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Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 [ Mus musculus (house mouse) ]

Gene ID: 13122, updated on 13-Jan-2025

Summary

Official Symbol
Cyp7a1provided by MGI
Official Full Name
cytochrome P450, family 7, subfamily a, polypeptide 1provided by MGI
Primary source
MGI:MGI:106091
See related
Ensembl:ENSMUSG00000028240 AllianceGenome:MGI:106091
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CYPVII; CYPVIIc
Summary
Enables cholesterol 7-alpha-monooxygenase activity. Acts upstream of or within cholesterol catabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in liver. Orthologous to human CYP7A1 (cytochrome P450 family 7 subfamily A member 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in liver E18 (RPKM 9.1) and liver adult (RPKM 7.9) See more
Orthologs
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Genomic context

See Cyp7a1 in Genome Data Viewer
Location:
4 A1; 4 2.91 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (6265612..6275632, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (6265612..6275632, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene Ras suppressor protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_09476 Neighboring gene STARR-positive B cell enhancer ABC_E3480 Neighboring gene UBX domain protein 2B Neighboring gene Cyp7a1 promoter Neighboring gene STARR-seq mESC enhancer starr_09478 Neighboring gene STARR-seq mESC enhancer starr_09479 Neighboring gene RIKEN cDNA 4930430E12 gene Neighboring gene syndecan binding protein

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (3)  1 citation

Pathways from PubChem

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 24-hydroxycholesterol 7alpha-hydroxylase activity  
enables cholesterol 7-alpha-monooxygenase activity  
enables cholesterol 7-alpha-monooxygenase activity PubMed 
enables cholesterol 7-alpha-monooxygenase activity  
enables cholesterol 7-alpha-monooxygenase activity  
enables heme binding  
enables iron ion binding  
Items 1 - 25 of 26
Process Evidence Code Pubs
involved_in bile acid and bile salt transport  
involved_in bile acid biosynthetic process  
involved_in bile acid biosynthetic process  
involved_in bile acid biosynthetic process  
involved_in bile acid biosynthetic process  
involved_in cellular response to cholesterol  
involved_in cellular response to cholesterol  
involved_in cellular response to glucose stimulus  
involved_in cellular response to glucose stimulus  
acts_upstream_of_or_within cholesterol catabolic process PubMed 
involved_in cholesterol catabolic process  
involved_in cholesterol catabolic process  
involved_in cholesterol catabolic process  
involved_in cholesterol homeostasis  
involved_in cholesterol homeostasis  
involved_in cholesterol homeostasis  
involved_in negative regulation of collagen biosynthetic process  
involved_in negative regulation of collagen biosynthetic process  
involved_in negative regulation of fatty acid biosynthetic process  
involved_in negative regulation of fatty acid biosynthetic process  
involved_in positive regulation of bile acid biosynthetic process PubMed 
involved_in positive regulation of cholesterol biosynthetic process  
involved_in positive regulation of cholesterol biosynthetic process  
involved_in regulation of bile acid biosynthetic process  
involved_in regulation of bile acid biosynthetic process  
involved_in response to ethanol  
Items 1 - 25 of 26
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane  
is_active_in intracellular membrane-bounded organelle  
located_in intracellular membrane-bounded organelle  
located_in intracellular membrane-bounded organelle  

General protein information

Preferred Names
cytochrome P450 7A1
Names
24-hydroxycholesterol 7-alpha-hydroxylase
cholesterol 7-alpha-hydroxylase
cholesterol 7-alpha-monooxygenase
cytochrome P450, 7a1
NP_031850.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007824.3NP_031850.2  cytochrome P450 7A1

    See identical proteins and their annotated locations for NP_031850.2

    Status: VALIDATED

    Source sequence(s)
    AK050210, AK050260
    Consensus CDS
    CCDS17950.1
    UniProtKB/Swiss-Prot
    Q64505, Q8BFR7
    UniProtKB/TrEMBL
    A1L3S6
    Related
    ENSMUSP00000029905.2, ENSMUST00000029905.2
    Conserved Domains (1) summary
    cd20631
    Location:55497
    CYP7A1; cytochrome P450 family 7, subfamily A, polypeptide 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    6265612..6275632 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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