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Lpar1 lysophosphatidic acid receptor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116744, updated on 4-Jan-2025

Summary

Official Symbol
Lpar1provided by RGD
Official Full Name
lysophosphatidic acid receptor 1provided by RGD
Primary source
RGD:620563
See related
EnsemblRapid:ENSRNOG00000013656 AllianceGenome:RGD:620563
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Edg2
Summary
Enables G-protein alpha-subunit binding activity and phospholipid binding activity. Involved in several processes, including cellular response to 1-oleoyl-sn-glycerol 3-phosphate; nervous system development; and regulation of vesicle-mediated transport. Located in dendritic shaft; dendritic spine; and neuronal cell body. Is active in GABA-ergic synapse; glutamatergic synapse; and synaptic membrane. Used to study hepatocellular carcinoma and transient cerebral ischemia. Orthologous to human LPAR1 (lysophosphatidic acid receptor 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 71.1), Uterus (RPKM 44.2) and 8 other tissues See more
Orthologs
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Genomic context

See Lpar1 in Genome Data Viewer
Location:
5q24
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (78024139..78147071, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (73229047..73347874, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (75557038..75678067, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102546532 Neighboring gene sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 Neighboring gene RIKEN cDNA 4930522L14 gene like Neighboring gene muscle associated receptor tyrosine kinase Neighboring gene uncharacterized LOC120103153 Neighboring gene brain expressed, X-linked 1, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Clone Names

  • MGC105279

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity PubMed 
enables G-protein alpha-subunit binding PubMed 
enables PDZ domain binding  
enables lysophosphatidic acid binding  
enables lysophosphatidic acid receptor activity  
enables lysophosphatidic acid receptor activity  
enables lysophosphatidic acid receptor activity  
enables phospholipid binding PubMed 
Items 1 - 25 of 47
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway PubMed 
acts_upstream_of_or_within G protein-coupled receptor signaling pathway  
involved_in G protein-coupled receptor signaling pathway  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  
acts_upstream_of_or_within bleb assembly  
involved_in cell chemotaxis  
involved_in cellular response to 1-oleoyl-sn-glycerol 3-phosphate PubMed 
involved_in cellular response to oxygen levels PubMed 
involved_in cerebellum development PubMed 
involved_in corpus callosum development PubMed 
involved_in myelination PubMed 
involved_in negative regulation of cAMP/PKA signal transduction PubMed 
involved_in negative regulation of cilium assembly  
involved_in negative regulation of cilium assembly  
involved_in negative regulation of neuron projection development PubMed 
involved_in negative regulation of neuron projection development  
involved_in negative regulation of neuron projection development  
involved_in neurogenesis  
involved_in neurogenesis PubMed 
involved_in oligodendrocyte development PubMed 
involved_in optic nerve development PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway  
acts_upstream_of_or_within positive regulation of MAPK cascade  
involved_in positive regulation of MAPK cascade  
involved_in positive regulation of MAPK cascade  
acts_upstream_of_or_within positive regulation of Rho protein signal transduction  
involved_in positive regulation of Rho protein signal transduction  
involved_in positive regulation of Rho protein signal transduction  
involved_in positive regulation of apoptotic process PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction  
involved_in positive regulation of dendritic spine development PubMed 
involved_in positive regulation of smooth muscle cell chemotaxis PubMed 
involved_in positive regulation of stress fiber assembly  
involved_in positive regulation of stress fiber assembly  
involved_in regulation of cell shape  
involved_in regulation of cell shape  
involved_in regulation of metabolic process  
involved_in regulation of postsynaptic neurotransmitter receptor internalization PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor internalization PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor internalization PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor internalization PubMed 
involved_in regulation of synaptic vesicle cycle PubMed 
involved_in regulation of synaptic vesicle cycle PubMed 
involved_in regulation of synaptic vesicle cycle PubMed 
involved_in regulation of synaptic vesicle cycle PubMed 
Items 1 - 25 of 47
Component Evidence Code Pubs
is_active_in GABA-ergic synapse PubMed 
is_active_in GABA-ergic synapse PubMed 
is_active_in GABA-ergic synapse PubMed 
located_in cell surface  
located_in cell surface  
is_active_in cytoplasm  
located_in dendritic shaft PubMed 
located_in dendritic spine PubMed 
located_in endocytic vesicle  
located_in endosome  
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
located_in neuronal cell body PubMed 
is_active_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane  
is_active_in postsynaptic membrane PubMed 
is_active_in presynaptic membrane PubMed 

General protein information

Preferred Names
lysophosphatidic acid receptor 1
Names
LPA receptor 1
LPA-1
endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2
lysophosphatidic acid receptor Edg-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053936.4NP_446388.1  lysophosphatidic acid receptor 1

    See identical proteins and their annotated locations for NP_446388.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P61794, Q5FWS2
    UniProtKB/TrEMBL
    A6KDV2
    Related
    ENSRNOP00000043652.2, ENSRNOT00000044348.4
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    78024139..78147071 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287075.1XP_063143145.1  lysophosphatidic acid receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    P61794, Q5FWS2
    UniProtKB/TrEMBL
    A6KDV2
  2. XM_006238195.5XP_006238257.1  lysophosphatidic acid receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006238257.1

    UniProtKB/Swiss-Prot
    P61794, Q5FWS2
    UniProtKB/TrEMBL
    A6KDV2
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  3. XM_017593125.3XP_017448614.1  lysophosphatidic acid receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    P61794, Q5FWS2
    UniProtKB/TrEMBL
    A6KDV2
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  4. XM_006238201.5XP_006238263.1  lysophosphatidic acid receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006238263.1

    UniProtKB/Swiss-Prot
    P61794, Q5FWS2
    UniProtKB/TrEMBL
    A6KDV2
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  5. XM_006238197.5XP_006238259.1  lysophosphatidic acid receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006238259.1

    UniProtKB/Swiss-Prot
    P61794, Q5FWS2
    UniProtKB/TrEMBL
    A6KDV2
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  6. XM_063287076.1XP_063143146.1  lysophosphatidic acid receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    P61794, Q5FWS2
    UniProtKB/TrEMBL
    A6KDV2
  7. XM_063287077.1XP_063143147.1  lysophosphatidic acid receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    P61794, Q5FWS2
    UniProtKB/TrEMBL
    A6KDV2
  8. XM_017593127.3XP_017448616.1  lysophosphatidic acid receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    P61794, Q5FWS2
    UniProtKB/TrEMBL
    A6KDV2
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  9. XM_063287078.1XP_063143148.1  lysophosphatidic acid receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    P61794, Q5FWS2
    UniProtKB/TrEMBL
    A6KDV2
  10. XM_006238200.5XP_006238262.1  lysophosphatidic acid receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006238262.1

    UniProtKB/Swiss-Prot
    P61794, Q5FWS2
    UniProtKB/TrEMBL
    A6KDV2
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  11. XM_017593130.3XP_017448619.1  lysophosphatidic acid receptor 1 isoform X2

    Conserved Domains (1) summary
    cd15344
    Location:32304
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
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