early endosome; lysosome; and nucleoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in appendix (RPKM 14.2), spleen (RPKM 13.2) and 25 other tissues See more
    Orthologs
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    Genomic context

    See DTX3L in Genome Data Viewer
    Location:
    3q21.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (122564338..122575203)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (125283584..125294443)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (122283185..122294050)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984000 Neighboring gene uncharacterized LOC105374071 Neighboring gene Sharpr-MPRA regulatory region 13157 Neighboring gene poly(ADP-ribose) polymerase family member 9 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14642 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20377 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20378 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20379 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14643 Neighboring gene poly(ADP-ribose) polymerase family member 15 Neighboring gene poly(ADP-ribose) polymerase family member 14 pseudogene Neighboring gene uncharacterized LOC124909419 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20380 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:122353940-122355139 Neighboring gene eukaryotic translation initiation factor 4B pseudogene 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A mega-analysis of genome-wide association studies for major depressive disorder.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling PubMed 
    involved_in DNA repair-dependent chromatin remodeling PubMed 
    involved_in Notch signaling pathway  
    involved_in Notch signaling pathway  
    involved_in defense response to virus  
    involved_in double-strand break repair PubMed 
    involved_in endosome to lysosome transport PubMed 
    involved_in innate immune response  
    involved_in negative regulation of ubiquitin-protein transferase activity PubMed 
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of chromatin binding PubMed 
    involved_in positive regulation of defense response to virus by host PubMed 
    involved_in positive regulation of protein binding PubMed 
    involved_in positive regulation of protein localization to early endosome PubMed 
    involved_in positive regulation of protein localization to nucleus PubMed 
    involved_in positive regulation of receptor catabolic process PubMed 
    involved_in protein K48-linked ubiquitination PubMed 
    involved_in protein autoubiquitination PubMed 
    involved_in protein transport  
    involved_in protein ubiquitination  
    involved_in ubiquitin-dependent protein catabolic process PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    located_in cytosol  
    located_in cytosol  
    colocalizes_with early endosome PubMed 
    located_in early endosome membrane  
    located_in lysosomal membrane  
    located_in lysosome PubMed 
    is_active_in nucleoplasm  
    located_in nucleoplasm  
    colocalizes_with nucleus PubMed 
    located_in nucleus PubMed 
    part_of protein-containing complex PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase DTX3L
    Names
    B-lymphoma- and BAL-associated protein
    RING-type E3 ubiquitin transferase DTX3L
    deltex 3 like, E3 ubiquitin ligase
    deltex 3-like
    rhysin-2
    rhysin2
    NP_612144.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138287.3NP_612144.1  E3 ubiquitin-protein ligase DTX3L

      See identical proteins and their annotated locations for NP_612144.1

      Status: VALIDATED

      Source sequence(s)
      AC092908
      Consensus CDS
      CCDS3015.1
      UniProtKB/Swiss-Prot
      B3KWH6, Q53ZZ3, Q5MJP7, Q8TDB6
      Related
      ENSP00000296161.4, ENST00000296161.9
      Conserved Domains (3) summary
      cd09633
      Location:608738
      Deltex_C; Domain found at the C-terminus of deltex-like
      cd12300
      Location:886
      RRM1_PAR14; RNA recognition motif 1 in vertebrate poly [ADP-ribose] polymerase 14 (PARP-14)
      cd16712
      Location:560600
      RING-HC_DTX3L; RING finger, HC subclass, found in protein Deltex-3-like (DTX3L) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      122564338..122575203
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      125283584..125294443
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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