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Igf2bp1 insulin-like growth factor 2 mRNA binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 140486, updated on 4-Jan-2025

Summary

Official Symbol
Igf2bp1provided by MGI
Official Full Name
insulin-like growth factor 2 mRNA binding protein 1provided by MGI
Primary source
MGI:MGI:1890357
See related
Ensembl:ENSMUSG00000013415 AllianceGenome:MGI:1890357
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IMP1; Zbp1; Crdbp; ZBP-1; CRD-BP; Neilsen; D11Moh45; mir-3063; D11Moh40e; D030026A21Rik
Summary
Enables mRNA 3'-UTR binding activity. Involved in positive regulation of cytoplasmic translation. Acts upstream of or within neuronal stem cell population maintenance and pallium cell proliferation in forebrain. Predicted to be located in several cellular components, including cytoplasmic ribonucleoprotein granule; dendritic spine; and neuronal cell body. Predicted to be part of CRD-mediated mRNA stability complex and ribonucleoprotein complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including central nervous system; eye; gonad; intestine; and limb. Orthologous to human IGF2BP1 (insulin like growth factor 2 mRNA binding protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in CNS E11.5 (RPKM 17.9), placenta adult (RPKM 10.3) and 7 other tissues See more
Orthologs
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Genomic context

See Igf2bp1 in Genome Data Viewer
Location:
11 D; 11 59.08 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (95847989..95896770, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (95957163..96005944, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene beta-1,4-N-acetyl-galactosaminyl transferase 2 Neighboring gene predicted gene, 24725 Neighboring gene STARR-seq mESC enhancer starr_30524 Neighboring gene microRNA 3063 Neighboring gene STARR-seq mESC enhancer starr_30526 Neighboring gene STARR-seq mESC enhancer starr_30529 Neighboring gene STARR-seq mESC enhancer starr_30530 Neighboring gene predicted gene, 24949 Neighboring gene gastric inhibitory polypeptide

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N6-methyladenosine-containing RNA reader activity  
enables N6-methyladenosine-containing RNA reader activity  
enables mRNA 3'-UTR binding  
enables mRNA 3'-UTR binding PubMed 
enables mRNA 3'-UTR binding  
enables mRNA 5'-UTR binding  
enables mRNA 5'-UTR binding  
enables mRNA binding  
enables mRNA binding  
enables translation regulator activity  
enables translation regulator activity  
Process Evidence Code Pubs
involved_in CRD-mediated mRNA stabilization  
involved_in CRD-mediated mRNA stabilization  
involved_in CRD-mediated mRNA stabilization  
involved_in RNA localization  
involved_in dendrite arborization  
involved_in dendrite arborization  
involved_in mRNA transport  
involved_in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  
involved_in negative regulation of translation  
involved_in negative regulation of translation  
involved_in nervous system development  
acts_upstream_of_or_within neuronal stem cell population maintenance PubMed 
acts_upstream_of_or_within pallium cell proliferation in forebrain PubMed 
involved_in positive regulation of cytoplasmic translation PubMed 
involved_in positive regulation of cytoplasmic translation  
involved_in regulation of mRNA stability involved in response to stress  
involved_in regulation of mRNA stability involved in response to stress  
Items 1 - 20 of 25
Component Evidence Code Pubs
part_of CRD-mediated mRNA stability complex  
part_of CRD-mediated mRNA stability complex  
located_in P-body  
located_in P-body  
located_in axon  
is_active_in cytoplasm  
located_in cytoplasm  
located_in cytoplasmic stress granule  
located_in cytoplasmic stress granule  
is_active_in cytosol  
located_in cytosol  
located_in dendrite  
located_in dendritic spine  
located_in dendritic spine  
located_in filopodium  
located_in growth cone  
located_in lamellipodium  
located_in neuronal cell body  
located_in neuronal cell body  
located_in nucleoplasm  
located_in nucleoplasm  
is_active_in nucleus  
located_in perinuclear region of cytoplasm  
part_of ribonucleoprotein complex  
part_of ribonucleoprotein complex  
Items 1 - 20 of 25

General protein information

Preferred Names
insulin-like growth factor 2 mRNA-binding protein 1
Names
IGF-II mRNA-binding protein 1
IGF2 mRNA-binding protein 1
VICKZ family member 1
coding region determinant binding protein
insulin-like growth factor 2 mRNA binding protein 1 dN CRDBP-2
insulin-like growth factor 2 mRNA binding protein 1 deltaN CRDBP
insulin-like growth factor 2, binding protein 1
zipcode binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401454.1NP_001388383.1  insulin-like growth factor 2 mRNA-binding protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL603682, AL606704
  2. NM_001401455.1NP_001388384.1  insulin-like growth factor 2 mRNA-binding protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL603682, AL606704
  3. NM_001401456.1NP_001388385.1  insulin-like growth factor 2 mRNA-binding protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL603682, AL606704
    UniProtKB/TrEMBL
    A0A0H3XWX3
  4. NM_001401457.1NP_001388386.1  insulin-like growth factor 2 mRNA-binding protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL603682, AL606704
    UniProtKB/TrEMBL
    A0A0H3XWX3
  5. NM_009951.4NP_034081.1  insulin-like growth factor 2 mRNA-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_034081.1

    Status: VALIDATED

    Source sequence(s)
    AL603682, AL606704
    Consensus CDS
    CCDS25286.1
    UniProtKB/Swiss-Prot
    O88477, Q80US9, Q8BRH1
    Related
    ENSMUSP00000013559.3, ENSMUST00000013559.3
    Conserved Domains (4) summary
    cd00105
    Location:279344
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd12625
    Location:177
    RRM1_IGF2BP1; RNA recognition motif 1 in vertebrate insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)
    cd12628
    Location:81156
    RRM2_IGF2BP1; RNA recognition motif 2 in vertebrate insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)
    pfam00013
    Location:408471
    KH_1; KH domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    95847989..95896770 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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