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Slc9a3 solute carrier family 9 member A3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24784, updated on 4-Jan-2025

Summary

Official Symbol
Slc9a3provided by RGD
Official Full Name
solute carrier family 9 member A3provided by RGD
Primary source
RGD:3720
See related
EnsemblRapid:ENSRNOG00000015159 AllianceGenome:RGD:3720
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nhe3
Summary
Enables sodium:proton antiporter activity. Involved in several processes, including regulation of pH; response to glucocorticoid; and sodium ion transport. Located in apical plasma membrane; brush border membrane; and recycling endosome membrane. Used to study hypertension. Biomarker of obesity and renovascular hypertension. Human ortholog(s) of this gene implicated in congenital secretory sodium diarrhea 8. Orthologous to human SLC9A3 (solute carrier family 9 member A3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 198.2) and Brain (RPKM 11.8) See more
Orthologs
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Genomic context

See Slc9a3 in Genome Data Viewer
Location:
1p11
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (30953215..30996209, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (29124633..29167912, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (31731652..31777144, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene aryl-hydrocarbon receptor repressor Neighboring gene uncharacterized LOC108349507 Neighboring gene exocyst complex component 3 Neighboring gene centrosomal protein 72 Neighboring gene tubulin polymerization promoting protein

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables PDZ domain binding  
enables PDZ domain binding  
enables identical protein binding  
enables identical protein binding  
enables identical protein binding  
enables phosphatidylinositol binding  
enables phosphatidylinositol binding  
enables phosphatidylinositol binding  
enables potassium:proton antiporter activity  
enables protein binding PubMed 
enables sodium:proton antiporter activity  
enables sodium:proton antiporter activity PubMed 
enables sodium:proton antiporter activity  
enables sodium:proton antiporter activity  
Process Evidence Code Pubs
involved_in circadian rhythm PubMed 
involved_in potassium ion transmembrane transport  
involved_in proton transmembrane transport  
involved_in receptor-mediated endocytosis PubMed 
involved_in regulation of intracellular pH  
involved_in regulation of intracellular pH  
involved_in regulation of intracellular pH  
involved_in regulation of pH PubMed 
involved_in regulation of pH  
acts_upstream_of_or_within regulation of pH  
involved_in regulation of sodium ion transport PubMed 
involved_in response to glucocorticoid PubMed 
involved_in sodium ion import across plasma membrane  
involved_in sodium ion import across plasma membrane  
involved_in sodium ion import across plasma membrane  
involved_in sodium ion import across plasma membrane  
involved_in sodium ion transmembrane transport  
involved_in sodium ion transport PubMed 
acts_upstream_of_or_within sodium ion transport  
Component Evidence Code Pubs
is_active_in apical plasma membrane  
located_in apical plasma membrane PubMed 
located_in apical plasma membrane  
located_in apical plasma membrane  
located_in brush border PubMed 
is_active_in brush border membrane  
located_in brush border membrane PubMed 
located_in brush border membrane  
located_in early endosome  
located_in early endosome membrane  
located_in extracellular exosome  
located_in extracellular exosome  
is_active_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane  
located_in recycling endosome membrane PubMed 
located_in recycling endosome membrane  
located_in recycling endosome membrane  
located_in vesicle  

General protein information

Preferred Names
sodium/hydrogen exchanger 3
Names
NHE-3
Na(+)/H(+) exchanger 3
Solute carrier family 9 (sodium/hydrogen exchanger 3), antiporter 3, Na+/H+ (amiloride insensitive)
plasma membrane ion transport protein
solute carrier family 9 (sodium/hydrogen exchanger), member 3
solute carrier family 9 member 3
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001414040.1NP_001400969.1  sodium/hydrogen exchanger 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1 and 2 encode the same protein.
    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    P26433
    UniProtKB/TrEMBL
    A6JUV3, G3V7Y7
    Related
    ENSRNOP00000083053.2, ENSRNOT00000094251.2
  2. NM_012654.3NP_036786.2  sodium/hydrogen exchanger 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1 and 2 encode the same protein.
    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    P26433
    UniProtKB/TrEMBL
    A6JUV3, G3V7Y7
    Related
    ENSRNOP00000020711.2, ENSRNOT00000020711.5
    Conserved Domains (1) summary
    TIGR00840
    Location:45644
    b_cpa1; sodium/hydrogen exchanger 3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    30953215..30996209 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039100846.2XP_038956774.1  sodium/hydrogen exchanger 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZZ59
    Conserved Domains (1) summary
    TIGR00840
    Location:45644
    b_cpa1; sodium/hydrogen exchanger 3
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