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Dmbt1 deleted in malignant brain tumors 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 170568, updated on 4-Jan-2025

Summary

Symbol
Dmbt1provided by RGD
Full Name
deleted in malignant brain tumors 1provided by RGD
Primary source
RGD:61984
See related
EnsemblRapid:ENSRNOG00000090509 AllianceGenome:RGD:61984
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Crpd; Dbmt1
Summary
Predicted to enable several functions, including heparan sulfate binding activity; lipopolysaccharide binding activity; and lipoteichoic acid binding activity. Involved in several processes, including response to biphenyl; response to estrogen; and tissue regeneration. Located in collagen-containing extracellular matrix. Biomarker of pheochromocytoma. Human ortholog(s) of this gene implicated in glioblastoma. Orthologous to human DMBT1 (deleted in malignant brain tumors 1). [provided by Alliance of Genome Resources, Jan 2025]
Annotation information
Annotation category: partial on reference assembly
Expression
Biased expression in Uterus (RPKM 309.3), Spleen (RPKM 127.7) and 8 other tissues See more
Orthologs
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Genomic context

See Dmbt1 in Genome Data Viewer
Location:
1q41
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (195047702..195126704)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (185617469..185696476)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (201620642..201689905) , (203149414..203228705)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing A1 Neighboring gene uncharacterized LOC134485181 Neighboring gene HtrA serine peptidase 1 Neighboring gene similar to human chromosome 10 open reading frame 120 Neighboring gene deleted in malignant brain tumors 1 like 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding  
enables heparan sulfate binding  
enables lipopolysaccharide binding  
enables lipoteichoic acid binding  
enables pattern recognition receptor activity  
enables scavenger receptor activity  
enables zymogen binding  
enables zymogen binding  
Process Evidence Code Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide  
acts_upstream_of_or_within blastocyst development  
involved_in cell differentiation  
involved_in cell differentiation PubMed 
acts_upstream_of columnar/cuboidal epithelial cell differentiation  
involved_in defense response  
involved_in defense response to Gram-negative bacterium  
involved_in defense response to Gram-negative bacterium  
involved_in defense response to Gram-positive bacterium  
involved_in defense response to Gram-positive bacterium  
acts_upstream_of_or_within inner cell mass cell proliferation  
acts_upstream_of_or_within positive regulation of epithelial cell differentiation  
involved_in protein transport  
involved_in receptor-mediated endocytosis  
acts_upstream_of_or_within response to bacterium  
involved_in response to biphenyl PubMed 
involved_in response to estrogen PubMed 
involved_in tissue regeneration PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix PubMed 
located_in cytoplasm  
is_active_in extracellular matrix  
located_in extracellular matrix  
located_in extracellular matrix  
located_in extracellular region  
located_in extracellular space  
located_in membrane  
located_in phagocytic vesicle membrane  
located_in transport vesicle membrane  
located_in zymogen granule membrane  
located_in zymogen granule membrane  

General protein information

Preferred Names
scavenger receptor cysteine-rich domain-containing protein DMBT1
Names
crp-ductin
deleted in malignant brain tumors 1 protein
deleted in malignant brain tumors 1 protein-like
ebnerin
hensin
pancrin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429894.1 → NP_001416823.1  scavenger receptor cysteine-rich domain-containing protein DMBT1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    D3ZZV0

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    195047702..195126704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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