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Gars1 glycyl-tRNA synthetase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 297113, updated on 4-Jan-2025

Summary

Official Symbol
Gars1provided by RGD
Official Full Name
glycyl-tRNA synthetase 1provided by RGD
Primary source
RGD:1307856
See related
EnsemblRapid:ENSRNOG00000011052 AllianceGenome:RGD:1307856
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
GlyRS; RGD1559871
Summary
Predicted to enable several functions, including bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity; glycine-tRNA ligase activity; and identical protein binding activity. Predicted to be involved in diadenosine tetraphosphate biosynthetic process and mitochondrial glycyl-tRNA aminoacylation. Predicted to act upstream of or within glycyl-tRNA aminoacylation. Predicted to be located in several cellular components, including axon; extracellular exosome; and secretory granule. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2D and autosomal dominant distal hereditary motor neuronopathy 5. Orthologous to human GARS1 (glycyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 202.2), Kidney (RPKM 199.3) and 9 other tissues See more
Orthologs
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Genomic context

See Gars1 in Genome Data Viewer
Location:
4q24
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (85484939..85542876)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (84171596..84212609)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (85235122..85276085)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486772 Neighboring gene 60S ribosomal protein L12-like Neighboring gene corticotropin releasing hormone receptor 2 Neighboring gene uncharacterized LOC134486773

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding  
enables ATP:ATP adenylyltransferase activity  
enables bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity  
enables bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity  
enables bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity  
enables glycine-tRNA ligase activity  
enables glycine-tRNA ligase activity  
enables glycine-tRNA ligase activity  
enables glycine-tRNA ligase activity  
enables identical protein binding  
enables identical protein binding  
enables protein dimerization activity  
enables protein dimerization activity  
enables protein dimerization activity  
enables transferase activity  
Component Evidence Code Pubs
located_in axon  
located_in axon  
located_in axon  
is_active_in cytoplasm  
located_in cytosol  
located_in cytosol  
located_in extracellular exosome  
located_in extracellular exosome  
located_in extracellular exosome  
is_active_in mitochondrion  
located_in mitochondrion PubMed 
located_in secretory granule  
located_in secretory granule  

General protein information

Preferred Names
glycine--tRNA ligase
Names
AP-4-A synthetase
ap4A synthetase
diadenosine tetraphosphate synthetase
NP_001258068.1
XP_063141841.1
XP_063141842.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271139.2NP_001258068.1  glycine--tRNA ligase

    See identical proteins and their annotated locations for NP_001258068.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    G3V7G8, Q5I0G4
    UniProtKB/TrEMBL
    A0A8L2Q7W8
    Related
    ENSRNOP00000014780.6, ENSRNOT00000014780.8
    Conserved Domains (1) summary
    PLN02734
    Location:45713
    PLN02734; glycyl-tRNA synthetase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    85484939..85542876
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063285772.1XP_063141842.1  glycine--tRNA ligase isoform X2

    Related
    ENSRNOP00000111813.1, ENSRNOT00000127639.1
  2. XM_063285771.1XP_063141841.1  glycine--tRNA ligase isoform X1

    UniProtKB/TrEMBL
    A0A8L2Q7W8
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